Lorin Charlton
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View article: Activation of stress-activated kinases and inhibition of PI 3-K/PKB and p70S6K mitogenic signaling pathway by photodynamic therapy in murine keratinocytes
Activation of stress-activated kinases and inhibition of PI 3-K/PKB and p70S6K mitogenic signaling pathway by photodynamic therapy in murine keratinocytes Open
Photodynamic therapy (PDT) is a new anti-cancer modality. It involves the use of photosensitizer molecules and a specific wavelength of visible light. The process of PDT generates singlet oxygen and other reactive oxygen intermediates (ROI…
View article: The 70 kDa S6 kinase : enrichment and characterization of sea star homologue, and the role of p70S6K in the transformed keratinocyte cell line Pam212 in response to photodynamic therapy
The 70 kDa S6 kinase : enrichment and characterization of sea star homologue, and the role of p70S6K in the transformed keratinocyte cell line Pam212 in response to photodynamic therapy Open
The 70 kDa ribosomal protein S6 kinase (p70s6k) has been implicated in the control of cell proliferation and the onset of protein synthesis following mitogenic and hormonal stimulation. Due to the importance of this role in signal transduc…
View article: Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: protein kinase C-dependent and phosphatidylinositol-3-kinase-independent pathways
Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: protein kinase C-dependent and phosphatidylinositol-3-kinase-independent pathways Open
Phosphatidylinositol 3-kinase (PI 3-kinase) has been shown previously to be a central enzyme in crystal-induced neutrophil activation. Since activation of the 70 kDa S6 kinase (p70S6K) has been shown to be dependent on PI 3-kinase activati…
View article: Structure-function analysis of casein kinase 2 with synthetic peptides and anti-peptide antibodies.
Structure-function analysis of casein kinase 2 with synthetic peptides and anti-peptide antibodies. Open
Casein kinase 2 (CK2) is a ubiquitous, multifunctional protein-seryl/threonyl kinase that has been implicated in cellular regulation. Synthetic peptides were patterned after three highly conserved regions in CK2: the N terminus (CK2-NT); t…
View article: Purification and characterization of echinoderm casein kinase II. Regulation by protein kinase C
Purification and characterization of echinoderm casein kinase II. Regulation by protein kinase C Open
Casein kinase II (CKII) is one of several protein kinases that become activated before germinal-vesicle breakdown in maturing sea-star oocytes. Echinoderm CKII was purified over 11,000-fold with a recovery of approximately 10% by sequentia…