Lorne J. Gula
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View article: A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome
A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome Open
Importance Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with st…
View article: Efficacy and safety of supraclavicular and pectoralis nerve blocks as primary peri‐procedural analgesia for cardiac electronic device implantation: A pilot study
Efficacy and safety of supraclavicular and pectoralis nerve blocks as primary peri‐procedural analgesia for cardiac electronic device implantation: A pilot study Open
Background Cardiac implantable electronic devices (CIEDs) are routinely implanted using intravenous drugs for sedation. However, some patients are poor candidates for intravenous sedation. Objective We present a case series demonstrating t…
View article: A Sensible Decision
A Sensible Decision Open
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View article: Comparative effectiveness of ventricular tachycardia ablation vs. escalated antiarrhythmic drug therapy by location of myocardial infarction: a sub-study of the VANISH trial
Comparative effectiveness of ventricular tachycardia ablation vs. escalated antiarrhythmic drug therapy by location of myocardial infarction: a sub-study of the VANISH trial Open
Aims Complexity of the ventricular tachycardia (VT) substrate and the size and thickness of infarction area border zones differ based on location of myocardial infarctions (MIs). These differences may translate into heterogeneity in the ef…
View article: Comparative effectiveness of ventricular tachycardia ablation versus escalated antiarrhythmic drug therapy by location of myocardial infarction: A sub-study of the VANISH trial
Comparative effectiveness of ventricular tachycardia ablation versus escalated antiarrhythmic drug therapy by location of myocardial infarction: A sub-study of the VANISH trial Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Fonds de recherché du Québec-Santé (FRQS) [post doctoral award for Dr. Samuel) BACKGROUND Complexity of ventricular tachycardia (VT) substrate…
View article: Evaluating Polygenic Risk Scores in “Lone” Atrial Fibrillation
Evaluating Polygenic Risk Scores in “Lone” Atrial Fibrillation Open
Our study evaluating 2 polygenic scores for AF suggests that the GPS, containing more than 6.7 million SNPs, exhibits an improved discriminatory capacity in lone AF compared with a PRS possessing 1168 SNPs. Our findings suggest that geneti…
View article: Enrichment of loss-of-function and copy number variants in ventricular cardiomyopathy genes in ‘lone’ atrial fibrillation
Enrichment of loss-of-function and copy number variants in ventricular cardiomyopathy genes in ‘lone’ atrial fibrillation Open
Aims Atrial fibrillation (AF) is a complex heritable disease whose genetic underpinnings remain largely unexplained, though recent work has suggested that the arrhythmia may develop secondary to an underlying atrial cardiomyopathy. We soug…
View article: Value of the Signal-Averaged ECG in Supraventricular Tachycardia Diagnosis
Value of the Signal-Averaged ECG in Supraventricular Tachycardia Diagnosis Open
Background: We hypothesized that signal averaged ECG during tachycardia would facilitate P wave recognition and assist in SVT diagnosis. P waves adjacent to the QRS during tachycardia would lengthen the filtered QRS and be recognized by su…
View article: An International Multicenter Evaluation of Type 5 Long QT Syndrome
An International Multicenter Evaluation of Type 5 Long QT Syndrome Open
Background: Insight into type 5 long QT syndrome (LQT5) has been limited to case reports and small family series. Improved understanding of the clinical phenotype and genetic features associated with rare KCNE1 variants implicated in LQT5 …
View article: Cryoballoon or Radiofrequency Ablation for Atrial Fibrillation Assessed by Continuous Monitoring
Cryoballoon or Radiofrequency Ablation for Atrial Fibrillation Assessed by Continuous Monitoring Open
Background: Advanced generation ablation technologies have been developed to achieve more effective pulmonary vein isolation (PVI) and minimize arrhythmia recurrence after atrial fibrillation (AF) ablation. Methods: We randomly assigned 34…
View article: Incremental Value of Implantable Cardiac Device Diagnostic Variables Over Clinical Parameters to Predict Mortality in Patients With Mild to Moderate Heart Failure
Incremental Value of Implantable Cardiac Device Diagnostic Variables Over Clinical Parameters to Predict Mortality in Patients With Mild to Moderate Heart Failure Open
Background Heart failure remains a leading cause of morbidity and mortality. Clinical prediction models provide suboptimal estimates of mortality in this population. We sought to determine the incremental value of implantable device diagno…
View article: Sensitivity and specificity of chest imaging for sarcoidosis screening in patients with cardiac presentations.
Sensitivity and specificity of chest imaging for sarcoidosis screening in patients with cardiac presentations. Open
During the initial diagnostic workup of patients with suspected CS, chest x-ray was suboptimal as a screening test. In contrast CT chest and cardiac/thorax MRI had excellent sensitivity. Chest CT has the highest specificity among imaging m…
View article: Effect of Baseline Antiarrhythmic Drug on Outcomes With Ablation in Ischemic Ventricular Tachycardia
Effect of Baseline Antiarrhythmic Drug on Outcomes With Ablation in Ischemic Ventricular Tachycardia Open
Background The VANISH trial (Ventricular Tachycardia Ablation Versus Escalated Antiarrhythmic Drug Therapy in Ischemic Heart Disease) compared the effectiveness of escalated antiarrhythmic drug therapy to catheter ablation in patients with…
View article: Measuring the Impact of Guideline Concordance
Measuring the Impact of Guideline Concordance Open
a group working with the RAND (Research and Development) corporation began making 13 000 telephone calls to random individuals in 12 American cities to ask people about their health care. 1 The investigators suspected that a proportion of …
View article: Loss-of-Function <i>KCNE2</i> Variants
Loss-of-Function <i>KCNE2</i> Variants Open
Background— Insight into type 6 long-QT syndrome (LQT6), stemming from mutations in the KCNE2 -encoded voltage-gated channel β-subunit, is limited. We sought to further characterize its clinical phenotype. Methods and Results— Individuals …
View article: Effect of Aggressive Blood Pressure Control on the Recurrence of Atrial Fibrillation After Catheter Ablation
Effect of Aggressive Blood Pressure Control on the Recurrence of Atrial Fibrillation After Catheter Ablation Open
Background: Radiofrequency catheter ablation for atrial fibrillation has become an important therapy for AF; however, recurrence rates remain high. We proposed to determine whether aggressive blood pressure (BP) lowering prevents recurrent…
View article: Indigenous Student Matriculation into Medical School: Policy and Progress
Indigenous Student Matriculation into Medical School: Policy and Progress Open
Access to health care remains suboptimal for Indigenous people in Canada. One contributing factor is the longstanding undersupply of Indigenous physicians. Despite awareness of this issue, underrepresentation in medical schools continues. …
View article: Clinical Role of Dominant Frequency Measurements in Atrial Fibrillation Ablation – A Systematic Review
Clinical Role of Dominant Frequency Measurements in Atrial Fibrillation Ablation – A Systematic Review Open
No prior study has systematically comprised information for clinical use of DF. The current literature supports global DF as a useful marker of ablation outcome; however direct intervention targeting DF appears premature with mixed results…
View article: Risk of Ventricular Arrhythmia with Citalopram and Escitalopram: A Population-Based Study
Risk of Ventricular Arrhythmia with Citalopram and Escitalopram: A Population-Based Study Open
Among older adults, initiation of citalopram compared to two referent antidepressants was associated with a small but statistically significant increase in the 90-day risk of a hospital encounter for ventricular arrhythmia.
View article: Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs
Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs Open
In patients with ischemic cardiomyopathy and an ICD who had ventricular tachycardia despite antiarrhythmic drug therapy, there was a significantly lower rate of the composite primary outcome of death, ventricular tachycardia storm, or appr…
View article: A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation Open
Atrial fibrillation (AF), the most common arrhythmia, is a growing epidemic with substantial morbidity and economic burden. Mechanisms underlying vulnerability to AF remain poorly understood, which contributes to the current lack of highly…