Loryn Holokai
YOU?
Author Swipe
View article: Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution
Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution Open
The intestinal epithelium is often a site of pathology, such as in inflammatory bowel disease (IBD), and its maintenance is highly modulated by interactions with the microenvironment. However, a systematic understanding of how the myriad o…
View article: Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for<i>TNF</i>mRNA m6A modification
Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for<i>TNF</i>mRNA m6A modification Open
Macrophages adopt dynamic cell states with distinct effector functions to maintain tissue homeostasis and respond to environmental challenges. During chronic inflammation, macrophage polarization is subverted towards sustained inflammatory…
View article: Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma
Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma Open
Purpose: Pancreatic ductal adenocarcinoma (PDAC) has the lowest five-year survival rate of all cancers in the United States. Programmed death 1 receptor (PD-1)-programmed death ligand 1 (PD-L1) immune checkpoint inhibition has been unsucce…
View article: Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection
Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection Open
Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initia…
View article: Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer
Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer Open
Tumor cells expressing programmed cell death ligand 1 (PD-L1) interact with PD-1 on CD8+ cytotoxic T lymphocytes (CTLs) to inhibit CTL effector function. In gastric cancer, the mechanism regulating PD-L1 is unclear. The Hedgehog (Hh) signa…
View article: An Organoid-Based Preclinical Model of Human Gastric Cancer
An Organoid-Based Preclinical Model of Human Gastric Cancer Open
View article: Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration Open
In vitro studies of gastric wound repair typically involves the use of gastric cancer cell lines in a scratch-wound assay of cellular proliferation and migration. One critical limitation of such assays, however, is their homogenous assortm…