Loubna Khalki
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View article: Assessing ADME gene coverage: An observational study on chloroquine therapy for COVID-19
Assessing ADME gene coverage: An observational study on chloroquine therapy for COVID-19 Open
This observational study aimed to compare various genotyping and enrichment platforms to determine the most comprehensive coverage for genome-wide association studies, specifically targeting new therapeutic approaches against coronaviruses…
View article: Afucosylated IgG Promote Thrombosis in Mouse Injected with SARS-CoV-2 Spike Expressing Megakaryocytes
Afucosylated IgG Promote Thrombosis in Mouse Injected with SARS-CoV-2 Spike Expressing Megakaryocytes Open
Despite the prevalence of fucosylated IgG in plasma, specific IgGs with low core fucosylation sporadically emerge in response to virus infections and blood cell alloantigens. This low fucosylation of IgG is implicated in the pathogenesis o…
View article: Gut microbiota alterations are linked to COVID-19 severity in North African and European populations
Gut microbiota alterations are linked to COVID-19 severity in North African and European populations Open
View article: Megakaryocyte infection by SARS-CoV-2 drives the formation of pathogenic afucosylated IgG antibodies in mice
Megakaryocyte infection by SARS-CoV-2 drives the formation of pathogenic afucosylated IgG antibodies in mice Open
More than 90% of total human plasma immunoglobulin G (IgG) is found in a fucosylated form, but specific IgGs with low core fucosylation (afucosylated IgGs) are found in response to infections with enveloped viruses and to alloantigens on b…
View article: Low α-Thrombin/GPIbα Interaction Is a Potential Contributor to Platelet Hyper-reactivity in COVID-19 Patients
Low α-Thrombin/GPIbα Interaction Is a Potential Contributor to Platelet Hyper-reactivity in COVID-19 Patients Open
Received: 08 November 2022 Accepted after revision: 14 March 2023 Accepted Manuscript online:12 April 2023
View article: Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells
Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells Open
Platelets are hyperactivated in coronavirus disease 2019 (COVID-19). However, the mechanisms promoting platelet activation by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood. This may be due to inherent…
View article: Aspirin use Reduces Platelet Hyperreactivity and Degranulation in COVID-19 Patients
Aspirin use Reduces Platelet Hyperreactivity and Degranulation in COVID-19 Patients Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is spreading throughout the world at an alarming rate.[1] Severe disease is characterized by acute respiratory distre…
View article: An Update of Research Animal Models of Inflammatory Bowel Disease
An Update of Research Animal Models of Inflammatory Bowel Disease Open
Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn’s disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advance…
View article: Oxford-AstraZeneca ChAdOx1 COVID-19 Vaccine Does Not Alter Platelet Aggregation
Oxford-AstraZeneca ChAdOx1 COVID-19 Vaccine Does Not Alter Platelet Aggregation Open
Since the emergence of SARS-CoV-2 in China in December 2019 and the subsequent coronavirus disease 2019 (COVID-19), and as a consequence of the rapid spread worldwide, the World Health Organization (WHO) declared the outbreak a serious pub…
View article: Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19
Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19 Open
Rationale: In addition to the overwhelming lung inflammation that prevails in coronavirus disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coro…
View article: Platelets can contain SARS-CoV-2 RNA and are hyperactivated in COVID-19
Platelets can contain SARS-CoV-2 RNA and are hyperactivated in COVID-19 Open
Rationale In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Plat…
View article: Alteration of glycinergic receptor expression in lumbar spinal motoneurons is involved in the mechanisms underlying spasticity after spinal cord injury
Alteration of glycinergic receptor expression in lumbar spinal motoneurons is involved in the mechanisms underlying spasticity after spinal cord injury Open
View article: Coverage Rate of ADME Genes: Application to CYP2C8, CYP2D6 and CYP3A Genes for Personalized Chloroquine Treatment Against Coronavirus
Coverage Rate of ADME Genes: Application to CYP2C8, CYP2D6 and CYP3A Genes for Personalized Chloroquine Treatment Against Coronavirus Open
Background: The latest studies have shown the effectiveness of Chloroquine against Coronavirus. However, since the tolerance and effectiveness of statistical data must be taken into account before proposing treatment to a patient, these pr…
View article: Antitumoral activity of Ficus carica L. on colorectal cancer cell lines
Antitumoral activity of Ficus carica L. on colorectal cancer cell lines Open
In traditional medicine, Ficus carica (also known as fig) latex is recognized as a remedy with various therapeutic effects. In the present study we investigated the antitumor activity of Ficus carica extracts and latex. We evaluated the ef…
View article: Coverage rate of ADME genes from commercial sequencing arrays
Coverage rate of ADME genes from commercial sequencing arrays Open
Pharmacogenomics offers remarkable potential for the rapid translation of discoveries into changes in clinical practice. In the present work, we are interested in evaluating the ability of commercially available genome-wide association seq…
View article: No Discrete Start/Stop Signals in the Dorsal Striatum of Mice Performing a Learned Action
No Discrete Start/Stop Signals in the Dorsal Striatum of Mice Performing a Learned Action Open
View article: Changes in innervation of lumbar motoneurons and organization of premotor network following training of transected adult rats
Changes in innervation of lumbar motoneurons and organization of premotor network following training of transected adult rats Open