Louis Delhaye
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View article: TurboID proximity interactome mapping reveals NR2E3 association with AP-1 and retinal developmental complexes
TurboID proximity interactome mapping reveals NR2E3 association with AP-1 and retinal developmental complexes Open
The photoreceptor-specific nuclear receptor NR2E3 is a key transcription factor in the retinal transcriptional network, essential in photoreceptor cell fate and maintenance. Various biallelic loss-of-function variants lead to autosomal rec…
View article: Rapid assay optimization by plug-and-play MAPPIT
Rapid assay optimization by plug-and-play MAPPIT Open
Studying protein-protein interactions, which are crucial for all cellular processes in both health and disease, offers valuable insights into underlying mechanisms and reveals promising therapeutic targets. While efforts have been made to …
View article: Virotrap Reveals <i>Salmonella</i> SopB as A Ubiquitinated Cargo for Host ESCRT-0
Virotrap Reveals <i>Salmonella</i> SopB as A Ubiquitinated Cargo for Host ESCRT-0 Open
The pathogenic bacterium Salmonella survives and replicates in host cells within a Salmonella -containing vacuole (SCV). To build this niche, Salmonella uses secreted effectors, such as SopB, a phosphoinositide phosphotransferase that modi…
View article: A co-culture model to study modulators of tumor immune evasion through scalable arrayed CRISPR-interference screens
A co-culture model to study modulators of tumor immune evasion through scalable arrayed CRISPR-interference screens Open
Cancer cells effectively evade immune surveillance, not only through the well-known PD-1/PD-L1 pathway but also via alternative mechanisms that impair patient response to immune checkpoint inhibitors. We present a novel co-culture model th…
View article: MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids
MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids Open
View article: Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics Open
Protein-protein interactions play an important biological role in every aspect of cellular homeostasis and functioning. Proximity labeling mass spectrometry-based proteomics overcomes challenges typically associated with other methods and …
View article: Selective Modulation of the Human Glucocorticoid Receptor Compromises GR Chromatin Occupancy and Recruitment of p300/CBP and the Mediator Complex
Selective Modulation of the Human Glucocorticoid Receptor Compromises GR Chromatin Occupancy and Recruitment of p300/CBP and the Mediator Complex Open
View article: Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics Open
Summary Protein-protein interactions play an important biological role in every aspect of cellular homeostasis and functioning. Proximity labeling mass spectrometry-based proteomics overcomes challenges typically associated with other meth…
View article: MX2 restricts HIV-1 and herpes simplex virus type 1 by forming cytoplasmic biomolecular condensates that mimic nuclear pore complexes
MX2 restricts HIV-1 and herpes simplex virus type 1 by forming cytoplasmic biomolecular condensates that mimic nuclear pore complexes Open
Summary Human myxovirus resistance 2 (MX2) can potently restrict HIV-1 and herpesviruses at a post-entry step by a process that requires MX2 interaction with the capsids of these viruses. The involvement of other host cell factors in this …
View article: Antagonism and selective modulation of the human glucocorticoid receptor both reduce recruitment of p300/CBP and the Mediator complex
Antagonism and selective modulation of the human glucocorticoid receptor both reduce recruitment of p300/CBP and the Mediator complex Open
Exogenous glucocorticoids are frequently used to treat inflammatory disorders and as adjuncts for treatment of solid cancers. However, their use is associated with severe side effects and therapy resistance. Novel glucocorticoid receptor (…
View article: The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA
The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA Open
The PHF6 protein is a presumed chromatin reader implicated in disease through germline loss-of-function mutations causing cognitive disability syndromes and somatic mutations are predominantly observed in acute T-cell leukemia. Previous re…
View article: RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition Open
High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identifica…
View article: Orthogonal proteomics methods to unravel the HOTAIR interactome
Orthogonal proteomics methods to unravel the HOTAIR interactome Open
Accumulating evidence highlights the role of long non-coding RNAs (lncRNAs) in cellular homeostasis, and their dysregulation in disease settings. Most lncRNAs function by interacting with proteins or protein complexes. While several orthog…
View article: Correction to: The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival
Correction to: The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival Open
View article: Proteome Profiling of RNF213 Depleted Cells Reveals Nitric Oxide Regulator DDAH1 Antilisterial Activity
Proteome Profiling of RNF213 Depleted Cells Reveals Nitric Oxide Regulator DDAH1 Antilisterial Activity Open
RNF213 is a large, poorly characterized interferon-induced protein. Mutations in RNF213 are associated with predisposition for Moyamoya disease (MMD), a rare cerebrovascular disorder. Recently, RNF213 was found to have broad antimicrobial …
View article: Orthogonal Proteomics Methods to Unravel the HOTAIR Interactome
Orthogonal Proteomics Methods to Unravel the HOTAIR Interactome Open
Accumulating evidence highlights the role of long non-coding RNAs (lncRNA) in cellular homeostasis, and their dysregulation in disease settings. Most lncRNAs function by interacting with proteins or protein complexes. While several orthogo…
View article: mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells
mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells Open
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Due to a lack of effective treatments, patients with metastatic disease have a median survival time of 6-12 months. We recently demonstrated that the SAMMSON …
View article: The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival
The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival Open
View article: The long non-coding RNA<i>SAMMSON</i>is essential for uveal melanoma cell survival
The long non-coding RNA<i>SAMMSON</i>is essential for uveal melanoma cell survival Open
Purpose Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression profiles, making them highly attractive as therapeutic targets. Pan-cancer RNA sequencing data revealed broad expression of the SAMMSON lncRNA…
View article: RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma
RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma Open
Summary Neuroblastoma is a pediatric tumor originating from the sympathetic nervous system responsible for 10-15 percent of all childhood cancer deaths. Half of all neuroblastoma patients present with high-risk disease at diagnosis. Despit…
View article: mTor inhibitor GDC-0349 improves ASO induced SAMMSON knock down resulting in enhanced anti-tumor efficacy in uveal melanoma
mTor inhibitor GDC-0349 improves ASO induced SAMMSON knock down resulting in enhanced anti-tumor efficacy in uveal melanoma Open
Uveal melanoma (UM) is the most common intraocular malignancy in adults. The lack of an effective treatment results in a median survival time of less than one year for patients with metastatic disease and shows the high unmet need for the …