Louis J. Soslowsky
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View article: Knockout of collagen V in development, but not in skeletal maturity, leads to long-term deficits in supraspinatus tendon mechanics in mice
Knockout of collagen V in development, but not in skeletal maturity, leads to long-term deficits in supraspinatus tendon mechanics in mice Open
Collagen V is a key matrix protein involved in fibril nucleation and lateral fibril growth during extracellular matrix assembly. Genetic mouse models have been used to investigate the role of collagen V in tendon, which showed deficient me…
View article: Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons
Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons Open
Tendons are soft musculoskeletal tissues that transfer tensile loads from muscle to bone and consist of a highly organized extracellular matrix. Highly and repetitively loaded tendons such as the Achilles tendon are more susceptible to inj…
View article: Sixteen weeks of high-speed treadmill running is insufficient to induce Achilles tendinopathy in a rat model
Sixteen weeks of high-speed treadmill running is insufficient to induce Achilles tendinopathy in a rat model Open
We demonstrated that 16 wk of high-speed treadmill running did not induce structural, functional, or mechanical changes consistent with Achilles tendinopathy in the rat. These findings underscore the importance of exploring alternative app…
View article: Mature murine supraspinatus tendons demonstrate regional differences in multiscale structure, function and gene expression
Mature murine supraspinatus tendons demonstrate regional differences in multiscale structure, function and gene expression Open
The hierarchical structure of tendon dictates its ability to effectively transmit loads from muscle to bone. Tendon- and site-specific differences in mechanical loading result in the establishment and remodeling of structure, as well as as…
View article: Moderate‐ and High‐Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon
Moderate‐ and High‐Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon Open
Exercise influences clinical Achilles tendon health in humans, but animal models of exercise‐related Achilles tendon changes are lacking. Moreover, previous investigations of the effects of treadmill running exercise on rat Achilles tendon…
View article: Learning on a Limb: An outreach module to engage high school students in orthopaedics
Learning on a Limb: An outreach module to engage high school students in orthopaedics Open
Orthopaedic researchers need new strategies for engaging underrepresented minority (URM) students. Our field has demonstrated noticeable gaps in racial, ethnic, and gender diversity, which inhibit our ability to innovate and combat the sev…
View article: Learning on a Limb: An outreach module to engage high school students in orthopaedics
Learning on a Limb: An outreach module to engage high school students in orthopaedics Open
Orthopaedic researchers need new strategies for engaging diverse students. Our field has demonstrated noticeable gaps in racial, ethnic, and gender diversity, which inhibit our ability to innovate and combat the severe socioeconomic burden…
View article: Focal adhesion kinase regulates tendon cell mechanoresponse and physiological tendon development
Focal adhesion kinase regulates tendon cell mechanoresponse and physiological tendon development Open
Tendons enable locomotion by transmitting high tensile mechanical forces between muscle and bone via their dense extracellular matrix (ECM). The application of extrinsic mechanical stimuli via muscle contraction is necessary to regulate he…
View article: In Vivo Photoacoustic Ultrasound (PAUS) Assay for Monitoring Tendon Collagen Compositional Changes during Injury and Healing
In Vivo Photoacoustic Ultrasound (PAUS) Assay for Monitoring Tendon Collagen Compositional Changes during Injury and Healing Open
Tendon injury and healing involve significant changes to tissue biology and composition. Current techniques often require animal sacrifice or tissue destruction, limiting assessment of dynamic changes in tendons, including treatment respon…
View article: Collagen V haploinsufficiency in female murine patellar tendons results in altered matrix engagement and cellular density, demonstrating decreased healing
Collagen V haploinsufficiency in female murine patellar tendons results in altered matrix engagement and cellular density, demonstrating decreased healing Open
Collagen V (Col5) is a quantitatively minor component of collagen fibrils comprising tendon, however, plays a crucial role in regulation of development and dynamic healing processes. Clinically, patients with COL5a1 haploinsufficiency, kno…
View article: Novel application of in vivo microdialysis in a rat Achilles tendon acute injury model
Novel application of in vivo microdialysis in a rat Achilles tendon acute injury model Open
This study adapts a novel application of microdialysis to rat tendon models, offering a minimally invasive avenue for longitudinal tendon assessment. Successfully detecting changes in tendon healing after acute injury, it showcases strong …
View article: Special issue: Guiding the future of tendon research
Special issue: Guiding the future of tendon research Open
We are pleased to present this Special Issue on Guiding the Future of Tendon Research. The perspectives, reviews, and original research papers in this issue were generated based on discussions and research presented at the Orthopaedic Rese…
View article: Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how)
Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how) Open
Several tendon and ligament animal models were presented at the 2022 Orthopaedic Research Society Tendon Section Conference held at the University of Pennsylvania, May 5 to 7, 2022. A key objective of the breakout sessions at this meeting …
View article: Knockdown of biglycan reveals an important role in maintenance of structural and mechanical properties during tendon aging
Knockdown of biglycan reveals an important role in maintenance of structural and mechanical properties during tendon aging Open
Biglycan, a small leucine‐rich proteoglycan (SLRP), is involved in collagen fibrillogenesis and also acts as a signaling molecule. Although decorin has been considered as the primary SLRP in developing and maintaining tendon structure and …
View article: Targeted conditional collagen XII deletion alters tendon function
Targeted conditional collagen XII deletion alters tendon function Open
View article: Post-injury tendon mechanics are not affected by tamoxifen treatment
Post-injury tendon mechanics are not affected by tamoxifen treatment Open
Overall, this study revealed that tamoxifen treatment at the time of tendon injury did not result in changes to tendon mechanics or the histological parameters at 3 weeks post-injury.
View article: Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression
Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression Open
Decorin and biglycan are two major small leucine-rich proteoglycans (SLRPs) present in the tendon extracellular matrix that facilitate collagen fibrillogenesis, tissue turnover, and cell signal transduction. Previously, we demonstrated tha…
View article: The Non-pregnant and Pregnant Human Cervix: a Systematic Proteomic Analysis
The Non-pregnant and Pregnant Human Cervix: a Systematic Proteomic Analysis Open
View article: Biglycan has a major role in maintenance of mature tendon mechanics
Biglycan has a major role in maintenance of mature tendon mechanics Open
Decorin and biglycan are two small leucine‐rich proteoglycans (SLRPs) that regulate collagen fibrillogenesis and extracellular matrix assembly in tendon. The objective of this study was to determine the individual roles of these molecules …
View article: Coordinate roles for collagen VI and biglycan in regulating tendon collagen fibril structure and function
Coordinate roles for collagen VI and biglycan in regulating tendon collagen fibril structure and function Open
Tendon is a vital musculoskeletal tissue that is prone to degeneration. Proper tendon maintenance requires complex interactions between extracellular matrix components that remain poorly understood. Collagen VI and biglycan are two matrix …
View article: Nonsurgical treatment reduces tendon inflammation and elevates tendon markers in early healing
Nonsurgical treatment reduces tendon inflammation and elevates tendon markers in early healing Open
Operative treatment is assumed to provide superior outcomes to nonoperative (conservative) treatment following Achilles tendon rupture, however, this remains controversial. This study explores the effect of surgical repair on Achilles tend…
View article: Collagen Dysregulation in the Dermis of the Sagg/+ Mouse: A Loose Skin Model
Collagen Dysregulation in the Dermis of the Sagg/+ Mouse: A Loose Skin Model Open
The Sagg/+ mouse is an ethylnitrosourea-derived mutant with a dermal phenotype similar to some of the subtypes of Ehlers-Danlos syndrome (EDS) and cutis laxa. The dermis of the Sagg/+ mouse has less dense and more disorganized collagen fib…
View article: Pulsed electromagnetic field therapy alters early healing in a rat model of rotator cuff injury and repair: Potential mechanisms
Pulsed electromagnetic field therapy alters early healing in a rat model of rotator cuff injury and repair: Potential mechanisms Open
Rotator cuff repair failure remains common due to poor tendon healing, particularly at the enthesis. We previously showed that pulsed electromagnetic field (PEMF) therapy improved the mechanical properties of the rat supraspinatus tendon p…
View article: Limited Scar Resection for Chronic Achilles Tendon Repair: Use of a Rat Model
Limited Scar Resection for Chronic Achilles Tendon Repair: Use of a Rat Model Open
Background: Achilles tendon rupture diagnosis is frequently missed, leading to the development of a chronic rupture that requires surgical intervention to remove scar tissue and return the elongated Achilles tendon to appropriate functiona…
View article: Reticulocalbin 3 is involved in postnatal tendon development by regulating collagen fibrillogenesis and cellular maturation
Reticulocalbin 3 is involved in postnatal tendon development by regulating collagen fibrillogenesis and cellular maturation Open
View article: Mechanical properties of the different rotator cuff tendons in the rat are similarly and adversely affected by age
Mechanical properties of the different rotator cuff tendons in the rat are similarly and adversely affected by age Open
View article: Liquid Poly-N-acetyl Glucosamine (sNAG) Improves Achilles Tendon Healing in a Rat Model
Liquid Poly-N-acetyl Glucosamine (sNAG) Improves Achilles Tendon Healing in a Rat Model Open
View article: Chronic Nicotine Exposure Minimally Affects Rat Supraspinatus Tendon Properties and Bone Microstructure
Chronic Nicotine Exposure Minimally Affects Rat Supraspinatus Tendon Properties and Bone Microstructure Open
View article: Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function
Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function Open
View article: Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon
Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon Open
Collagen XI is a fibril-forming collagen that regulates collagen fibrillogenesis. Collagen XI is normally associated with collagen II-containing tissues such as cartilage, but it also is expressed broadly during development in collagen I-c…