Louise Cornmark
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View article: Loss of <scp><i>NF2</i></scp> defines a genetic subgroup of <scp>non‐<i>FOS</i></scp>‐rearranged osteoblastoma
Loss of <span><i>NF2</i></span> defines a genetic subgroup of <span>non‐<i>FOS</i></span>‐rearranged osteoblastoma Open
Osteoblastoma is a locally aggressive tumour of bone. Until recently, its underlying genetic features were largely unknown. During the past two years, reports have demonstrated that acquired structural variations affect the transcription f…
View article: Dysregulated gene expression through<i>TP53</i>promoter swapping in osteosarcoma
Dysregulated gene expression through<i>TP53</i>promoter swapping in osteosarcoma Open
How massive genome rearrangements confer a competitive advantage to a cancer cell has remained an enigma. The malignant bone tumour osteosarcoma harbours an extreme number of structural variations and thereby holds the key to understand co…
View article: Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions
Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions Open
Our data demonstrate that the Smac-PKCδ interaction is direct and that it is facilitated by an open conformation of PKCδ. The binding is mediated via the PKCδ regulatory domain and both the C1 and C2 domains have Smac-binding capacity. Wit…
View article: New light on Smac mimetics and breast cancer
New light on Smac mimetics and breast cancer Open
The evasion of cell death is an important contribution to cancer development and may also confer resistance to chemo and radiotherapy.1 Therefore, reinstating a functional cell death machinery is one potential strategy for cancer therapy. …
View article: PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics
PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics Open