Louise Cullen
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View article: eLife Assessment: Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization
eLife Assessment: Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization Open
View article: Health Services and Economic Impacts of the Limit of Detection in Emergency Department ( <scp>LEGEND</scp> ) Rule‐Out Strategy in Australian Emergency Departments: A Stepped‐Wedge Cluster Randomised Trial
Health Services and Economic Impacts of the Limit of Detection in Emergency Department ( <span>LEGEND</span> ) Rule‐Out Strategy in Australian Emergency Departments: A Stepped‐Wedge Cluster Randomised Trial Open
Objective This study aimed to describe healthcare utilisation and costs associated with the assessment of suspected acute coronary syndrome (ACS) under standard care and to compare these outcomes with the Limit of Detection in Emergency De…
View article: 062 NUDG-ED: a 2x2 factorial, before-after, cluster randomised trial using behavioural nudges to reduce overdiagnosis and overtreatment of back pain in the emergency department
062 NUDG-ED: a 2x2 factorial, before-after, cluster randomised trial using behavioural nudges to reduce overdiagnosis and overtreatment of back pain in the emergency department Open
View article: High-sensitivity point-of-care measurement of cardiac troponin
High-sensitivity point-of-care measurement of cardiac troponin Open
New technologies enabling access to high-sensitivity cardiac troponin (hs-cTn) assays at the point of care (POC) are available for routine use. POC technology can accelerate cardiac troponin testing within the hospital setting and support …
View article: Implementing best practice for peripheral intravenous cannula use in Australian emergency departments: a stepped-wedge cluster-controlled trial and health economic analysis protocol
Implementing best practice for peripheral intravenous cannula use in Australian emergency departments: a stepped-wedge cluster-controlled trial and health economic analysis protocol Open
Introduction Over one billion adults attend emergency departments (EDs) internationally every year, including 6.6 million in Australia. Up to half of these patients have a peripheral intravenous catheter (PIVC) inserted. Although healthcar…
View article: eLife Assessment: Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization
eLife Assessment: Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization Open
View article: Effectiveness of Point-of-Care High-Sensitivity Troponin Testing in the Emergency Department: A Randomized Controlled Trial
Effectiveness of Point-of-Care High-Sensitivity Troponin Testing in the Emergency Department: A Randomized Controlled Trial Open
We found that implementing point-of-care hs-cTnI testing in the ED with a 0/1-hour diagnostic algorithm did not lead to a clinically meaningful reduction in ED LOS. We observed no difference in the incidence of myocardial infarction, acute…
View article: Potential length of stay reductions from emergency department use of a point‐of‐care high‐sensitivity cardiac troponin assay: Pilot findings from Australia's first cardiac emergency department
Potential length of stay reductions from emergency department use of a point‐of‐care high‐sensitivity cardiac troponin assay: Pilot findings from Australia's first cardiac emergency department Open
Objective To compare actual ED length of stay (LOS) using laboratory‐based high‐sensitivity cardiac troponin I (hs‐cTnI) testing with the potential LOS that could result from using point‐of‐care (POC) hs‐cTnI tests. Methods Baseline hs‐cTn…
View article: Empowering rural emergency physicians: POCUS as a diagnostic lifeline
Empowering rural emergency physicians: POCUS as a diagnostic lifeline Open
View article: Re-engineering the clinical approach to suspected cardiac chest pain assessment in the emergency department by expediting research evidence to practice using artificial intelligence. (RAPIDx AI)—a cluster randomized study design
Re-engineering the clinical approach to suspected cardiac chest pain assessment in the emergency department by expediting research evidence to practice using artificial intelligence. (RAPIDx AI)—a cluster randomized study design Open
ANZCTR, Registration Number: ACTRN12620001319965, https://www.anzctr.org.au/.
View article: Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study
Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study Open
The German Center for Cardiovascular Research (DZHK).
View article: Machine-Learning for Phenotyping and Prognostication of Myocardial Infarction and Injury in Suspected Acute Coronary Syndrome
Machine-Learning for Phenotyping and Prognostication of Myocardial Infarction and Injury in Suspected Acute Coronary Syndrome Open
Machine learning models can digitally phenotype suspected ACS patients at index presentation and predict subsequent events within 30 days. These models require external validation in a randomized clinical trial to evaluate their impact in …
View article: Clinical decision support using machine learning and natriuretic peptides for the diagnosis of acute heart failure
Clinical decision support using machine learning and natriuretic peptides for the diagnosis of acute heart failure Open
View article: Behavioural ‘nudging’ interventions to reduce low-value care for low back pain in the emergency department (NUDG-ED): protocol for a 2×2 factorial, before-after, cluster randomised trial
Behavioural ‘nudging’ interventions to reduce low-value care for low back pain in the emergency department (NUDG-ED): protocol for a 2×2 factorial, before-after, cluster randomised trial Open
Introduction Opioids and imaging are considered low-value care for most people with low back pain. Yet around one in three people presenting to the emergency department (ED) will receive imaging, and two in three will receive an opioid. NU…
View article: COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals
COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals Open
View article: Integrating POC markers into the ED
Integrating POC markers into the ED Open
View article: Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification
Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification Open
Background Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways prevent unnecessa…
View article: DART 3: A pragmatic stepped wedge cluster randomised trial of ultrasound guidance to reducing multiple PIVC insertions in hospitalised patients
DART 3: A pragmatic stepped wedge cluster randomised trial of ultrasound guidance to reducing multiple PIVC insertions in hospitalised patients Open
View article: Impacts of high sensitivity troponin T reporting on care and outcomes in clinical practice: Interactions between low troponin concentrations and participant sex within two randomized clinical trials
Impacts of high sensitivity troponin T reporting on care and outcomes in clinical practice: Interactions between low troponin concentrations and participant sex within two randomized clinical trials Open
View article: Background rates of adverse events of special interest for COVID-19 vaccines: A multinational Global Vaccine Data Network (GVDN) analysis
Background rates of adverse events of special interest for COVID-19 vaccines: A multinational Global Vaccine Data Network (GVDN) analysis Open
View article: Suspected myocardial infarction in the emergency department: An evaluation of clinical thresholds for the Beckman Coulter Access <scp>hsTnI</scp> high‐sensitivity cardiac troponin I assay
Suspected myocardial infarction in the emergency department: An evaluation of clinical thresholds for the Beckman Coulter Access <span>hsTnI</span> high‐sensitivity cardiac troponin I assay Open
Objective The primary objective was to determine rapid rule‐out (RRO) criteria for the outcome of myocardial infarction (MI) using the Beckman Coulter Access high‐sensitivity cardiac troponin I (hs‐cTnI) assay. Secondary objectives were to…
View article: Improving difficult peripheral intravenous access requires thought, training and technology (DART3): a stepped-wedge, cluster randomised controlled trial protocol
Improving difficult peripheral intravenous access requires thought, training and technology (DART3): a stepped-wedge, cluster randomised controlled trial protocol Open
View article: Personalized diagnosis in suspected myocardial infarction
Personalized diagnosis in suspected myocardial infarction Open
Background In suspected myocardial infarction (MI), guidelines recommend using high-sensitivity cardiac troponin (hs-cTn)-based approaches. These require fixed assay-specific thresholds and timepoints, without directly integrating clinical…
View article: Chest Pain Management Using Prehospital Point-of-Care Troponin and Paramedic Risk Assessment
Chest Pain Management Using Prehospital Point-of-Care Troponin and Paramedic Risk Assessment Open
Importance Prehospital point-of-care troponin testing and paramedic risk stratification might improve the efficiency of chest pain care pathways compared with existing processes with equivalent health outcomes, but the association with hea…
View article: Acute cardiovascular care in the emergency department and beyond: a call for interdisciplinary collaboration in clinical research
Acute cardiovascular care in the emergency department and beyond: a call for interdisciplinary collaboration in clinical research Open
Providing optimal care to patients in the emergency department (ED) requires teamwork and interdisciplinary collaboration. This need holds true for patients with a wide range of conditions, particularly those with acute cardiovascular (CV)…
View article: Clinical characteristics of Aboriginal and Torres Strait Islander emergency department patients with suspected acute coronary syndrome
Clinical characteristics of Aboriginal and Torres Strait Islander emergency department patients with suspected acute coronary syndrome Open
Objectives To describe the demographics, presentation characteristics, clinical features and cardiac outcomes for Aboriginal and Torres Strait Islander patients who present to a regional cardiac referral centre ED with suspected acute coro…
View article: Snapshot of suspected acute coronary syndrome assessment processes in the emergency department: A national cross‐sectional survey
Snapshot of suspected acute coronary syndrome assessment processes in the emergency department: A national cross‐sectional survey Open
Objective The Snapshot of Suspected ACS Assessment (SSAASY) study aims to describe the assessment processes for patients with suspected acute coronary syndrome (ACS) in Australian EDs, and to compare these processes with the National Heart…
View article: Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain
Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain Open
Background Elevations of high-sensitivity cardiac troponin (hs-cTn) concentrations not related to type 1 myocardial infarction are common in chest pain patients presenting to emergency departments. The discrimination of these patients from…
View article: Cardiac biomarkers in the field of cardio-oncology
Cardiac biomarkers in the field of cardio-oncology Open
View article: Machine learning to optimise use of cardiac troponin in the diagnosis of acute myocardial infarction
Machine learning to optimise use of cardiac troponin in the diagnosis of acute myocardial infarction Open
Background Guidelines recommend fixed cardiac troponin thresholds for the assessment of patients with suspected acute coronary syndrome, however, performance varies in important patient groups as concentrations are influenced by age, sex a…