Louise F. Kimura
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View article: Methods to assess neuronal primary cilia electrochemical signaling
Methods to assess neuronal primary cilia electrochemical signaling Open
Primary cilia are polymodal sensory organelles which project from the apical side of polarized cells. They are found in all brain hemispheres but are most pronounced in neurons which comprise the granular layers of the hippocampus and cere…
View article: Methods to Assess Neuronal Primary Cilia Electrochemical Signaling
Methods to Assess Neuronal Primary Cilia Electrochemical Signaling Open
Primary cilia are polymodal sensory organelles which project from the apical side of polarized cells. They are found in all brain hemispheres but are most pronounced in neurons, which comprise the granular layers of the hippocampus and cer…
View article: Primary cilia TRP channel regulates hippocampal excitability
Primary cilia TRP channel regulates hippocampal excitability Open
Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. Most notably, PKD2 dysregulation in the kidney nephron cilia is associated with polycystic kidney disease, but …
View article: Crotalphine Modulates Microglia M1/M2 Phenotypes and Induces Spinal Analgesia Mediated by Opioid-Cannabinoid Systems
Crotalphine Modulates Microglia M1/M2 Phenotypes and Induces Spinal Analgesia Mediated by Opioid-Cannabinoid Systems Open
Pain is a worldwide public health problem and its treatment is still a challenge since clinically available drugs do not completely reverse chronic painful states or induce undesirable effects. Crotalphine is a 14 amino acids synthetic pep…
View article: Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain
Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain Open
Voltage-gated sodium channels (NaV) in nociceptive neurons initiate action potentials required for transmission of aberrant painful stimuli observed in osteoarthritis (OA). Targeting NaV subtypes with drugs to produce…
View article: COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study
COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study Open
View article: How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders
How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders Open
Depression and anxiety commonly occur in chronic pain states and the coexistence of these diseases worsens outcomes for both disorders and may reduce treatment adherence and response. Despite the advances in the knowledge of chronic pain m…
View article: The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions
The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions Open
Crotoxin (CTX), the main neurotoxin from Crotalus durissus terrificus snake venom, has anti-inflammatory, immunomodulatory and antinociceptive activities. However, the CTX-induced toxicity may compromise its use. Under this scenario…
View article: Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice
Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice Open
Neuropathic pain is a disease caused by structural and functional plasticity in central and peripheral sensory pathways that produce alterations in nociceptive processing. Currently, pharmacological treatment for this condition remains a c…
View article: Biochemical and biological characterization of<i>Bothriechis schlegelii</i>snake venoms from Colombia and Costa Rica
Biochemical and biological characterization of<i>Bothriechis schlegelii</i>snake venoms from Colombia and Costa Rica Open
Snakebites inflicted by the arboreal viperid snake Bothriechis schlegelii in humans are characterized by pain, edema, and ecchymosis at the site of the bite, rarely with blisters, local necrosis, or defibrination. Herein, a comparative stu…