Louise McCombie
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View article: Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial
Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial Open
Background Overweight and obesity affect over 60% of the United Kingdom population and constitute a major risk factor for the development of comorbidities. Preventing weight gain in periods of life where there is an elevated risk of adipos…
View article: A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity
A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity Open
In this study, the use of a dietitian-supported weight management program resulted in sustained weight loss and is a potential treatment for obesity in asthma. The CWP resulted in a higher proportion achieving MCID improvements in AQLQ com…
View article: 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study
5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study Open
Diabetes UK.
View article: A Total Diet Replacement Weight Management Program for Difficult-to-Treat Asthma Associated With Obesity
A Total Diet Replacement Weight Management Program for Difficult-to-Treat Asthma Associated With Obesity Open
gov.
View article: Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby)
Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby) Open
We gratefully acknowledge funding for the MRI scans from the, Miss MJM Smith Trust (registered charity: SC040586). No other external funds were provided for this trial. NS is supported by the British Heart Foundation Research Excellence Aw…
View article: Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (<scp>DiRECT</scp>)
Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (<span>DiRECT</span>) Open
Aims As sustained weight loss is vital for achieving remission of type 2 diabetes, we explored whether randomisation to weight loss plus maintenance in the DiRECT trial was associated with physical activity, inactivity or sleep. Methods Pa…
View article: Increase in colonic PRopionate as a method of prEVENTing weight gain in adults aged 20–40 years (iPREVENT): protocol of a multi-centre, double-blind, randomised, parallel-group trial to investigate the efficacy of inulin-propionate ester versus inulin (control) in the prevention of weight gain over 12 months
Increase in colonic PRopionate as a method of prEVENTing weight gain in adults aged 20–40 years (iPREVENT): protocol of a multi-centre, double-blind, randomised, parallel-group trial to investigate the efficacy of inulin-propionate ester versus inulin (control) in the prevention of weight gain over 12 months Open
Introduction: Overweight and obesity affects over 70% of the UK population and is a major risk factor for the development of co-morbidities, including type 2 diabetes and cardiovascular disease. There now exists a considerable evidence bas…
View article: Participant experiences in the Diabetes REmission Clinical Trial (DiRECT)
Participant experiences in the Diabetes REmission Clinical Trial (DiRECT) Open
Introduction The Diabetes REmission Clinical Trial (DiRECT) has shown that sustained remission of type 2 diabetes in primary care is achievable through weight loss using total diet replacement (TDR) with continued behavioural support. Unde…
View article: Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT)
Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT) Open
Aims/hypothesis Our aim was to evaluate the safety and efficacy of a planned therapeutic withdrawal of all antihypertensive and diuretic medications, on commencing a formula low-energy diet replacement, targeting remission of type 2 diabet…
View article: Predictors of type 2 diabetes remission in the Diabetes Remission Clinical Trial (DiRECT)
Predictors of type 2 diabetes remission in the Diabetes Remission Clinical Trial (DiRECT) Open
Aim To identify predictors of type 2 diabetes remission in the intervention arm of DiRECT (Diabetes Remission Clinical Trial). Methods Participants were aged 20–65 years, with type 2 diabetes duration of <6 years and BMI 27–45 kg/m 2 , and…
View article: Diabetes and travel insurance costs: let's talk about remission
Diabetes and travel insurance costs: let's talk about remission Open
The growing global prevalence of type 2 diabetes mellitus places enormous burden on health services and affected individuals. As with other medical diagnoses, the presence of type 2 diabetes will impact on premiums for things such as trave…
View article: Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort
Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort Open
www.controlled-trials.com/ISRCTN03267836 ; date of registration 20 December 2013.