Lene Nielsen
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View article: Outcomes Related to Bacterial Co-Infection and Antibiotic Use in Adults Hospitalized With Respiratory Syncytial Virus Compared with Influenza
Outcomes Related to Bacterial Co-Infection and Antibiotic Use in Adults Hospitalized With Respiratory Syncytial Virus Compared with Influenza Open
Background Adults hospitalized with respiratory syncytial virus (RSV) face mortality risks comparable to or higher than those with influenza A or B. However, studies on the impact of bacterial co-infections on mortality are inconsistent. M…
View article: Clinical Manifestations and Outcomes in Adults Hospitalized With Respiratory Syncytial Virus and Influenza a/B: A Multicenter Observational Cohort Study
Clinical Manifestations and Outcomes in Adults Hospitalized With Respiratory Syncytial Virus and Influenza a/B: A Multicenter Observational Cohort Study Open
Background Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adu…
View article: Peripheral facial palsy in children: Serum Borrelia antibodies may reduce the need for lumbar puncture
Peripheral facial palsy in children: Serum Borrelia antibodies may reduce the need for lumbar puncture Open
Aim We aimed to investigate the causes of acute peripheral facial palsy (PFP) in Danish children and to explore whether neuroborreliosis‐related PFP could be diagnosed without lumbar puncture using clinical symptoms and serum Borrelia burg…
View article: High-resolution epidemiological landscape from ~290,000 SARS-CoV-2 genomes from Denmark
High-resolution epidemiological landscape from ~290,000 SARS-CoV-2 genomes from Denmark Open
Vast amounts of pathogen genomic, demographic and spatial data are transforming our understanding of SARS-CoV-2 emergence and spread. We examined the drivers of molecular evolution and spread of 291,791 SARS-CoV-2 genomes from Denmark in 2…
View article: Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta
Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta Open
Background Respiratory viral infections have significant global health impacts. We compared 30‐day intensive care unit (ICU) admission and all‐cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV…
View article: Vertical Transmission of SARS-CoV-2 is Plausible During Pregnancy and Vaginal Delivery: A Prospective Cohort Study
Vertical Transmission of SARS-CoV-2 is Plausible During Pregnancy and Vaginal Delivery: A Prospective Cohort Study Open
Objective: To evaluate if SARS-CoV-2 is detectable in vaginal swabs and whether antibodies against SARS-CoV-2 are present in maternal and umbilical cord blood of pregnant women with COVID-19. Design: Prospective cohort study. Setting: Depa…
View article: First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023
First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023 Open
We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate that the variant is circul…
View article: Introduction and transmission of SARS-CoV-2 lineage B.1.1.7, Alpha variant, in Denmark
Introduction and transmission of SARS-CoV-2 lineage B.1.1.7, Alpha variant, in Denmark Open
Background In early 2021, the SARS-CoV-2 lineage B.1.1.7 (Alpha variant) became dominant across large parts of the world. In Denmark, comprehensive and real-time test, contact-tracing, and sequencing efforts were applied to sustain epidemi…
View article: Is monotherapy with a beta-lactam antibiotic inferior to combination therapy with a beta-lactam antibiotic and rifampicin in treating prosthetic joint infections? A retrospective study.
Is monotherapy with a beta-lactam antibiotic inferior to combination therapy with a beta-lactam antibiotic and rifampicin in treating prosthetic joint infections? A retrospective study. Open
Background: The use of rifampicin in Prosthetic joint infections (PJI’s) is widely used, although the evidence of its effectiveness is sparce. The aim of this study was to retrospectively examine if monotherapy with a beta-lactam antibioti…
View article: Lung Function Decline in Relation to COVID-19 in the General Population: A Matched Cohort Study With Prepandemic Assessment of Lung Function
Lung Function Decline in Relation to COVID-19 in the General Population: A Matched Cohort Study With Prepandemic Assessment of Lung Function Open
Background To quantify the potential decline in dynamic lung volumes following coronavirus disease 2019 (COVID-19) in the general population. Methods A prospective matched cohort study of adult Copenhagen General Population Study (CGPS) pa…
View article: A prospective cohort study of confirmed severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection during pregnancy evaluating SARS‐CoV‐2 antibodies in maternal and umbilical cord blood and SARS‐CoV‐2 in vaginal swabs
A prospective cohort study of confirmed severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection during pregnancy evaluating SARS‐CoV‐2 antibodies in maternal and umbilical cord blood and SARS‐CoV‐2 in vaginal swabs Open
Introduction Evidence about the consequences of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in pregnancy is rapidly increasing; however, data on antibody response and risk of transmission during pregnancy and del…
View article: Electronic reporting of diagnostic laboratory test results from all healthcare sectors is a cornerstone of national preparedness and control of COVID‐19 in Denmark
Electronic reporting of diagnostic laboratory test results from all healthcare sectors is a cornerstone of national preparedness and control of COVID‐19 in Denmark Open
The COVID‐19 pandemic has led to an unprecedented demand for real‐time surveillance data in order to inform critical decision makers regarding the management of the pandemic. The aim of this review was to describe how the Danish national m…
View article: Comparison of 16 Serological SARS-CoV-2 Immunoassays in 16 Clinical Laboratories
Comparison of 16 Serological SARS-CoV-2 Immunoassays in 16 Clinical Laboratories Open
Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to support clinical diagnosis and epidemiological investigations. Recently, assays for large-scale detection of total antibodies (Ab), immunoglo…
View article: Characteristics and Long-term Prognosis of Danish Patients With Varicella Zoster Virus Detected in Cerebrospinal Fluid Compared With the Background Population
Characteristics and Long-term Prognosis of Danish Patients With Varicella Zoster Virus Detected in Cerebrospinal Fluid Compared With the Background Population Open
Background Risk factors for, and long-term outcomes following, detection of varicella zoster virus (VZV) DNA in the cerebrospinal fluid (CSF) are unknown. Methods We performed a nationwide population-based cohort study of all Danish reside…
View article: Comparison of sixteen serological SARS-CoV-2 immunoassays in sixteen clinical laboratories
Comparison of sixteen serological SARS-CoV-2 immunoassays in sixteen clinical laboratories Open
Serological SARS-CoV-2 assays are needed to support clinical diagnosis and epidemiological investigations. Recently, assays for the large-volume detection of total antibodies (Ab) and immunoglobulin (Ig) G and M against SARS-CoV-2 antigens…
View article: A case of reassortant seasonal influenza A(H1N2) virus, Denmark, April 2019
A case of reassortant seasonal influenza A(H1N2) virus, Denmark, April 2019 Open
A reassortant influenza A subtype H1N2 virus with gene segments from seasonal A(H1N1)pdm09 virus (HA, MP, NP, NS, PA, PB1 and PB2) and seasonal A(H3N2) virus (NA) was identified in a routine surveillance sample in Denmark. The patient reco…
View article: Treatment of candidemia in a nationwide setting: increased survival with primary echinocandin treatment
Treatment of candidemia in a nationwide setting: increased survival with primary echinocandin treatment Open
Karen Rokkedal Lausch,1 Mette Søgaard,2,3 Flemming Schønning Rosenvinge,4,5 Helle Krogh Johansen,6 Trine Boysen,7 Bent Løwe Røder,8 Klaus Leth Mortensen,1,9 Lene Nielsen,10 Lars Lemming,9 Bente Olesen,10 Christine Leitz,11 Lise Kristensen,…
View article: Treatment of candidemia in a nationwide setting: increased survival with primary echinocandin treatment
Treatment of candidemia in a nationwide setting: increased survival with primary echinocandin treatment Open
The association shown between prior AFT and non-albicans species underlines the importance of treatment history when selecting treatment for candidemia. Compliance with national recommendations was low, but similar to previously reported i…
View article: Update from a 12-Year Nationwide Fungemia Surveillance: Increasing Intrinsic and Acquired Resistance Causes Concern
Update from a 12-Year Nationwide Fungemia Surveillance: Increasing Intrinsic and Acquired Resistance Causes Concern Open
New data from the years 2012 to 2015 from the Danish National Fungemia Surveillance are reported, and epidemiological trends are investigated in a 12-year perspective (2004 to 2015). During 2012 to 2015, 1,900 of 1,939 (98%) fungal bloodst…
View article: Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 – a rapid epidemiological and virological assessment
Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 – a rapid epidemiological and virological assessment Open
In Denmark, both influenza A(H1N1)pdm09 and influenza B co-circulated in the 2015/16 season. We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine in patients 65 years and older using the test-negative case–control…