Explanipedia

Performance of established disease severity scores in predicting severe outcomes among adults hospitalized with influenza—FluSurv‐NET, 2017–2018 Open

Joshua Doyle, Shikha Garg, Alissa O’Halloran, Lauren Grant, Evan J. Anderson , et al. · 2023

Background Influenza is a substantial cause of annual morbidity and mortality; however, correctly identifying those patients at increased risk for severe disease is often challenging. Several severity indices have been developed; however, …

Epidemiology of Sepsis in US Children and Young Adults Open

Shelley S. Magill, Mathew R. P. Sapiano, Runa H. Gokhale, Joelle Nadle, Helen Johnston , et al. · 2023

Background Most multicenter studies of US pediatric sepsis epidemiology use administrative data or focus on pediatric intensive care units. We conducted a detailed medical record review to describe sepsis epidemiology in children and young…

Antimicrobial Use in a Cohort of US Nursing Homes, 2017 Open

Nicola D. Thompson, Nimalie D. Stone, Cedric Brown, Austin Penna, Taniece Eure , et al. · 2021

Importance Controlling antimicrobial resistance in health care is a public health priority, although data describing antimicrobial use in US nursing homes are limited. Objective To measure the prevalence of antimicrobial use and describe a…

Antibiotic Susceptibility of Common Organisms Isolated from Urine Cultures of Nursing Home Residents Open

Austin Penna, Taniece Eure, Nimalie D. Stone, Grant Barney, Devra Barter , et al. · 2020

Background: With the emergence of antibiotic resistant threats and the need for appropriate antibiotic use, laboratory microbiology information is important to guide clinical decision making in nursing homes, where access to such data can …

Appropriateness of Initiating Antibiotics for Urinary Tract Infection Among Nursing Home Residents Open

Taniece Eure, Nicola D. Thompson, Austin Penna, Wendy Bamberg, Grant Barney , et al. · 2020

Background: Antibiotics are among the most commonly prescribed drugs in nursing homes; urinary tract infections (UTIs) are a frequent indication. Although there is no gold standard for the diagnosis of UTIs, various criteria have been deve…

Prevalence and Epidemiology of Healthcare-Associated Infections (HAI) in US Nursing Homes (NH), 2017 Open

Nicola D. Thompson, Nimalie D. Stone, Cedric Brown, Taniece Eure, Austin Penna , et al. · 2020

Background: With an aging population, increasingly complex care, and frequent re-admissions, prevention of healthcare-associated infections (HAIs) in nursing homes (NHs) is a federal priority. However, few contemporary sources of HAI data …

Assessment of Health Care Exposures and Outcomes in Adult Patients With Sepsis and Septic Shock Open

Katherine Fay, Mathew R. P. Sapiano, Runa H. Gokhale, Raymund Dantes, Nicola D. Thompson , et al. · 2020

Importance Current information on the characteristics of patients who develop sepsis may help in identifying opportunities to improve outcomes. Most recent studies of sepsis epidemiology have focused on changes in incidence or have used ad…

Respiratory and Nonrespiratory Diagnoses Associated With Influenza in Hospitalized Adults Open

Eric J. Chow, Melissa A. Rolfes, Alissa O’Halloran, Nisha B. Alden, Evan J. Anderson , et al. · 2020

Nonrespiratory diagnoses occurred frequently among adults hospitalized with influenza, further contributing to the burden of infection in the United States. The findings suggest that during the influenza season, practitioners should consid…

Epidemiology of Antibiotic Use for Urinary Tract Infection in Nursing Home Residents Open

Nicola D. Thompson, Austin Penna, Taniece Eure, Wendy Bamberg, Grant Barney , et al. · 2019

2741. Seasonal Influenza Vaccine Timing in Children and Adults Hospitalized with Influenza in the United States, FluSurv-NET, 2013–2017 Open

Julia C. Haston, Shikha Garg, Angela P. Campbell, Jill M. Ferdinands, Alissa O’Halloran , et al. · 2019

Background Seasonal influenza vaccine may attenuate disease severity among people infected with influenza despite vaccination, but vaccine effectiveness may decrease with increasing time between vaccination and infection. Patient character…

898. Influenza Vaccination Reduces Risk of Severe Outcomes among Adults Hospitalized with Influenza A(H1N1)pdm09, FluSurv-NET, 2013–2018 Open

Shikha Garg, Lauren Beacham, Carmen Sofia Arriola, Alissa O’Halloran, Charisse N Cummings , et al. · 2019

Background Influenza vaccination may reduce illness severity among those with influenza; however, data are limited. We determined whether outcomes were less severe among vaccinated compared with unvaccinated adults hospitalized with influe…

LB19. Patterns of Influenza A Hospitalizations by Subtype and Age in the United States, FluSurv-NET, 2018–2019 Open

Shikha Garg, Alissa O’Halloran, Alissa O’Halloran, Charisse N Cummings, Charisse N Cummings , et al. · 2019

Background The 2018–19 influenza season was characterized by prolonged co-circulation of Influenza A H3N2 (H3) and H1N1pdm09 (H1) viruses. We used data from the Influenza Hospitalization Surveillance Network (FluSurv-NET) to describe age-r…

1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018 Open

Eric J. Chow, Melissa A. Rolfes, Alissa O’Halloran, Evan J. Anderson, Nancy M. Bennett , et al. · 2019

Background Influenza virus infection most commonly causes acute respiratory tract illness, however may also lead to non-respiratory complications including acute cardiovascular (CV) events. We describe the frequency of and risk factors for…

94. Pneumonia Severity Scores Poorly Predict Severe Outcomes Among Adults Hospitalized with Influenza Open

Joshua Doyle, Shikha Garg, Alissa O’Halloran, Lauren Beacham, Charisse N Cummings , et al. · 2019

Background Influenza can lead to severe outcomes among adults hospitalized with influenza, and causes substantial annual morbidity and mortality. We evaluated the performance of validated pneumonia severity indices in predicting severe inf…

111. Pediatric and Adolescent Sepsis Epidemiology and Clinical Characteristics, Emerging Infections Program, 2014–2015 Open

Runa H. Gokhale, Matthew Sapiano, Raymund Dantes, Francisca Abanyie-Bimbo, Lucy Wilson , et al. · 2019

Background Sepsis is an important contributor to mortality among children and young adults. However, recent studies focused on hospital management and burden estimation do not provide critical data to inform prevention efforts. We conducte…

1831. Point Prevalence and Epidemiology of Antimicrobial Use in US Nursing Homes, 2017 Open

Nicola D. Thompson, Cedric Brown, Taniece Eure, Austin Penna, Wendy Bamberg , et al. · 2018

Background The role of nursing homes (NH) in transmission of antimicrobial-resistant (AR) organisms is of growing concern. AR control requires evidence-based NH stewardship interventions; however, data on antimicrobial use (AU) from US NHs…

1836. Characteristics of Nursing Homes Associated With Self-reported Implementation of Centers for Disease Control and Prevention (CDC) Core Elements of Antibiotic Stewardship Open

Nicola D. Thompson, Cedric Brown, Taniece Eure, Austin Penna, Grant Barney , et al. · 2018

Background CDC released the Core Elements of Antibiotic Stewardship (Core Elements) for Nursing Homes (NHs) in 2015. In 2017, CDCs Emerging Infections Program (EIP) evaluated uptake of the Core Elements in a cohort of NHs. Methods NHs from…

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