Loyal A. Goff
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View article: <i>Rroid2</i> regulates effector-to-memory CD8 <sup>+</sup> T cell differentiation during infection in vivo
<i>Rroid2</i> regulates effector-to-memory CD8 <sup>+</sup> T cell differentiation during infection in vivo Open
CD8 + T cell differentiation has been associated with changes in the expression of long noncoding RNAs (lncRNAs). Yet, which and how lncRNAs regulate CD8 + T cell responses following infection in vivo remains incompletely understood. We pe…
View article: A consensus definition for deep layer 6 excitatory neurons in mouse somatosensory, visual, and motor cortex
A consensus definition for deep layer 6 excitatory neurons in mouse somatosensory, visual, and motor cortex Open
To understand neocortical function, it is helpful to define cortical cell types. Recent studies indicate that neurons in the deepest cortical layer play roles in mediating thalamocortical interactions and modulating brain state and are imp…
View article: A consensus definition for deep layer 6 excitatory neurons in mouse neocortex
A consensus definition for deep layer 6 excitatory neurons in mouse neocortex Open
To understand neocortical function, we must first define its cell types. Recent studies indicate that neurons in the deepest cortical layer play roles in mediating thalamocortical interactions and modulating brain state and are implicated …
View article: Retinal ganglion cell-derived semaphorin 6A segregates starburst amacrine cell dendritic scaffolds to organize the mouse inner retina
Retinal ganglion cell-derived semaphorin 6A segregates starburst amacrine cell dendritic scaffolds to organize the mouse inner retina Open
To form functional circuits, neurons must settle in their appropriate cellular locations, and then project and elaborate neurites to contact their target synaptic neuropils. Laminar organization within the vertebrate retinal inner plexifor…
View article: Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan
Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan Open
Oligodendrocyte progenitor cells (OPCs) are highly dynamic, widely distributed glial cells of the central nervous system (CNS) that are responsible for generating myelinating oligodendrocytes during development. By also generating new olig…
View article: Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion
Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion Open
The neocortex varies in size and complexity among mammals due to the tremendous variability in the number and diversity of neuronal subtypes across species. The increased cellular diversity is paralleled by the expansion of the pool of neo…
View article: Multi-sample non-negative spatial factorization
Multi-sample non-negative spatial factorization Open
Analyzing multi-sample spatial transcriptomics data requires accounting for biological variation. We present multi-sample non-negative spatial factorization (mNSF), an alignment-free framework extending single-sample spatial factorization …
View article: Physiological regulation of neuronal Wnt activity is essential for TDP-43 localization and function
Physiological regulation of neuronal Wnt activity is essential for TDP-43 localization and function Open
Nuclear exclusion of the RNA- and DNA-binding protein TDP-43 can induce neurodegeneration in different diseases. Diverse processes have been implicated to influence TDP-43 mislocalization, including disrupted nucleocytoplasmic transport (N…
View article: Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture
Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture Open
Background Trans-differentiation of human-induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons a likely significant advance for disease modeling and in vitro as…
View article: Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease
Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease Open
The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cel…
View article: Semaphorin 6A in Retinal Ganglion Cells Regulates Functional Specialization of the Inner Retina
Semaphorin 6A in Retinal Ganglion Cells Regulates Functional Specialization of the Inner Retina Open
To form functional circuits, neurons must settle in their appropriate cellular locations and then project and elaborate neurites to contact their target synaptic neuropils. Laminar organization within the vertebrate retinal inner plexiform…
View article: BRN1/2 Function in Neocortical Size Determination and Microcephaly
BRN1/2 Function in Neocortical Size Determination and Microcephaly Open
The mammalian neocortex differs vastly in size and complexity between mammalian species, yet the mechanisms that lead to an increase in brain size during evolution are not known. We show here that two transcription factors coordinate gene …
View article: Pumping the brakes on RNA velocity by understanding and interpreting RNA velocity estimates
Pumping the brakes on RNA velocity by understanding and interpreting RNA velocity estimates Open
Background RNA velocity analysis of single cells offers the potential to predict temporal dynamics from gene expression. In many systems, RNA velocity has been observed to produce a vector field that qualitatively reflects known features o…
View article: Normal and Sjogren’s syndrome models of the murine lacrimal gland studied at single-cell resolution
Normal and Sjogren’s syndrome models of the murine lacrimal gland studied at single-cell resolution Open
The lacrimal gland is of central interest in ophthalmology both as the source of the aqueous component of tear fluid and as the site of autoimmune pathology in the context of Sjogren’s syndrome (SjS). To provide a foundational description …
View article: <i>Ret</i> deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development
<i>Ret</i> deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development Open
The receptor tyrosine kinase RET plays a critical role in the fate specification of enteric neural crest–derived cells (ENCDCs) during enteric nervous system (ENS) development. RET loss of function (LoF) is associated with Hirschsprung dis…
View article: Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease
Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease Open
The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cel…
View article: Author Response: Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease
Author Response: Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease Open
The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cel…
View article: Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease
Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease Open
The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cel…
View article: Psychedelics reopen the social reward learning critical period
Psychedelics reopen the social reward learning critical period Open
Psychedelics are a broad class of drugs defined by their ability to induce an altered state of consciousness 1,2 . These drugs have been used for millennia in both spiritual and medicinal contexts, and a number of recent clinical successes…
View article: Data from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
Data from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data Open
Tumor heterogeneity provides a complex challenge to cancer treatment and is a critical component of therapeutic response, disease recurrence, and patient survival. Single-cell RNA-sequencing (scRNA-seq) technologies have revealed the preva…
View article: Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data Open
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
View article: Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data Open
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
View article: Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data Open
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
View article: Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data Open
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
View article: Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data Open
Supplementary Table from Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data