Explanipedia

A mixed-methods scoping review on bladder self-care practices in women with and without lower urinary tract symptoms Open

Jean F. Wyman, Kristine Mc Talley, Melanie Meister, Diane K. Newman, Amy M. Claussen , et al. · 2025

Bladder health and the urogenital microbiome in community-dwelling adult females Open

Linda Brubaker, Daniel McDonald, S. Putnam, Caitriona Brennan, Cynthia S. Fok , et al. · 2025

Despite the established association with lower urinary tract symptoms, the relationship between a healthy bladder and the urogenital microbiome is unknown. This observational cohort study of 435 community-dwelling women examined bladder he…

Redundant and Singular Regulatory Elements Underlie the Rapidly Evolving Pigmentation of <i>Drosophila</i> Open

Linda Brubaker, Hongan Long, Allison Pavlus, Melissa Williams, Devon M Seibert , et al. · 2025

A major hurdle in understanding the molecular changes responsible for metazoan diversity is the characterization of cis-regulatory elements (CREs) for gene regulatory networks (GRNs). CRE changes are suspected to be commonplace in trait ev…

Polymicrobial urine cultures: reconciling contamination with the urobiome while recognizing the pathogens Open

Robert B. Moreland, Linda Brubaker, Alan J. Wolfe · 2025

Polymicrobial or mixed urine cultures of more than one predominant microbe confound clinical urinary tract infection diagnosis. The current College of American Pathologists clinical laboratory standard states that a urine sample cultured w…

Correction for Moreland et al., “Rapid and accurate testing for urinary tract infection: new clothes for the emperor” Open

Robert B. Moreland, Linda Brubaker, Lana Tinawi, Alan J. Wolfe · 2025

Phage Therapy for Urinary Tract Infections: Progress and Challenges Ahead Open

Chase J. Morgan, Haley Atkins, Alan J. Wolfe, Linda Brubaker, Saima Aslam , et al. · 2025

Introduction and Hypothesis Urinary tract infection (UTI) treatment is a growing public health concern owing to increasing antimicrobial resistance. Phage therapy, an alternative or adjunctive treatment to antibiotics, has the potential to…

22P Characterizing the cancer spectrum of germline SMARCA4 variants to estimate penetrance Open

Michaël Chandler, X. Zhang, Sue E. Crawford, Linda Brubaker, Rebecca Sisson , et al. · 2025

Urinary Metabolomic Profile is Minimally Impacted by Common Storage Conditions and Additives Open

Kelly C. Weldon, Morgan Panitchpakdi, Andrés Mauricio Caraballo‐Rodríguez, Alan J. Wolfe, Pieter C. Dorrestein , et al. · 2025

Polymicrobial Urine Cultures: Reconciling Contamination with the Urobiome while Recognizing the Pathogens Open

Robert B. Moreland, Linda Brubaker, Alan J. Wolfe · 2025

Polymicrobial or mixed urine cultures of more than one predominant microbe confound clinical urinary tract infection diagnosis. The current College of American Pathologists clinical laboratory standard states that a urine sample cultured w…

Ethnic and racial social identity, socioeconomic position, and women's bladder health Open

Sonya S. Brady, Heather Klusaritz, Chloe Falke, Sheila Gahagan, Jeni Hebert‐Beirne , et al. · 2025

241 - BLADDER HEALTH IN WOMEN: POPULATION-BASED ESTIMATES FROM THE US-BASED RISE FOR HEALTH STUDY Open

Siobhan Sutcliffe, Conner Falke, Kyle Rudser, Gerald McGwin, Sonya S. Brady , et al. · 2024

Harnessing the power within: engineering the microbiome for enhanced gynecologic health Open

Caitriona Brennan, Kristina Chan, Tanya Kumar, Erica S. Maissy, Linda Brubaker , et al. · 2024

Graphical abstract Abstract Although numerous studies have demonstrated the impact of microbiome manipulation on human health, research on the microbiome’s influence on female health remains relatively limited despite substantial disease b…

Urinary Metabolomic Profile is Minimally Impacted by Common Storage Conditions and Additives Open

Kelly C. Weldon, Morgan Panitchpakdi, Andrés Mauricio Caraballo‐Rodríguez, Alan J. Wolfe, Pieter C. Dorrestein , et al. · 2024

Metabolomics reflects the molecular communications within a biological system. Urine can be obtained non-invasively and is rich in metabolites that are potential biomarkers for human health and disease. The optimal urine storage conditions…

Association Between Maternal Depression and Lower Urinary Tract Symptoms in Their Primary School-Age Daughters Open

Shayna D. Cunningham, Sarah Lindberg, Carol Joinson, David A. Shoham, Haitao Chu , et al. · 2024

PURPOSE: Although maternal depression is associated with adverse outcomes in women and children, its relationship with lower urinary tract symptoms (LUTS) in offspring is less well-characterized. We examined the association between prenata…

Effects of variation in sample storage conditions and swab order on 16S vaginal microbiome analyses Open

Tanya Kumar, MacKenzie Bryant, Kalen Cantrell, Se Jin Song, Daniel McDonald , et al. · 2023

Technical bias is a pressing issue in microbiome research, and variability can be introduced at any stage from sample collection to figure generation. In this study, we aim to reduce biases in studying the human vaginal microbiome by exami…

The brain, gut, and bladder health nexus: A conceptual model linking stress and mental health disorders to overactive bladder in women Open

Ariana L. Smith, Amanda Berry, Linda Brubaker, Shayna D. Cunningham, Sheila Gahagan , et al. · 2023

Objective A small, but growing literature links stressors and mental health disorders (MHDs) across the life course to overactive bladder (OAB) and urinary incontinence symptoms. Mechanisms by which stressors and MHDs may impact bladder he…

Urinary microbiome community types associated with urinary incontinence severity in women Open

Megan Ulmer Carnes, Nazema Y. Siddiqui, Lisa Karstens, Marie G. Gantz, Darrell L. Dinwiddie , et al. · 2023

790P Uniform prospective molecular analysis of endometrial carcinoma: Feasibility, outcomes, and effect on management Open

Bradley R. Corr, Junxiao Hu, Christine Walsh, Jill Alldredge, Linda Brubaker , et al. · 2023

JAMA Open