Les P. Miranda
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View article: RELATO DE CASO: HISTOPLASMOSE DISSEMINADA E PANCITOPENIA EM PACIENTE COM SÍNDROME DA IMUNODEfiCIÊNCIA ADQUIRIDA (AIDS)
RELATO DE CASO: HISTOPLASMOSE DISSEMINADA E PANCITOPENIA EM PACIENTE COM SÍNDROME DA IMUNODEfiCIÊNCIA ADQUIRIDA (AIDS) Open
View article: DESAFIOS NO MANEJO DE ANEMIA FERROPRIVA GRAVE EM PACIENTES IDOSOS: RELATO DE CASO
DESAFIOS NO MANEJO DE ANEMIA FERROPRIVA GRAVE EM PACIENTES IDOSOS: RELATO DE CASO Open
Introdução/Objetivo: A anemia ferropriva causada pela deficiência de ferro, é a carência nutricional mais prevalente na saúde pública. Essa doença atinge todas as classes sociais, com maior evidência em crianças e mulheres, podendo atingir…
View article: HERANÇA GENÉTICA PARA PACIENTE COM BETA-TALASSEMIA E TRAÇO FALCIFORME: RELATO DE CASO
HERANÇA GENÉTICA PARA PACIENTE COM BETA-TALASSEMIA E TRAÇO FALCIFORME: RELATO DE CASO Open
Objetivo: Descrever um caso de interação entre a hemoglobinopatia Hb S e a β-talassemia minor. Relato de caso: Trata-se de um paciente masculino, de 9 anos, em acompanhamento no ambulatório de hematologia pediátrica do Hospital Universitár…
View article: Biotechnology and Bioengineering: Volume 121, Number 4, April 2024
Biotechnology and Bioengineering: Volume 121, Number 4, April 2024 Open
View article: Accelerating Attribute-Focused Process and Product Development Through the Development and Deployment of Autonomous Process Analytical Technology Platform System
Accelerating Attribute-Focused Process and Product Development Through the Development and Deployment of Autonomous Process Analytical Technology Platform System Open
Enabling real-time monitoring and control of the biomanufacturing processes through product quality insights continues to be an area of focus in the biopharmaceutical industry. The goal is to manufacture products with the desired quality a…
View article: Process development of a SARS-CoV-2 nanoparticle vaccine
Process development of a SARS-CoV-2 nanoparticle vaccine Open
View article: Development of human-machine language interfaces for the visual analysis of complex biologics and RNA modalities and associated experimental data
Development of human-machine language interfaces for the visual analysis of complex biologics and RNA modalities and associated experimental data Open
The advent of recombinant protein-based therapeutic agents in the 1980s and subsequent waves of innovation in molecular biology and engineering of biologics has permitted the production of an increasingly broad array of complex, high molec…
View article: Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model Open
Inhibition of the pituitary adenylate cyclase 1 receptor (PAC1R) is a novel mechanism that could be used for abortive treatment of acute migraine. Our research began with comparative analysis of known PAC1R ligand scaffolds, PACAP38 and Ma…
View article: Structure-guided discovery of dual recognition chemibodies
Structure-guided discovery of dual recognition chemibodies Open
Small molecules and antibodies each have advantages and limitations as therapeutics. Here, we present for the first time to our knowledge, the structure-guided design of as small molecule-antibody hybrids that offer dual recognition of a …
View article: Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring
Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring Open
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for p…
View article: Discovery of Tarantula Venom-Derived Na<sub>V</sub>1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis
Discovery of Tarantula Venom-Derived Na<sub>V</sub>1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis Open
Inhibitors of the voltage-gated sodium channel NaV1.7 are being investigated as pain therapeutics due to compelling human genetics. We previously identified NaV1.7-inhibitory peptides GpTx-1 and JzTx-V from tarantula …
View article: Structure-guided Discovery of Dual-recognition Chemibodies
Structure-guided Discovery of Dual-recognition Chemibodies Open
View article: Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V
Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V Open
Identification of voltage-gated sodium channel NaV1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent leads compared to our previously reported GpTx-1 peptide series,…
View article: Fulguraciones Solares de los Primeros Dias de Septiembre 2017 Registrados Por el Observatorio Geomagnetico de Villa Remedios Y El Monitor de Neutrones Nm-64 de Chacaltaya Cotejados con Registros de Flujo de Rayos X Solares del Satelite GOES
Fulguraciones Solares de los Primeros Dias de Septiembre 2017 Registrados Por el Observatorio Geomagnetico de Villa Remedios Y El Monitor de Neutrones Nm-64 de Chacaltaya Cotejados con Registros de Flujo de Rayos X Solares del Satelite GOES Open
November (19 to 24), 2017, sixty three geomagneticists and students from all three Americas, Europe and Africa attended the II Pan American Workshop on Geomagnetism (II PANGEO) in Vassouras, Rio de Janeiro State, Brazil.II PANGEO consisted…
View article: Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction
Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction Open
The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes. Inflammatory disorders and malignancies are often associated with high …
View article: Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the Na<sub>V</sub>1.7 Inhibitory Peptide GpTx-1
Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the Na<sub>V</sub>1.7 Inhibitory Peptide GpTx-1 Open
There is interest in the identification and optimization of new molecular entities selectively targeting ion channels of therapeutic relevance. Peptide toxins represent a rich source of pharmacology for ion channels, and we recently report…
View article: A Potent <scp>d</scp>-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating <i>in Vivo</i>
A Potent <span>d</span>-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating <i>in Vivo</i> Open
Polypeptides composed entirely of d-amino acids and the achiral amino acid glycine (d-proteins) inherently have in vivo properties that are proposed to be near-optimal for a large molecule therapeutic agent. Specifically, d-proteins are re…
View article: Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3
Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3 Open
To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides, as ion channel antagonists, more efficient pharmaceutical optimization technologies must be developed. Here, we show that the therapeutic pr…
View article: Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the Na<sub>V</sub>1.7 Sodium Channel
Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the Na<sub>V</sub>1.7 Sodium Channel Open
NaV1.7 is a voltage-gated sodium ion channel implicated by human genetic evidence as a therapeutic target for the treatment of pain. Screening fractionated venom from the tarantula Grammostola porteri led to the identification of a 34-resi…