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View article: Publisher Correction: Academia Europaea’s guidelines for the visualization of clinical outcomes
Publisher Correction: Academia Europaea’s guidelines for the visualization of clinical outcomes Open
View article: Betulinic Acid Self‐Assembled Nanodelivery System Attenuates Osteoarthritis by Dually Modulating Macrophage Polarization and Macrophage‐Chondrocyte Crosstalk via Disruption of the GSK3β/NF‐κB/CCL20 Axis
Betulinic Acid Self‐Assembled Nanodelivery System Attenuates Osteoarthritis by Dually Modulating Macrophage Polarization and Macrophage‐Chondrocyte Crosstalk via Disruption of the GSK3β/NF‐κB/CCL20 Axis Open
Osteoarthritis (OA) is a degenerative joint disease characterized by M1 macrophage‐driven synovitis, worsening progression. In this study, it is found that betulinic acid (BA), a natural compound, inhibits M1 macrophage characteristics whi…
View article: General anaesthetics reduce acute lymphoblastic leukaemia malignancies in vitro and in vivo via CXCR4 and osteopontin mediated mechanisms
General anaesthetics reduce acute lymphoblastic leukaemia malignancies in vitro and in vivo via CXCR4 and osteopontin mediated mechanisms Open
Background Acute lymphoblastic leukaemia (ALL) is a common type of cancer in children. General anaesthetics are often used on patients undergoing painful procedures during ALL treatments but their effects on ALL malignancy remain unknown. …
View article: MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity
MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity Open
View article: Development of LYTACs via incorporating a nucleolin-targeting and lysosome-directed aptamer
Development of LYTACs via incorporating a nucleolin-targeting and lysosome-directed aptamer Open
Lysosomal targeting chimeras (LYTACs) represent an emerging class of bifunctional molecules that bridge extracellular target proteins with intrinsic lysosome-targeting receptors (LTRs) on the cell surface, facilitating endocytic internaliz…
View article: GRAPE: graph-regularized protein language modeling unlocks TCR-epitope binding specificity
GRAPE: graph-regularized protein language modeling unlocks TCR-epitope binding specificity Open
T-cell receptor (TCR)-epitope binding prediction is critical for immunotherapies but remains challenged by sparse interaction networks and severe class imbalance in training data. Current graph neural network (GNN) approaches for predictin…
View article: Transcriptome analysis revealed the mechanism of exogenous silicon alleviating allelopathic inhibition of cinnamic acid on soybean seedlings
Transcriptome analysis revealed the mechanism of exogenous silicon alleviating allelopathic inhibition of cinnamic acid on soybean seedlings Open
Background Soybean (Glycine max (Linn.) Merr.) is one of the important grain crops in China and a significant oilseed and high-protein dual-purpose crop both in China and worldwide. During soybean cultivation, continuous cropping obstacles…
View article: WITHDRAWN: Anti-Hepatocellular Carcinoma effect of Pien-Tze-Huang via multi-target regulation of PI3K/Akt Pathway inducing cell cycle arrest: from computational prediction to experimental validation
WITHDRAWN: Anti-Hepatocellular Carcinoma effect of Pien-Tze-Huang via multi-target regulation of PI3K/Akt Pathway inducing cell cycle arrest: from computational prediction to experimental validation Open
View article: Targeting nucleolin facilitates the development of blood-tumor barrier-penetrating and glioblastoma-specific PROTACs
Targeting nucleolin facilitates the development of blood-tumor barrier-penetrating and glioblastoma-specific PROTACs Open
Targeted therapy for glioblastoma (GBM) is challenged by the blood-tumor barrier (BTB). Extracellular vesicles (EVs) from GBM cells play a role in transforming BBB into BTB, although the mechanisms are not fully understood. This study iden…
View article: ABA-GA antagonism and modular gene networks cooperatively drive acquisition of desiccation tolerance in perilla seeds
ABA-GA antagonism and modular gene networks cooperatively drive acquisition of desiccation tolerance in perilla seeds Open
Introduction Perilla ( Perilla frutescens (L.) Britt.), a valuable source of omega-3 oils and bioactive compounds in Asia, exhibits poor seed storage and germination performance. Understanding the genetic basis of desiccation tolerance (DT…
View article: An Interpretable AI framework Quantifying Traditional Chinese Medicine Principles Towards Enhancing and Integrating with Modern Biomedicine
An Interpretable AI framework Quantifying Traditional Chinese Medicine Principles Towards Enhancing and Integrating with Modern Biomedicine Open
Traditional Chinese Medicine diagnosis and treatment principles, established through centuries of trial-and-error clinical practice, directly maps patient-specific symptom patterns to personalised herbal therapies. These empirical holistic…
View article: Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis Open
View article: Reinforced immunotherapy of M1 macrophage-derived exosomes with CEL on TNBC via regulating macrophage functions
Reinforced immunotherapy of M1 macrophage-derived exosomes with CEL on TNBC via regulating macrophage functions Open
Our study showed a reinforced immunotherapy that the synthesized tLyP-1-M1-Exos/CEL could not only reverse M2 macrophages into M1 to reshape immunosuppressive TME but also decrease the expression of MHC Ⅰ on tumor surface to enhance macrop…
View article: Author Correction: Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Author Correction: Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation Open
View article: Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis
Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis Open
Chondrocyte senescence, synovitis, and decreased level of lubrication play pivotal roles in the pathogenesis of age-related osteoarthritis (AROA). However, there are currently no effective therapeutic interventions capable of altering the …
View article: Explore the Application Value of Metagenomic Next-Generation Sequencing of Bronchoalveolar Lavage Fluid in the Early Diagnosis of Pulmonary Tuberculosis
Explore the Application Value of Metagenomic Next-Generation Sequencing of Bronchoalveolar Lavage Fluid in the Early Diagnosis of Pulmonary Tuberculosis Open
BALF mNGS demonstrates high sensitivity and accuracy for PTB diagnosis, outperforming conventional sputum-based methods. Although BALF TB-DNA achieved the highest specificity and NPV, BALF mNGS serves as a robust supplementary tool, partic…
View article: Classifications of triple-negative breast cancer: insights and current therapeutic approaches
Classifications of triple-negative breast cancer: insights and current therapeutic approaches Open
View article: Elevating traditional Chinese medicine in global health research: The case for Chinese herbal medicine formulas in mainstream therapeutics
Elevating traditional Chinese medicine in global health research: The case for Chinese herbal medicine formulas in mainstream therapeutics Open
View article: Pristimerin Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proliferation
Pristimerin Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proliferation Open
Triple‐negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis. The natural compound pristimerin has shown promising anti‐tumor effect. Here, it is found that pristimerin significantly triggered the activation of …
View article: Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer
Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer Open
Alpha-1 antitrypsin (AAT) is a key serine protease inhibitor for regulating proteases such as neutrophil elastase. AAT restrains the pulmonary matrix from enzymatic degradation, and a deficiency in AAT leads to inflammatory tissue damage i…
View article: Leveraging artificial intelligence and machine learning for unraveling pathogenesis and advancing precision medicine in autoimmune diseases
Leveraging artificial intelligence and machine learning for unraveling pathogenesis and advancing precision medicine in autoimmune diseases Open
Autoimmune diseases (AIDs) are intricate disorders in which the immune system mistakenly attacks the body’s own tissues. Recent advancements in omics technologies, as well as artificial intelligence (AI) and machine learning (ML), have sig…
View article: Unveiling the Therapeutic Potential: Targeting Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Unveiling the Therapeutic Potential: Targeting Fibroblast-like Synoviocytes in Rheumatoid Arthritis Open
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the synovial membrane, leading to cartilage destruction and bone erosion. Due to the complex pathogenesis of RA and the limitations of curr…
View article: DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model
DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model Open
View article: Insights and therapeutic advances in pancreatic cancer: the role of electron microscopy in decoding the tumor microenvironment
Insights and therapeutic advances in pancreatic cancer: the role of electron microscopy in decoding the tumor microenvironment Open
Pancreatic cancer is one of the most lethal cancers, with a 5-year overall survival rate of less than 10%. Despite the development of novel therapies in recent decades, current chemotherapeutic strategies offer limited clinical benefits du…
View article: Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma
Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma Open
Rationale: Osteosarcoma (OS) is the most common bone malignancy. c-MET is recognized as a therapeutic target. However, traditional c-MET inhibitors show compromised efficacy due to the acquired resistance and side effects. PROTACs t…
View article: Critical radicle length window governing loss of dehydration tolerance in germinated Perilla seeds: insights from physiological and transcriptomic analyses
Critical radicle length window governing loss of dehydration tolerance in germinated Perilla seeds: insights from physiological and transcriptomic analyses Open
View article: Inflammatory Processes: Key Mediators of Oncogenesis and Progression in Pancreatic Ductal Adenocarcinoma (PDAC)
Inflammatory Processes: Key Mediators of Oncogenesis and Progression in Pancreatic Ductal Adenocarcinoma (PDAC) Open
Associations between inflammation and cancer were first discovered approximately 160 years ago by Rudolf Virchow, who observed that tumors were infiltrated with inflammatory cells, and defined inflammation as a pathological condition. Infl…
View article: Erratum to “CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis” [Pharmacol. Res. 207 (2024) 107346]
Erratum to “CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis” [Pharmacol. Res. 207 (2024) 107346] Open
View article: SMTRI: A deep learning-based web service for predicting small molecules that target miRNA-mRNA interactions
SMTRI: A deep learning-based web service for predicting small molecules that target miRNA-mRNA interactions Open
Mature microRNAs (miRNAs) are short, single-stranded RNAs that bind to target mRNAs and induce translational repression and gene silencing. Many miRNAs discovered in animals have been implicated in diseases and have recently been pursued a…
View article: CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis
CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis Open
Synovitis is characterized by a distinctmetabolic profile featuring the accumulation of lactate, a byproduct of cellular metabolism within inflamed joints. This study reveals that the activation of the CD31 signal by lactate instigates a m…