Lu Ke
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View article: Nationwide expert survey on transfusion and coagulation management strategies for bleeding critically ill patients in China
Nationwide expert survey on transfusion and coagulation management strategies for bleeding critically ill patients in China Open
This study aimed to investigate coagulation management strategies by experienced critical care physicians across China. The questionnaire was independently designed referencing current guidelines and literature, and refined through five ro…
View article: Fusion of numerical simulation and on-site monitoring for full-life-cycle stability regulation and reinforcement optimization of karst region large-span aqueduct slopes: a case study of the Longchang Aqueduct in the Qianzhong Water Hub, China
Fusion of numerical simulation and on-site monitoring for full-life-cycle stability regulation and reinforcement optimization of karst region large-span aqueduct slopes: a case study of the Longchang Aqueduct in the Qianzhong Water Hub, China Open
This study establishes a full-lifecycle stability control framework for ultra-large-span aqueduct slopes in karst terrain, integrating numerical simulation and field monitoring. Using the Longchang Aqueduct slope of Guizhou’s Qianzhong Wat…
View article: Blood urea nitrogen to albumin ratio as a robust predictor of in-hospital mortality in patients with predicted severe acute pancreatitis: a retrospective multicenter observational study
Blood urea nitrogen to albumin ratio as a robust predictor of in-hospital mortality in patients with predicted severe acute pancreatitis: a retrospective multicenter observational study Open
Background: Despite the established role of blood urea nitrogen-to-albumin ratio (BAR) in critical care, its prognostic value in acute pancreatitis remains unvalidated. This multicenter study assessed BAR’s accuracy as an admission biomark…
View article: Early energy delivery and 28-day mortality in critically ill patients with sepsis: Post hoc analysis of a multicenter cluster-randomised controlled trial
Early energy delivery and 28-day mortality in critically ill patients with sepsis: Post hoc analysis of a multicenter cluster-randomised controlled trial Open
ISRCTN 12233792, registered on November 24, 2017.
View article: The short-term and long-term clinical outcomes from early versus delayed minimally invasive intervention for acute necrotic collections in necrotizing pancreatitis: a systematic review and meta-analysis
The short-term and long-term clinical outcomes from early versus delayed minimally invasive intervention for acute necrotic collections in necrotizing pancreatitis: a systematic review and meta-analysis Open
Introduction: Evidence regarding the optimal timing of intervention for symptomatic acute necrotic collections (ANCs) in necrotizing pancreatitis remains inconsistent, particularly in the era of minimally invasive step-up approaches. This …
View article: Membrane proteomics and transcriptomic profiling analysis of hepatic stellate cells co-incubated with Schistosoma japonicum eggs
Membrane proteomics and transcriptomic profiling analysis of hepatic stellate cells co-incubated with Schistosoma japonicum eggs Open
Schistosomiasis has been recognized as the second most prevalent parasitic disease worldwide, following malaria. Schistosome eggs can persist for extended periods within host hepatic tissues, leading to hepatic fibrosis primarily through t…
View article: Praziquantel Pretreatment Reduces Schistosoma japonicum Infection in Mice by Targeting Immature Worm Stages
Praziquantel Pretreatment Reduces Schistosoma japonicum Infection in Mice by Targeting Immature Worm Stages Open
Schistosomiasis remains a significant public health concern, with Schistosoma japonicum infection endemic in certain regions of Asia. Praziquantel (PZQ), primarily known as an effective therapeutic agent, has recently shown potential as a …
View article: SpiroSense: Transforming Smartphones into Pulmonary Metrics Monitors with Ultrasonic Technology
SpiroSense: Transforming Smartphones into Pulmonary Metrics Monitors with Ultrasonic Technology Open
Chronic respiratory conditions such as Chronic Obstructive Pulmonary Disease (COPD) and asthma often progress insidiously, making early detection vital for effective intervention. Current gold-standard Pulmonary Function Testing (PFT) meth…
View article: Association between creatinine clearance and mortality in Chinese patients with osteoporotic fractures: a retrospective cohort study
Association between creatinine clearance and mortality in Chinese patients with osteoporotic fractures: a retrospective cohort study Open
Background Creatinine clearance (CCR) is a vital biomarker for evaluating renal function, indicating the efficiency of the kidneys in filtering blood waste. However, the link between CCR and mortality in hospitalized patients with osteopor…
View article: Efficacy and safety of heart rate control with esmolol on the incidence and duration of organ failure in predicted severe acute pancreatitis: protocol of a multicenter, open-label, randomized controlled trial
Efficacy and safety of heart rate control with esmolol on the incidence and duration of organ failure in predicted severe acute pancreatitis: protocol of a multicenter, open-label, randomized controlled trial Open
Introduction Overactivation of the sympathetic nerve system can lead to a sustained increase in heart rate, which may impair blood perfusion and organ function. Previous studies have demonstrated that the use of β -blockers like esmolol ca…
View article: Semi-elemental versus polymeric formula for enteral nutrition in critically ill patients: a secondary analysis of a multicenter cluster-randomized controlled trial
Semi-elemental versus polymeric formula for enteral nutrition in critically ill patients: a secondary analysis of a multicenter cluster-randomized controlled trial Open
Objectives Semi-elemental enteral nutrition (EN) might theoretically improve gastrointestinal tolerance in critically ill patients; however, it is associated with an increased risk of diarrhea when delivered postpylorically. This study aim…
View article: Efficacy and safety of intensive triglyceride-lowering therapy on reducing recurrence of hypertriglyceridemia-associated pancreatitis (REDUCE): protocol for a multicentre, randomised controlled trial
Efficacy and safety of intensive triglyceride-lowering therapy on reducing recurrence of hypertriglyceridemia-associated pancreatitis (REDUCE): protocol for a multicentre, randomised controlled trial Open
Introduction Recurrence of hypertriglyceridaemia-associated acute pancreatitis (HTG-AP) is common. Uncontrolled HTG after hospital discharge is an important risk factor for recurrence. However, the optimal triglyceride (TG) goal of lipid-l…
View article: Triglyceride lowering in patients with different severities of hypertriglyceridaemia-associated acute pancreatitis: secondary analysis of a multicentre, prospective cohort study
Triglyceride lowering in patients with different severities of hypertriglyceridaemia-associated acute pancreatitis: secondary analysis of a multicentre, prospective cohort study Open
Objective It is controversial whether rapid lowering of triglyceride (TG) levels is associated with clinical benefits in patients with hypertriglyceridaemia-associated acute pancreatitis (HTG-AP). In particular, patients with different sev…
View article: Effect of Praziquantel on Preventing Delayed Infection of Schistosoma japonicum in Buffaloes and Goats
Effect of Praziquantel on Preventing Delayed Infection of Schistosoma japonicum in Buffaloes and Goats Open
Schistosomiasis, caused by Schistosoma japonicum, continues to pose a major public health threat in East Asia, with an estimated 71 million people at risk of infection. Domestic animals, especially buffaloes and goats, serve as important r…
View article: Triglyceride-lowering therapies in hypertriglyceridemia-associated acute pancreatitis in China: a multicentre prospective cohort study
Triglyceride-lowering therapies in hypertriglyceridemia-associated acute pancreatitis in China: a multicentre prospective cohort study Open
Triglyceride-lowering therapies vary greatly across centres. More rapid triglyceride decline was not associated with improving incidence and duration of organ failure.
View article: Trehalose ameliorates severe acute pancreatitis by modulating the gut microbial metabolism
Trehalose ameliorates severe acute pancreatitis by modulating the gut microbial metabolism Open
Severe Acute Pancreatitis (SAP) is an acute, severe, and high-mortality special type of pancreatitis, often accompanied by gut microbiota disorders. Gut microbiota and its derived metabolites are involved in SAP progression, but gut microb…
View article: Traditional Chinese medicine to improve immune imbalance of asthma: focus on the adjustment of gut microbiota
Traditional Chinese medicine to improve immune imbalance of asthma: focus on the adjustment of gut microbiota Open
Asthma, being the prevailing respiratory ailment globally, remains enigmatic in terms of its pathogenesis. In recent times, the advancement of traditional Chinese medicine pertaining to the intestinal microbiota has yielded a plethora of i…
View article: A dual-radiomics model for overall survival prediction in early-stage NSCLC patient using pre-treatment CT images
A dual-radiomics model for overall survival prediction in early-stage NSCLC patient using pre-treatment CT images Open
Introduction Radiation therapy (RT) is one of the primary treatment options for early-stage non-small cell lung cancer (ES-NSCLC). Therefore, accurately predicting the overall survival (OS) rate following radiotherapy is crucial for implem…
View article: Metagenomic Next-Generation Sequencing-Based Fine-Needle Aspiration in Patients With Suspected Infected Pancreatic Necrosis
Metagenomic Next-Generation Sequencing-Based Fine-Needle Aspiration in Patients With Suspected Infected Pancreatic Necrosis Open
INTRODUCTION: Fine-needle aspiration (FNA) is no longer recommended for diagnosing infected pancreatic necrosis (IPN) due to a high false-negative rate. Metagenomic next-generation sequencing (mNGS) is a valuable tool for identifying poten…
View article: Traditional and Non-Traditional Lipid Parameters in Relation to Parenchymal Hemorrhage Following Endovascular Treatment for Acute Ischemic Stroke in Anterior Circulation
Traditional and Non-Traditional Lipid Parameters in Relation to Parenchymal Hemorrhage Following Endovascular Treatment for Acute Ischemic Stroke in Anterior Circulation Open
In assessing the risk of PH after EVT, non-traditional lipid parameters are often superior to traditional lipid parameters. It is recommended that routine evaluation of non-traditional lipid parameters could also be conducted in clinical p…
View article: Early prediction and prevention of infected pancreatic necrosis
Early prediction and prevention of infected pancreatic necrosis Open
Approximately 20%-30% of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis (IPN), a highly morbid and potentially lethal complication. Early identification of patients at high risk of IPN may facilitate appr…
View article: Immune-Enhancing Treatment among Acute Necrotizing Pancreatitis Patients with Metabolic Abnormalities: A <i>Post Hoc</i> Analysis of a Randomized Clinical Trial
Immune-Enhancing Treatment among Acute Necrotizing Pancreatitis Patients with Metabolic Abnormalities: A <i>Post Hoc</i> Analysis of a Randomized Clinical Trial Open
Among ANP patients with hyperglycemia, immune-enhancing Tα1 treatment was associated with a reduced risk of IPN (ClinicalTrials.gov, Registry number: NCT02473406).