Lei Zhang
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View article: Impact of Intraoperative Ultrasound-Guided Loop Electrosurgical Excision Procedure With Individualized Marking on Perioperative Stress Responses, Immune Parameters, and Clinical Outcomes: A Comparative Study With Conventional Surgery
Impact of Intraoperative Ultrasound-Guided Loop Electrosurgical Excision Procedure With Individualized Marking on Perioperative Stress Responses, Immune Parameters, and Clinical Outcomes: A Comparative Study With Conventional Surgery Open
AIM: This study compared the standard loop electrosurgical excision procedure (LEEP) with an enhanced technique incorporating intraoperative ultrasound guidance and individualized marking for high-risk human papillomavirus (HPV)-associated…
View article: Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development
Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development Open
Essential thrombocythemia (ET) includes the JAK2 ‐, CALR ‐, and MPL ‐mutated subtypes, and a triple‐negative (TN) ET subtype, which lacks these canonical drivers. How specific driver mutations affect hematopoietic stem cell (HSC) heterogen…
View article: Factor IX-Padua AAV gene therapy in hemophilia B: phases 1/2 and 3 trials
Factor IX-Padua AAV gene therapy in hemophilia B: phases 1/2 and 3 trials Open
Gene therapy for hemophilia B with adeno-associated virus (AAV) vector has achieved great advances over the last decade. We previously conducted a pilot study demonstrating the safety and efficacy of AAV-factor IX (FIX) Padua gene therapy …
View article: Metabolic characteristics related to potentially toxic elements in the blood of young adults in China: a cross-sectional study
Metabolic characteristics related to potentially toxic elements in the blood of young adults in China: a cross-sectional study Open
Epidemiological evidence links essential and potentially toxic metals exposure to impaired lung function, but underlying biological mechanisms remain unclear. Building on previous findings demonstrating impaired lung function from copper (…
View article: Comparative efficacy of decontamination methods for laparoscopic equipment: a systematic review and meta-analysis
Comparative efficacy of decontamination methods for laparoscopic equipment: a systematic review and meta-analysis Open
Objective To compare the effectiveness of manual cleaning, alkaline multi-enzyme immersion with ultrasonic cleaning, and automatic reprocessing machines in decontaminating laparoscopes through a systematic review and meta-analysis of rando…
View article: Real-world clinical trial of hetrombopag (TPO-RA) in the treatment of primary immune thrombocytopenia (ITP)
Real-world clinical trial of hetrombopag (TPO-RA) in the treatment of primary immune thrombocytopenia (ITP) Open
Background: Primary immune Thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disorder characterized by isolated peripheral thrombocytopenia without identifiable causes. Its primary pathogenesis involves increased platelet destru…
View article: Long-term outcomes with emicizumab prophylaxis in patients with hemophilia a in China
Long-term outcomes with emicizumab prophylaxis in patients with hemophilia a in China Open
Introduction: Emicizumab, a bispecific monoclonal antibody that bridges activated factor IX and factor X, has emerged as an effective prophylactic treatment for patients with hemophilia A (PwHAs). However, real-world responses are heteroge…
View article: Improved health-related quality of life (HRQoL) and bleeding scores with oral bruton tyrosine kinase (BTK) inhibitor rilzabrutinib in the open-label (OL) period of the multicenter Phase 3 LUNA3 study in adults with immune thrombocytopenia (ITP)
Improved health-related quality of life (HRQoL) and bleeding scores with oral bruton tyrosine kinase (BTK) inhibitor rilzabrutinib in the open-label (OL) period of the multicenter Phase 3 LUNA3 study in adults with immune thrombocytopenia (ITP) Open
Introduction Rilzabrutinib, a BTK inhibitor that acts through multi-immune modulation, showed rapid and durable platelet response, reduced bleeding, significantly improved physical fatigue, and a well-tolerated safety profile in the double…
View article: Chinese guidance for the clinical application of adeno-associated virus vector-based gene therapy for hemophilia B (2025)
Chinese guidance for the clinical application of adeno-associated virus vector-based gene therapy for hemophilia B (2025) Open
Currently, factor IX replacement is the mainstay treatment for hemophilia B in clinical practice. However, since the disease cannot be cured, lifelong treatment and frequent infusion is required. In recent years, hemophilia B gene therapy …
View article: Anti-CD38 monoclonal antibody CM313 for primary immune thrombocytopenia: multicentre, randomised, placebo controlled, phase 2 trial
Anti-CD38 monoclonal antibody CM313 for primary immune thrombocytopenia: multicentre, randomised, placebo controlled, phase 2 trial Open
Objective To assess the efficacy and safety of CM313, an anti-CD38 monoclonal antibody, in adults with persistent or chronic primary immune thrombocytopenia. Design Multicentre, randomised, placebo controlled, phase 2 trial. Setting Five h…
View article: Spatial–Temporal Patterns of Methane Emissions from Livestock in Xinjiang During 2000–2020
Spatial–Temporal Patterns of Methane Emissions from Livestock in Xinjiang During 2000–2020 Open
Livestock represent a significant source of methane (CH4) emissions, particularly in pastoral regions. However, in Xinjiang—a pivotal pastoral region of China—the spatiotemporal patterns of livestock CH4 emissions remain poorly characteriz…
View article: Kimura Disease: Retrospective Analysis of 53 Cases and Three Mepolizumab-Responsive Cases
Kimura Disease: Retrospective Analysis of 53 Cases and Three Mepolizumab-Responsive Cases Open
This study provided a comprehensive summary and age-stratified analysis of the clinical characteristics of KD, providing valuable insights into its pathophysiology and potential overlapping mechanisms. Additionally, the study presents clin…
View article: Unveiling the dynamics and therapeutic potential of m<sup>6</sup>A methyltransferases and demethylases in liver diseases
Unveiling the dynamics and therapeutic potential of m<sup>6</sup>A methyltransferases and demethylases in liver diseases Open
N6-methyladenosine (m6A), a well-known adenosine modification with newly recognized epigenetic functions, reportedly participates in the development of diverse liver diseases. Methyltransferases and demethylases, commonly referred to as "w…
View article: Bridging Pain and Motoric Cognitive Risk Syndrome: Mediating Effect of Handgrip Strength
Bridging Pain and Motoric Cognitive Risk Syndrome: Mediating Effect of Handgrip Strength Open
The study found that pain is positively associated with MCR, while HGS is negatively associated with MCR, and HGS mediates the relationship between pain and MCR.
View article: Association between the oxidative balance score and gynecologic cancers from the National Health and Nutrition Examination Survey: An observational study
Association between the oxidative balance score and gynecologic cancers from the National Health and Nutrition Examination Survey: An observational study Open
This study aimed to examine the potential correlations between the oxidative balance score (OBS) and gynecological cancers susceptibility. A cross-sectional design was employed, utilizing datasets from the National Health and Nutrition Exa…
View article: Positive rates of Mycoplasma pneumoniae antibodies in children before, during and after COVID-19 outbreak: an observational study in Chengdu, China from 2017 to 2024
Positive rates of Mycoplasma pneumoniae antibodies in children before, during and after COVID-19 outbreak: an observational study in Chengdu, China from 2017 to 2024 Open
Introduction Mycoplasma pneumoniae ( M. pneumoniae ) is a leading pathogen of pediatric pneumonia, yet its epidemiological profile in Chengdu remains understudied. This study aimed to analyze the epidemiological trends of M. pneumoniae ant…
View article: Formulation A in the prevention of rheumatoid arthritis: a study protocol for a multicenter randomized controlled trial
Formulation A in the prevention of rheumatoid arthritis: a study protocol for a multicenter randomized controlled trial Open
Background Interventions to delay or prevent the onset of rheumatoid arthritis (RA) have attracted much attention in recent years. Researchers are now exploring various prevention strategies but no unified consensus was reached. A traditio…
View article: Experimental Study on the Activation Energy of Coal Oxidation Under Different Oxygen Concentrations
Experimental Study on the Activation Energy of Coal Oxidation Under Different Oxygen Concentrations Open
To investigate the effect of oxygen concentration on the activation energy of coal oxidation, low-temperature oxidation experiments were carried out on coal samples under controlled oxygen levels (21%, 12%, 10%, 7%, 5%, and 3%) using a pro…
View article: Investigation on the Reasons for CO Overrun in the Return Air Corner of the Fully Mechanized Coal Mine Working Face
Investigation on the Reasons for CO Overrun in the Return Air Corner of the Fully Mechanized Coal Mine Working Face Open
Abnormal CO gas concentration is one of the common problems in coal mine safety production. In view of the phenomenon of CO overrun in the working face, this paper takes the fully mechanized discharge working face of Zhaoxian Mine as the r…
View article: Pathway to enhancing safety behavior of construction workers through subjective well-being
Pathway to enhancing safety behavior of construction workers through subjective well-being Open
Introduction This study empirically examines the influence of subjective well-being on the safety behavior of construction workers. A theoretical model is constructed based on the relationships among subjective well-being, safety awareness…
View article: Impact of environmental and lifestyle factors on progression and survival in a large Chinese amyotrophic lateral sclerosis cohort
Impact of environmental and lifestyle factors on progression and survival in a large Chinese amyotrophic lateral sclerosis cohort Open
Objective: To investigate the impacts of environmental and lifestyle factors on progression and survival in a large Chinese amyotrophic lateral sclerosis (ALS) cohort. Methods: We investigated a cohort of 1,312 sALS patients prospectively.…
View article: Real defect partial discharge identification method for power cables joints based on integrated PJS-M and GA-SVM algorithm with multi-source fusion
Real defect partial discharge identification method for power cables joints based on integrated PJS-M and GA-SVM algorithm with multi-source fusion Open
Previous studies on 10 kV cable intermediate joint defects have mainly focused on typical defect types and employed single-sensor data acquisition, leading to incomplete characterization of defect features and reduced recognition accuracy.…
View article: Atrial Arrhythmias Related to Antitumor Treatment in Patients with Coronary Heart Disease and Malignant Tumors
Atrial Arrhythmias Related to Antitumor Treatment in Patients with Coronary Heart Disease and Malignant Tumors Open
Aims: This study investigated the occurrence of arrhythmias in patients with malignant tumors and coronary heart disease (CHD) during antitumor drug treatment. Methods: 109 patients with malignant tumors undergoing antitumor treatment at Z…
View article: Dose-optimised recombinant human thrombopoietin versus eltrombopag in patients with immune thrombocytopenia: a multicenter, randomised controlled trial (The TE-ITP Study)
Dose-optimised recombinant human thrombopoietin versus eltrombopag in patients with immune thrombocytopenia: a multicenter, randomised controlled trial (The TE-ITP Study) Open
This trial was supported by grants from the CAMS Innovation Fund for Medical Sciences (CIFMS) (2023-I2M-2-007), Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0500803), National Natural Science Founda…