Miao Lü
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View article: Identification and verification of the key genes involved in gallbladder cancer
Identification and verification of the key genes involved in gallbladder cancer Open
Background Gallbladder cancer (GBC) is a highly aggressive malignancy of the biliary tract. It often lacks distinct symptoms in its early stages, and no specific biomarkers have yet been identified for its diagnosis. Objective To identify …
View article: Clinicopathologic features of allied disorders of Hirschsprung disease and status update
Clinicopathologic features of allied disorders of Hirschsprung disease and status update Open
Allied disorders of Hirschsprung diseases (ADHDs) have abnormal enteric ganglia and symptoms that are similar to congenital megacolon. The classification of ADHDs includes neuronal dysplasia, enteric gangliocytomatosis, isolated ganglion d…
View article: Enhancing the photostability of red fluorescent proteins through FRET with Si-rhodamine for dynamic super-resolution fluorescence imaging
Enhancing the photostability of red fluorescent proteins through FRET with Si-rhodamine for dynamic super-resolution fluorescence imaging Open
By incorporating hybrid FRET pairs with RFPs as energy donors and TMSiR as the acceptor, the intersystem crossing (ISC) of RFPs is suppressed via FRET, leading to enhanced photostability of the RFPs.
View article: The PI3Kδ inhibitor zandelisib on intermittent dosing in relapsed/refractory follicular lymphoma: Results from a global phase 2 study
The PI3Kδ inhibitor zandelisib on intermittent dosing in relapsed/refractory follicular lymphoma: Results from a global phase 2 study Open
In this global phase 2 study in patients with relapsed/refractory follicular lymphoma (FL), zandelisib was administered on intermittent dosing to mitigate immune‐related adverse events and infections that have been reported with oral PI3Kδ…
View article: High performance composite phosphor-in-glass film for laser-driven warm white light on patterned sapphire substrate
High performance composite phosphor-in-glass film for laser-driven warm white light on patterned sapphire substrate Open
Phosphor-in-glass film (PiF) based on sapphire substrate (SS) is a promising laser-driven color converter. Herein, by using an optimized silicon borate glass component, high-performance Y3Al5O12:Ce3+ PiFs are successfully prepared on both …
View article: Diversification in birds is promoted by plant diversity, topographic heterogeneity and stable paleoclimate
Diversification in birds is promoted by plant diversity, topographic heterogeneity and stable paleoclimate Open
Aims Long‐term climate stability, contemporary climate and environmental heterogeneity have been linked to bird diversity patterns through their direct impacts on diversification rate, as well as through their indirect effects on plant spe…
View article: Impacts of Natural Environmental Factors and Anthropogenic Activities on the Distribution of Threatened Orchid Species in China
Impacts of Natural Environmental Factors and Anthropogenic Activities on the Distribution of Threatened Orchid Species in China Open
Natural environmental factors and anthropogenic activities could have strong impacts on threatened species distribution. Based on Random Forest modeling and ordinary least squares models, we tested the correlations between natural environm…
View article: Establishment of a prognostic model for gastric cancer patients who underwent radical gastrectomy using machine learning: a two-center study
Establishment of a prognostic model for gastric cancer patients who underwent radical gastrectomy using machine learning: a two-center study Open
Objective Gastric cancer is a prevalent gastrointestinal malignancy worldwide. In this study, a prognostic model was developed for gastric cancer patients who underwent radical gastrectomy using machine learning, employing advanced computa…
View article: Distributionally Robust Reinforcement Learning with Interactive Data Collection: Fundamental Hardness and Near-Optimal Algorithm
Distributionally Robust Reinforcement Learning with Interactive Data Collection: Fundamental Hardness and Near-Optimal Algorithm Open
The sim-to-real gap, which represents the disparity between training and testing environments, poses a significant challenge in reinforcement learning (RL). A promising approach to addressing this challenge is distributionally robust RL, o…
View article: Safety and efficacy of zandelisib plus zanubrutinib in previously treated follicular and mantle cell lymphomas
Safety and efficacy of zandelisib plus zanubrutinib in previously treated follicular and mantle cell lymphomas Open
Summary The combination of the phosphatidylinositol 3‐kinase delta (PI3Kδ) inhibitor zandelisib with the Bruton's tyrosine kinase (BTK) inhibitor zanubrutinib was hypothesized to be synergistic and prevent resistance to single‐agent therap…
View article: Iterative assembly of $^{171}$Yb atom arrays with cavity-enhanced optical lattices
Iterative assembly of $^{171}$Yb atom arrays with cavity-enhanced optical lattices Open
Assembling and maintaining large arrays of individually addressable atoms is a key requirement for continued scaling of neutral-atom-based quantum computers and simulators. In this work, we demonstrate a new paradigm for assembly of atomic…
View article: Predictive value of machine learning models for lymph node metastasis in gastric cancer: A two-center study
Predictive value of machine learning models for lymph node metastasis in gastric cancer: A two-center study Open
BACKGROUND Gastric cancer is one of the most common malignant tumors in the digestive system, ranking sixth in incidence and fourth in mortality worldwide. Since 42.5% of metastatic lymph nodes in gastric cancer belong to nodule type and p…
View article: Live-Cell Imaging to Resolve Salt-Induced Liquid–Liquid Phase Separation of FUS Protein by Dye Self-Labeling
Live-Cell Imaging to Resolve Salt-Induced Liquid–Liquid Phase Separation of FUS Protein by Dye Self-Labeling Open
The aggregation of fusion in sarcoma (FUS) in the cytoplasm and nucleus is a pathological feature of Amyotrophic lateral sclerosis (ALS) and Frontotemporal Dementia (FTD). Genetic mutations, abnormal protein synthesis, environmental stress…
View article: Figure S1: Effect of treatment protocol on AR gene expression in C4-2 and LAPC4 cells from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Figure S1: Effect of treatment protocol on AR gene expression in C4-2 and LAPC4 cells from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
C4-2 and LAPC4 cells were subjected to treatment protocol (Fig.1A); the canonical AR target genes including KLK3 and NKX3.1 were assessed by real-time PCR analysis. Data from three independent
View article: Table S1: Primer sequence information from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Table S1: Primer sequence information from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
Primers sequence information for qPCR and ChIP-qPCR
View article: Figure S4: Evaluation of AR variant binding to known AREs and Snail promoters from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Figure S4: Evaluation of AR variant binding to known AREs and Snail promoters from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
A) Validation of consititutive ARv567es binding to FASN and TSC2 AR binding sites in R1-D567 cells by ChIP-PCR; Examination of ARv567es binding events at putative AR binding sites within SNAI1 promoter region in R1-D567 by ChIP-PCR. Data f…
View article: Table S2: Correlation between EMP markers and AE signaling in MSKCC and TCGA datasets from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Table S2: Correlation between EMP markers and AE signaling in MSKCC and TCGA datasets from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
Correlation between EMP markers and AE signaling in MSKCC and TCGA datasets
View article: Figure S4: Evaluation of AR variant binding to known AREs and Snail promoters from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Figure S4: Evaluation of AR variant binding to known AREs and Snail promoters from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
A) Validation of consititutive ARv567es binding to FASN and TSC2 AR binding sites in R1-D567 cells by ChIP-PCR; Examination of ARv567es binding events at putative AR binding sites within SNAI1 promoter region in R1-D567 by ChIP-PCR. Data f…
View article: Data from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Data from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
Epithelial-to-mesenchymal plasticity (EMP) has been linked to metastasis, stemness, and drug resistance. In prostate cancer, EMP has been associated with both suppression and activation of the androgen receptor (AR) signaling. Here we inve…
View article: Data from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Data from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
Epithelial-to-mesenchymal plasticity (EMP) has been linked to metastasis, stemness, and drug resistance. In prostate cancer, EMP has been associated with both suppression and activation of the androgen receptor (AR) signaling. Here we inve…
View article: Figure S1: Effect of treatment protocol on AR gene expression in C4-2 and LAPC4 cells from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Figure S1: Effect of treatment protocol on AR gene expression in C4-2 and LAPC4 cells from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
C4-2 and LAPC4 cells were subjected to treatment protocol (Fig.1A); the canonical AR target genes including KLK3 and NKX3.1 were assessed by real-time PCR analysis. Data from three independent
View article: Figure S2: Effect of treatment protocol on migration in PC3 and PC-3(AR)2 cells from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Figure S2: Effect of treatment protocol on migration in PC3 and PC-3(AR)2 cells from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
PC3 and PC-3(AR)2 cells were subjected to the treatment protocol (Fig.1A). After 6 days of treatment, the monolayer surface was scratched carefully and washed. Wound healing at 24 hours under normal growth media conditions was quantitated.…
View article: Figure S5: Effect of androgen deprivation on EMP in xenografts from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Figure S5: Effect of androgen deprivation on EMP in xenografts from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
10 million C4-2 cells were injected subcutaneously into two locations into 8 nude mice. 4 mice (8 tumors) were subject to surgical castration, and the other 4 mice were left intact. Six days after surgery, the mice were sacrificed and the …
View article: Table S1: Primer sequence information from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Table S1: Primer sequence information from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer Open
Primers sequence information for qPCR and ChIP-qPCR