Jin Lu
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View article: SNRPA upregulation promotes mitochondrial function and drives CRPC aggressiveness
SNRPA upregulation promotes mitochondrial function and drives CRPC aggressiveness Open
Identifying novel molecular targets for castration-resistant prostate cancer (CRPC) is crucial. This study examines the expression and functional role of small nuclear ribonucleoprotein polypeptide A (SNRPA), a core component of the U1 snR…
View article: Hematological toxicity of immune checkpoint inhibitors: a pharmacovigilance study
Hematological toxicity of immune checkpoint inhibitors: a pharmacovigilance study Open
To our knowledge, this is among the first studies to utilize real-world big data for disproportionality analysis focused on ICI monotherapy, uncovering rare and severe hematological irAE. Multivariable logistic regression revealed that fol…
View article: An Active, Multimodal Neural Interface for Real‐Time Monitoring of Cortical Electrical, Thermal, and Optical Dynamics
An Active, Multimodal Neural Interface for Real‐Time Monitoring of Cortical Electrical, Thermal, and Optical Dynamics Open
Chronic neurophysiological monitoring devices facilitate the timely diagnosis and treatment of episodic or recurrent neurological disorders. Compared with passive electrodes, silicon‐based active transistors provide intrinsic signal amplif…
View article: Profound dFLC decrease after one cycle predicts superior outcome in patients with AL amyloidosis
Profound dFLC decrease after one cycle predicts superior outcome in patients with AL amyloidosis Open
The relationship between an early decrease in the difference between involved and uninvolved free light chains (dFLC) and clinical outcomes in AL amyloidosis is significant. We conducted a multicenter study (n = 86, baseline dFLC ≥ 50 mg/L…
View article: Longitudinal modeling of red blood cell distribution width dynamics and mortality risk in critically Ill patients with sepsis-associated acute kidney injury
Longitudinal modeling of red blood cell distribution width dynamics and mortality risk in critically Ill patients with sepsis-associated acute kidney injury Open
Background Sepsis-associated acute kidney injury (SA-AKI) is a critical condition with high mortality. Red cell distribution width (RDW) has emerged as a potential dynamic biomarker, but longitudinal RDW changes in SA-AKI remain underexplo…
View article: In-situ fabrication of Ce-doped CuAl-LDH@Ce composite superhydrophobic coating on 2219 aluminum alloy: Self-healing anti-corrosion performance and mechanism investigation
In-situ fabrication of Ce-doped CuAl-LDH@Ce composite superhydrophobic coating on 2219 aluminum alloy: Self-healing anti-corrosion performance and mechanism investigation Open
2219 aluminum alloy is widely used in shipbuilding for its high strength and light weight, but its high Cu content causes severe localized corrosion in marine environments, shortening service life. This study proposes a novel “in-situ grow…
View article: Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men
Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men Open
Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions…
View article: The Regulatory Role of LncRNAs in Modulating Autophagy and Drug Resistance in Non-Small-Cell Lung Cancer: Focus on Targeted Therapeutic Approaches
The Regulatory Role of LncRNAs in Modulating Autophagy and Drug Resistance in Non-Small-Cell Lung Cancer: Focus on Targeted Therapeutic Approaches Open
Lung cancer remains one of the leading causes of death associated with cancer globally, with non-small cell lung cancer (NSCLC) accounting for 80–85% of all lung cancer cases. Despite its high prevalence, the underlying mechanisms of NSCLC…
View article: High-Quality Financial Development and Rural–Urban Economic Integration: Coordinated Measurement and Spatiotemporal Evolution
High-Quality Financial Development and Rural–Urban Economic Integration: Coordinated Measurement and Spatiotemporal Evolution Open
Strengthening the coordinated development of high-quality financial development and urban–rural economic integration has become an inherent requirement for promoting rural revitalization. This study investigates the coordinated development…
View article: Updated overall survival data and predictive biomarkers of autologous NK cells plus Sintilimab as second-line treatment for advanced non-small cell lung cancer
Updated overall survival data and predictive biomarkers of autologous NK cells plus Sintilimab as second-line treatment for advanced non-small cell lung cancer Open
Purpose Combination strategies involving immune checkpoint inhibitors (ICIs) have been a prominent focus of research in the treatment of non-small cell lung cancer (NSCLC). Our prior findings demonstrated that the combination of autologous…
View article: A pharmacovigilance analysis of post-marketing safety of durvalumab
A pharmacovigilance analysis of post-marketing safety of durvalumab Open
Durvalumab has demonstrated significant efficacy in several types of malignancies, while large-scale real-world safety studies remain limited. This study aimed to systematically evaluate the safety of durvalumab through data mining of the …
View article: Prognostic impact of dynamic changes of type I melanoma antigen gene proteins CT7 (MAGE-C1/CT7) transcripts in multiple myeloma
Prognostic impact of dynamic changes of type I melanoma antigen gene proteins CT7 (MAGE-C1/CT7) transcripts in multiple myeloma Open
Type I melanoma antigen gene proteins CT7 ( MAGE-C1/CT7 ), a cancer-testis (CT) gene, correlated with clinical parameters at diagnosis of multiple myeloma (MM). We first analyzed single-cell ribonucleic acid sequencing data from public dat…
View article: Real-world analysis of treatment patterns, effectiveness, and safety of daratumumab-based regimens in Chinese patients with newly diagnosed or relapsed/refractory multiple myeloma
Real-world analysis of treatment patterns, effectiveness, and safety of daratumumab-based regimens in Chinese patients with newly diagnosed or relapsed/refractory multiple myeloma Open
Background Daratumumab is a human IgGκ monoclonal antibody targeting CD38 with direct on-tumor and immunomodulatory mechanisms of action. Daratumumab-based treatment is a standard of care for multiple myeloma (MM) based on data from random…
View article: Analysis of three treatment methods for granulomatous lobular mastitis: a retrospective study in a single center
Analysis of three treatment methods for granulomatous lobular mastitis: a retrospective study in a single center Open
Background Granulomatous lobular mastitis (GLM) is a rare, benign inflammatory condition of the breast that is difficult to distinguish from breast cancer on the basis of clinical and imaging findings. GLM typically has a long disease cour…
View article: Energy Transition and Household Carbon Emissions in China
Energy Transition and Household Carbon Emissions in China Open
This paper uses CFPS 2014, 2016, and 2018 micro‐survey data to measure the level of household carbon emissions and utilizes Chinese city data to construct a composite index to measure the development level of energy transition and then emp…
View article: De novo abnormalities identified by fluorescence in situ hybridization during follow-up confer poor prognosis in Chinese multiple myeloma
De novo abnormalities identified by fluorescence in situ hybridization during follow-up confer poor prognosis in Chinese multiple myeloma Open
Background Although there is evolving consensus to re-evaluate cytogenetic features during follow-up in multiple myeloma (MM), longitudinal studies on cytogenetic evolution in Chinese MM patients are still lacking. Our aim was to highlight…
View article: Sex differences in the prediction of metabolic abnormalities via body mass index in an Eastern Chinese population
Sex differences in the prediction of metabolic abnormalities via body mass index in an Eastern Chinese population Open
Objective Body mass index (BMI) is important for predicting the occurrence of metabolic abnormality, but sex differences exist. We aimed to investigate potential sex differences in the predictive value of BMI for metabolic abnormality and …
View article: Macrofocal multiple myeloma in the era of novel agents in China
Macrofocal multiple myeloma in the era of novel agents in China Open
Background: Macrofocal multiple myeloma (MFMM) is characterized by clonal plasma cells comprising less than 20% of the bone marrow, multiple lytic bone lesions, and the absence of anemia, renal insufficiency, and hypercalcemia. This subtyp…
View article: Obinutuzumab-induced acute thrombocytopenia: a case report and literature review
Obinutuzumab-induced acute thrombocytopenia: a case report and literature review Open
Background Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, is widely used in the treatment of B-cell lymphomas. Thrombocytopenia typically occurs 1 to 2 weeks after administration. In rare cases, obinutuzumab can induce se…
View article: Lenalidomide-induced pure red cell aplasia is associated with elevated expression of MHC-I molecules on erythrocytes
Lenalidomide-induced pure red cell aplasia is associated with elevated expression of MHC-I molecules on erythrocytes Open
The RVd therapy, combining lenalidomide, bortezomib, and dexamethasone, is a mainstay treatment for multiple myeloma. A multiple myeloma patient developed pure red cell aplasia (PRCA) following RVd treatment, despite the absence of common …
View article: Early dFLC response by C1D7 predicts complete hematologic response in systemic AL amyloidosis
Early dFLC response by C1D7 predicts complete hematologic response in systemic AL amyloidosis Open
Daratumumab and bortezomib, the first-line drugs for AL amyloidosis, typically yield a complete hematologic response (CHR) rate of nearly 60% when used in combinations. An early achievement of CHR is crucial in amyloidosis. We retrospectiv…
View article: Weekly Selinexor, Bortizomib and Dexamethasone (SVd) Versus Twice Weekly Bortizomib and Dexamethasone (Vd) in Chinese Patients with Relapsed and Refractory Multiple Myeloma (RRMM): Primary Analysis of Phase 3 Bench Study
Weekly Selinexor, Bortizomib and Dexamethasone (SVd) Versus Twice Weekly Bortizomib and Dexamethasone (Vd) in Chinese Patients with Relapsed and Refractory Multiple Myeloma (RRMM): Primary Analysis of Phase 3 Bench Study Open
Introduction: Selinexor (ATG-010) is a first-in-class, orally bioavailable XPO1 inhibitor which binds to exportin 1, inhibiting nuclear export of tumor suppressor proteins. It synergizes with proteasome inhibitors (PIs) in preclinical stud…
View article: Clinical Features and Prognostic Nomogram for Therapy-Related Acute Myeloid Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation
Clinical Features and Prognostic Nomogram for Therapy-Related Acute Myeloid Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation Open
Introduction: Therapy-related acute myeloid leukemia (t-AML) constitutes 10%-30% of newly diagnosed AML cases, is more resistant to conventional cytotoxic therapies, and has a greater relapse rate and poorer prognosis compared with de novo…
View article: An Uniquely Designed Asymmetric Bispecific Antibody Against GPRC5D and CD3 (LBL-034) in Patients with Relapsed/Refractory Multiple Myeloma: A Phase I/II, First in Human, Open-Label, Multicenter, Dose Escalation/Expansion Study
An Uniquely Designed Asymmetric Bispecific Antibody Against GPRC5D and CD3 (LBL-034) in Patients with Relapsed/Refractory Multiple Myeloma: A Phase I/II, First in Human, Open-Label, Multicenter, Dose Escalation/Expansion Study Open
Introduction: LBL-034 is a humanized IgG1 subtype asymmetric bispecific antibody targeting the G protein-coupled receptor class C group 5 member D (GPRC5D) and a cluster of differentiation 3 (CD3). LBL-034 can promote the proliferation and…
View article: The Race Against Time: Rapid Dflc Response in C1D7 Predicts Complete Hematologic Response in Systemic AL Amyloidosis
The Race Against Time: Rapid Dflc Response in C1D7 Predicts Complete Hematologic Response in Systemic AL Amyloidosis Open
Background: Daratumumab and bortezomib, the first-line regimens for AL amyloidosis, typically yield a complete hematologic response rate of nearly 60%. The median time to a hematologic response for the daratumumab based treatment is only 7…
View article: IgD型复发难治多发性骨髓瘤患者BCMA靶点再治疗1例报告并文献复习
IgD型复发难治多发性骨髓瘤患者BCMA靶点再治疗1例报告并文献复习 Open
Multiple myeloma（MM）is a malignant plasma cell disease that currently cannot be cured. Several new drugs have continuously been introduced in the recent years. New drugs targeting B-cell maturation antigen（BCMA）have greatly improved the ef…
View article: The clinical significance and anti-tumor role of PRKG1 in bladder cancer
The clinical significance and anti-tumor role of PRKG1 in bladder cancer Open
Introduction cGMP-dependent protein kinase 1 (PRKG1) has shown to be associated with some tumorigenesis, while the role of PRKG1 in bladder cancer is unclear. Methods To investigate the biological and clinical significance of PRKG1 in blad…