Shan Zeng
YOU?
Author Swipe
View article: Unraveling the genetic association between autoimmune thyroid diseases and idiopathic inflammatory myopathies in the European population
Unraveling the genetic association between autoimmune thyroid diseases and idiopathic inflammatory myopathies in the European population Open
While clinical observations suggest potential links between thyroid autoimmunity disorders (specifically Hashimoto thyroiditis and Graves’ disease) and idiopathic inflammatory myopathies (notably dermatomyositis and polymyositis), the unde…
View article: Development and clinical trial of M701, an Anti-EpCAM × Anti-CD3 bispecific antibody: a targeted intraperitoneal therapy for malignant ascites stemming from advanced solid tumors
Development and clinical trial of M701, an Anti-EpCAM × Anti-CD3 bispecific antibody: a targeted intraperitoneal therapy for malignant ascites stemming from advanced solid tumors Open
Background Malignant ascites (MA) is one of the major complications in advanced epithelial cancer patients and is associated with poor prognosis, poor quality of life, and severe symptoms. No efficient medicine is available for treating MA…
View article: Insights into the Adaptive Evolution of Cinnamomum burmanni Through TMT Proteomic and RNA-Seq Analyses
Insights into the Adaptive Evolution of Cinnamomum burmanni Through TMT Proteomic and RNA-Seq Analyses Open
Cinnamomum burmanni (Nees & T. Nees) Blume, a member of the Lauraceae family, exhibits adaptability to diverse environmental conditions by synthesizing a diverse array of specialized secondary metabolites, including terpenoids and cinnamal…
View article: Characterization of an Ischemia-Reperfusion Model for the Formation of a Stage II Pressure Injury in Diabetic Mice
Characterization of an Ischemia-Reperfusion Model for the Formation of a Stage II Pressure Injury in Diabetic Mice Open
Introduction: Pressure injuries (PIs) in patients with diabetes mellitus still impact patients’ health and place a heavy burden on healthcare systems. Stage I and stage II PIs are particularly prevalent among individuals with diabetes. Wit…
View article: Development and Clinical Trial of M701, an Anti-EpCAM × Anti-CD3 Bispecific Antibody: A Targeted Intraperitoneal Therapy for Malignant Ascites Stemming from Advanced Solid Tumors
Development and Clinical Trial of M701, an Anti-EpCAM × Anti-CD3 Bispecific Antibody: A Targeted Intraperitoneal Therapy for Malignant Ascites Stemming from Advanced Solid Tumors Open
Background Malignant ascites (MA) is one of the major complications in advanced epithelial cancer patients and is associated with poor prognosis, poor quality of life, and severe symptoms. No efficient medicine is available for treating MA…
View article: Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment
Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment Open
Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most frequently mutated member of the RAS family of small GTPases (RAS). It affects about one‐fifth of cancer cases. The tumor microenvironment (TME) is a multifaceted network of imm…
View article: Association between systemic Immune-inflammation index, systemic inflammation response index and adult osteoarthritis: national health and nutrition examination survey
Association between systemic Immune-inflammation index, systemic inflammation response index and adult osteoarthritis: national health and nutrition examination survey Open
Not applicable.
View article: PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer
PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer Open
Microsatellite stable (MSS) colorectal cancer (CRC) is considered an “immune‐cold” tumor, accounting for ≈85% of all CRC cases. The overall response rate to chemotherapy combined with immune checkpoint inhibitors in MSS CRC is typically le…
View article: The molecular characteristics of DNA damage and repair related to P53 mutation for predicting the recurrence and immunotherapy response in hepatocellular carcinoma
The molecular characteristics of DNA damage and repair related to P53 mutation for predicting the recurrence and immunotherapy response in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally, owing to its high recurrence rate of 50 to 70% within five years. Despite known associations of certain DNA damage and repair (DDR) genes with t…
View article: Activation and inhibition of Notch signaling facilitate proliferative regeneration of sensory cells in adult mice
Activation and inhibition of Notch signaling facilitate proliferative regeneration of sensory cells in adult mice Open
Due to the limited regenerative capacity in adult mammals, the loss of vestibular hair cells (HCs) leads to balance disorders. In this study, we chronologically reprogrammed adult vestibular supporting cells (SCs) via bimodal regulation of…
View article: Dietary Fructose Suppresses Hepatocellular Carcinogenesis through Fructose 1-Phosphate-Mediated Inhibition of Mannose Phosphate Isomerase
Dietary Fructose Suppresses Hepatocellular Carcinogenesis through Fructose 1-Phosphate-Mediated Inhibition of Mannose Phosphate Isomerase Open
Fructose consumption increases risks of obesity-related metabolic diseases and some cancers, but remains controversial in hepatocellular carcinoma (HCC)1. Animal studies suggest high fructose promotes HCC2,3, whereas human studies found an…
View article: Nucleic Acid‐Locked Smart Carrier for Photothermal/Chemotherapy‐Amplified Immunogenic Cell Death to Enhance Systemic Antitumor Efficacy
Nucleic Acid‐Locked Smart Carrier for Photothermal/Chemotherapy‐Amplified Immunogenic Cell Death to Enhance Systemic Antitumor Efficacy Open
Immunotherapy holds great promise in the fight against cancer; however, it often encounters poor immunogenicity with limited therapeutic efficacy. Combining multiple treatment modalities provides a trustworthy strategy for achieving a robu…
View article: Nonlinear dose–response relationship between prognostic nutritional index and short-term outcome in acute ischemic stroke: a prospective cohort study
Nonlinear dose–response relationship between prognostic nutritional index and short-term outcome in acute ischemic stroke: a prospective cohort study Open
Objective The evidence surrounding the connection between the Prognostic Nutritional Index (PNI) and the prognosis of patients with Acute Ischemic Stroke (AIS) remains insufficient. Therefore, this study is designed to examine how PNI rela…
View article: Artificial intelligence predicts multiclass molecular signatures and subtypes directly from breast cancer histology: a multicenter retrospective study
Artificial intelligence predicts multiclass molecular signatures and subtypes directly from breast cancer histology: a multicenter retrospective study Open
Detection of biomarkers of breast cancer incurs additional costs and tissue burden. We propose a deep learning-based algorithm (BBMIL) to predict classical biomarkers, immunotherapy-associated gene signatures, and prognosis-associated subt…
View article: Effect of low-dose radiation pre-irradiation on postoperative local chest wall recurrence of breast cancer—A retrospective study
Effect of low-dose radiation pre-irradiation on postoperative local chest wall recurrence of breast cancer—A retrospective study Open
Purpose The purpose of this study was to determine the efficacy and safety of low-dose radiotherapy (LDR) for postoperative local chest wall recurrence of breast cancer. Methods The records of 52 patients with postoperative local chest wal…
View article: Research on Wide Area Network Performance Anomaly Detection Technology Based on Machine Learning
Research on Wide Area Network Performance Anomaly Detection Technology Based on Machine Learning Open
The upgrade of the IHEP WLCG Tier-1 site’s network bandwidth from 40 Gbps to 100 Gbps demands robust performance monitoring to ensure reliability. Traditional methods face inefficiencies in pinpointing anomalies within large-scale networks…
View article: Artemisinin Suppressed Melanoma Recurrence and Metastasis after Radical Surgery through the KIT/PI3K/AKT Pathway
Artemisinin Suppressed Melanoma Recurrence and Metastasis after Radical Surgery through the KIT/PI3K/AKT Pathway Open
Cancer radical surgery is the primary treatment for melanoma, but almost all malignant melanoma patients get recurrence and metastasis after surgery and are eventually dead. This clinical dilemma appeals to better drugs for post-surgery th…