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View article: Hypoxic tumor exosomes suppress macrophage inflammation and ferroptosis via NDUFV2 to enhance bystander tumor radioresistance
Hypoxic tumor exosomes suppress macrophage inflammation and ferroptosis via NDUFV2 to enhance bystander tumor radioresistance Open
Hypoxia-induced radioresistance presents a major barrier to effective radiotherapy of non-small cell lung cancer (NSCLC), while the underlying role of macrophages remaining elusive. In this study, we found that, compared with normoxia-deri…
View article: Structural insights into cationic amino acid transport and viral receptor engagement by CAT1
Structural insights into cationic amino acid transport and viral receptor engagement by CAT1 Open
Cationic amino acid transporter 1 (CAT1) transports cationic amino acids and plays pivotal roles in cancer proliferation, immune modulation, and nitric oxide metabolism. It also serves as the specific cellular receptor for certain murine l…
View article: Mesenchymal stem cell–derived small extracellular vesicles (sEVs) as a therapy for sepsis-related liver injury: evidence from a systematic review and meta-analysis
Mesenchymal stem cell–derived small extracellular vesicles (sEVs) as a therapy for sepsis-related liver injury: evidence from a systematic review and meta-analysis Open
Background Sepsis-induced liver injury (SILI) is critical in the progression of high morbidity and mortality associated with sepsis which ends in hepatic dysfunction and multi-organ failure. Mesenchymal stem cell–derived small extracellula…
View article: A model based on PT-INR and age serves as a promising predictor for evaluating mortality risk in patients with SARS-CoV-2 infection
A model based on PT-INR and age serves as a promising predictor for evaluating mortality risk in patients with SARS-CoV-2 infection Open
COVID-19 caused by the coronavirus SARS-CoV-2 has resulted in a global pandemic. Considering some patients with COVID-19 rapidly develop respiratory distress and hypoxemia, early assessment of the prognosis for COVID-19 patients is importa…
View article: Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses
Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses Open
Introduction Recent findings reveal that the precursors of exhausted CD8 + T (CD8 + Tpex) cells possess stem-like signatures in tumor immunity, which originate from tumor draining lymph node (TdLN)-derived tumor-specific memory (CD8 + T TS…
View article: Reduction of <scp>DNA</scp> Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species
Reduction of <span>DNA</span> Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species Open
DNA topoisomerases are essential molecular machines that manage DNA topology in the cell and play important roles in DNA replication and transcription. We found that knocking down the enzyme topoisomerase Top2 or its mammalian homolog TOP2…
View article: Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation
Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation Open
Delayed effects of significantly declined lung function and high mortality were observed in the sRRLI model. DAD with progressive inflammation and fibrosis in bilateral lungs contributed to severe or even fatal complications after partial …
View article: Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species Open
DNA topoisomerases are essential molecular machines that manage DNA topology in the cell and play important roles in DNA replication and transcription. We find that knocking down the enzyme Topoisomerase Top2 or its mammalian homolog Top2b…
View article: Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species Open
DNA topoisomerases are essential molecular machines that manage DNA topology in the cell and play important roles in DNA replication and transcription. We find that knocking down the enzyme Topoisomerase Top2 or its mammalian homolog Top2b…
View article: Addressing functional constipation in children: A call for comprehensive and collaborative management
Addressing functional constipation in children: A call for comprehensive and collaborative management Open
Functional constipation (FC) is the most common gastrointestinal disorder in children, with a global prevalence of 14.4% based on Rome IV criteria. This editorial explores the multifactorial pathogenesis and diagnostic complexity of FC, em…
View article: Research Progress of Alzheimer’s Disease Monoclonal Antibodiesand Their Safety Assessments
Research Progress of Alzheimer’s Disease Monoclonal Antibodiesand Their Safety Assessments Open
This article focused on discussing two monoclonal antibodies (mAbs), lecanemab and aducanumab, which target at amyloid-beta protofibrils and fibrils as amyloid-beta plaques are considered as the key pathogenesis of Alzheimer’s disease (AD)…
View article: Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species Open
DNA topoisomerases are essential molecular machines that manage DNA topology in the cell and play important roles in DNA replication and transcription. We find that knocking down the enzyme Topoisomerase Top2 or its mammalian homolog Top2b…
View article: Inflammatory markers correlate with lymphocytes infiltrating and predict immunotherapy prognosis for esophageal cancer
Inflammatory markers correlate with lymphocytes infiltrating and predict immunotherapy prognosis for esophageal cancer Open
Aim: To investigate the prognostic value of inflammatory markers in esophageal squamous cell carcinoma (ESCC) patients treated with immune checkpoint inhibitors (ICIs).Materials & methods: The infiltration of CD3+ and CD8+ T cells in tissu…
View article: Structural insights into the recognition of purine‐pyrimidine dinucleotide repeats by zinc finger protein <scp>ZBTB43</scp>
Structural insights into the recognition of purine‐pyrimidine dinucleotide repeats by zinc finger protein <span>ZBTB43</span> Open
Purine‐pyrimidine repeats (PPRs) can form left‐handed Z‐form DNA and induce DNA double‐strand breaks (DSBs), posing a risk for genomic rearrangements and cancer. The zinc finger (ZF) and BTB domain‐containing protein 43 (ZBTB43) is a trans…
View article: Optimisation of Not-from-Concentrate Goji Juice Processing Using Fuzzy Mathematics and Response Surface Methodology and Its Quality Assessment
Optimisation of Not-from-Concentrate Goji Juice Processing Using Fuzzy Mathematics and Response Surface Methodology and Its Quality Assessment Open
Not-from-concentrate (NFC) juice effectively retains the original characteristics of the fruit. Despite the various health benefits of Goji berries, reports on the processing technology and quality changes of NFC goji juice are lacking. We…
View article: Toralactone alleviates cisplatin-induced acute kidney injury by modulating the gut microbiota-renal axis
Toralactone alleviates cisplatin-induced acute kidney injury by modulating the gut microbiota-renal axis Open
This study elucidated the reno-protective effects for the first time, demonstrating that it exerts its beneficial effects through the gut microbiota, which mediate the LPS/TLR4/NF-κB/TNF-α inflammatory pathway. It may help to develop thera…
View article: Bilateral diffuse alveolar damage contributes to the fatal toxicity of pre-existing interstitial lung disease mice after partial thoracic irradiation
Bilateral diffuse alveolar damage contributes to the fatal toxicity of pre-existing interstitial lung disease mice after partial thoracic irradiation Open
Background Lung cancer patients with comorbid interstitial lung disease (LC-ILD) have an increased risk of developing severe or even fatal radiation pneumonitis after thoracic radiotherapy. However, the underlying mechanisms of its pathoge…
View article: Regulator of G protein signaling 20 contributes to radioresistance of non-small cell lung cancer cells by suppressing pyroptosis
Regulator of G protein signaling 20 contributes to radioresistance of non-small cell lung cancer cells by suppressing pyroptosis Open
Objective: To investigate the potential role of the regulator of G protein signaling 20 (RGS20) in radioresistance of non-small cell lung cancer (NSCLC). Methods: A total of 35 lung adenocarcinoma (LUAD) patients from The Cancer Genome Atl…
View article: Interaction of SENP6 with PINK1 promotes temozolomide resistance in neuroglioma cells via inducing the mitophagy
Interaction of SENP6 with PINK1 promotes temozolomide resistance in neuroglioma cells via inducing the mitophagy Open
Temozolomide resistance is a major cause of recurrence and poor prognosis in neuroglioma. Recently, growing evidence has suggested that mitophagy is involved in drug resistance in various tumor types. However, the role and molecular mechan…
View article: Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway
Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway Open
Patients who receive thoracic radiotherapy may suffer from radiation-induced lung injury, but the treatment options are limited as the underlying mechanisms are unclear. Using a mouse model of right thorax irradiation with fractionated dos…
View article: Characteristics of gut microbiota determine effects of specific probiotics strains in patients with functional constipation
Characteristics of gut microbiota determine effects of specific probiotics strains in patients with functional constipation Open
To the Editor: Probiotics are a promising treatment modality for functional constipation (FC); however, the factors affecting individual responses to probiotics remain unclear. Growing evidence has identified that there is a strong relatio…
View article: Aggrephagy-related patterns in tumor microenvironment, prognosis, and immunotherapy for acute myeloid leukemia: a comprehensive single-cell RNA sequencing analysis
Aggrephagy-related patterns in tumor microenvironment, prognosis, and immunotherapy for acute myeloid leukemia: a comprehensive single-cell RNA sequencing analysis Open
Acute myeloid leukemia (AML) is a complex mixed entity composed of malignant tumor cells, immune cells and stromal cells, with intra-tumor and inter-tumor heterogeneity. Single-cell RNA sequencing enables a comprehensive study of the highl…
View article: P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin
P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin Open
Background Interstitial lung diseases (ILDs) can be induced and even exacerbated by radiotherapy in thoracic cancer patients. The roles of immune responses underlying the development of these severe lung injuries are still obscure and need…
View article: LncRNA CASC19 Enhances the Radioresistance of Nasopharyngeal Carcinoma by Regulating the miR-340-3p/FKBP5 Axis
LncRNA CASC19 Enhances the Radioresistance of Nasopharyngeal Carcinoma by Regulating the miR-340-3p/FKBP5 Axis Open
Radioresistance remains a serious obstacle encountered in the radiotherapy of nasopharyngeal carcinoma (NPC). Both mRNAs and non-coding RNAs (ncRNAs), including long ncRNA (lncRNA) and microRNA (miRNA), play essential roles in radiosensiti…
View article: SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes
SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes Open
Rationale: Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Radiotherapy has long been an important treatment for GBM. Despite recent advances in tumor radiotherapy, the prognosis of GBM remains poor due t…
View article: GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells
GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells Open
Radiotherapy is one of the conventional methods for the clinical treatment of breast cancer. However, radioresistance has an adverse effect on the prognosis of breast cancer patients after radiotherapy. In this study, using bioinformatic a…