Luana Mathieu
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View article: Artemisinin pressure in field isolates can select highly resistant <i>Plasmodium falciparum</i> parasites with unconventional phenotype and no K13 mutation
Artemisinin pressure in field isolates can select highly resistant <i>Plasmodium falciparum</i> parasites with unconventional phenotype and no K13 mutation Open
Artemisinin resistance, which poses a serious threat to malaria control efforts, is monitored in the field by delayed parasite clearance in patients, elevated parasite survival rate in the ring-stage survival assay, and mutations in the Pl…
View article: Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana
Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana Open
Plasmodium parasites, the causal agents of malaria, are eukaryotic organisms that obligately undergo sexual recombination within mosquitoes. In low transmission settings, parasites recombine with themselves, and the clonal lineage is propa…
View article: Temporal and spatial dynamics of<i>Plasmodium falciparum</i>clonal lineages in Guyana
Temporal and spatial dynamics of<i>Plasmodium falciparum</i>clonal lineages in Guyana Open
Plasmodium parasites, the causal agents of malaria, are eukaryotic organisms that obligately undergo sexual recombination within mosquitoes. However, in low transmission settings where most mosquitoes become infected with only a single par…
View article: Determination of different social groups’ level of knowledge about malaria in a multicultural Amazonian cross-border context
Determination of different social groups’ level of knowledge about malaria in a multicultural Amazonian cross-border context Open
Background A steady decline in the number of cases of malaria was observed in the 2000s in French Guiana. This enabled regional health policies to shift their public health goal from control to elimination. To include inhabitants in this s…
View article: Kelch13 mutations in <i>Plasmodium falciparum</i> and risk of spreading in Amazon basin countries
Kelch13 mutations in <i>Plasmodium falciparum</i> and risk of spreading in Amazon basin countries Open
Background The first potential focus for artemisinin resistance in South America was recently confirmed with the presence of the C580Y mutation in the Plasmodium falciparum kelch 13 gene (pfk13) in Guyana. Objectives This study aimed to st…
View article: Field Performance of Mass PCR Screening and Targeted Treatment in an Amazonian Low Malaria Transmission Setting
Field Performance of Mass PCR Screening and Targeted Treatment in an Amazonian Low Malaria Transmission Setting Open
The three main obstacles to the elimination of malaria in French Guiana are asymptomatic carriers of Plasmodium vivax , relapses and, to a lesser extent, Plasmodium falciparum . This study aims to assess the impact of PCR-based mass screen…
View article: Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control
Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control Open
BACKGROUND Aedes aegypti is the sole vector of urban arboviruses in French Guiana. Overtime, the species has been responsible for the transmission of viruses during yellow fever, dengue, chikungunya and Zika outbreaks. Decades of vector co…
View article: Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance
Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance Open
Antimalarial drug resistance has historically arisen through convergent de novo mutations in Plasmodium falciparum parasite populations in Southeast Asia and South America. For the past decade in Southeast Asia, artemisinins, the core comp…
View article: Author response: Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance
Author response: Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Antimalarial drug resistance …
View article: Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control
Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control Open
The resistance level can jeopardize the efficiency of chemical adult control in absence of other alternatives and conducts to strongly rely on larval control measures to reduce mosquito burden. Vector control strategies need to evolve to m…
View article: Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana–Brazil): Associated Factors and Spatial Distribution
Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana–Brazil): Associated Factors and Spatial Distribution Open
To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipalit…