Jean‐Luc Boucher
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View article: S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors
S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors Open
We previously reported dipeptidomimetic compounds as inhibitors of neuronal and/or inducible NO synthases (n/iNOS) with significant selectivity against endothelial NOS (eNOS). They were composed of an S-ethylisothiocitrullin-like moiety li…
View article: Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B4
Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B4 Open
Cytochrome P450 2U1 (CYP2U1) identified from the human genome remains poorly known since few data are presently available on its physiological function(s) and substrate(s) specificity. CYP2U1 mutations are associated with complicated forms…
View article: Reactions of Recombinant Neuronal Nitric Oxide Synthase with Redox Cycling Xenobiotics: A Mechanistic Study
Reactions of Recombinant Neuronal Nitric Oxide Synthase with Redox Cycling Xenobiotics: A Mechanistic Study Open
Neuronal nitric oxide synthase (nNOS) catalyzes single-electron reduction of quinones (Q), nitroaromatic compounds (ArNO2) and aromatic N-oxides (ArN → O), and is partly responsible for their oxidative stress-type cytotoxicity. In order to…
View article: Implication of folate deficiency in CYP2U1 loss of function
Implication of folate deficiency in CYP2U1 loss of function Open
Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders. Understanding of their pathogenic mechanisms remains sparse, and therapeutic options are lacking. We characterized a mouse model lacking the Cyp2u1 gene, loss of…
View article: Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration
Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration Open
Specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS), two enzymes associated with redox stress in tumor cells, has aroused great pharmacological interest. Here, we show how these enzymes distinguish between isomeric 2′- and 3…
View article: Pseudoxanthoma elasticum overlaps hereditary spastic paraplegia type 56
Pseudoxanthoma elasticum overlaps hereditary spastic paraplegia type 56 Open
Purpose Pseudoxanthoma elasticum (PXE) is a recessive disorder involving skin, eyes and arteries, mainly caused by ABCC6 pathogenic variants. However, almost one fifth of patients remain genetically unsolved despite extensive genetic scree…
View article: Comparison of Various Aryl-Dithiolethiones and Aryl-Dithiolones As Hydrogen Sulfide Donors in the Presence of Rat Liver Microsomes
Comparison of Various Aryl-Dithiolethiones and Aryl-Dithiolones As Hydrogen Sulfide Donors in the Presence of Rat Liver Microsomes Open
View article: Solid‐Phase Synthesis of Substrate‐Based Dipeptides and Heterocyclic Pseudo‐dipeptides as Potential NO Synthase Inhibitors
Solid‐Phase Synthesis of Substrate‐Based Dipeptides and Heterocyclic Pseudo‐dipeptides as Potential NO Synthase Inhibitors Open
More than 160 arginine analogues modified on the C‐terminus via either an amide bond or a heterocyclic moiety (1,2,4‐oxadiazole, 1,3,4‐oxadiazole and 1,2,4‐triazole) were prepared as potential inhibitors of NO synthases (NOS). A methodolog…
View article: Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes Open
View article: Light-induced formation of NO in endothelial cells by photoactivatable NADPH analogues targeting nitric-oxide synthase
Light-induced formation of NO in endothelial cells by photoactivatable NADPH analogues targeting nitric-oxide synthase Open
View article: Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase
Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase Open
Nitric oxide ( NO ) produced by mammalian nitric oxide synthases ( mNOS s) is an important mediator in a variety of physiological functions. Crystal structures of mNOS s have shown strong conservation of the active‐site residue Val567 (num…
View article: Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways
Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways Open
View article: INTRODUCTION : Fluindione (2-(4'fluoro-phenyl Cytochrome P450 dependent metabolism of fluindione in vitro in rat and human microsomes and in vivo in rat
INTRODUCTION : Fluindione (2-(4'fluoro-phenyl Cytochrome P450 dependent metabolism of fluindione in vitro in rat and human microsomes and in vivo in rat Open
View article: CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56
CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56 Open
Hereditary spastic paraplegia (HSP) is an inherited disorder of the central nervous system mainly characterized by gradual spasticity and weakness of the lower limbs. SPG56 is a rare autosomal recessive early onset complicated form of HSP …
View article: Membrane-bound human orphan cytochrome P450 2U1: Sequence singularities, construction of a full 3D model, and substrate docking
Membrane-bound human orphan cytochrome P450 2U1: Sequence singularities, construction of a full 3D model, and substrate docking Open
This model should be useful to find new endogenous or exogenous CYP2U1 substrates and to interpret the regioselectivity of their hydroxylation.
View article: Cytochrome P450 2U1, a very peculiar member of the human P450s family
Cytochrome P450 2U1, a very peculiar member of the human P450s family Open
View article: Mechanism of melanoma cells selective apoptosis induced by a photoactive NADPH analogue
Mechanism of melanoma cells selective apoptosis induced by a photoactive NADPH analogue Open
Melanoma is one of the most lethal cancers when it reaches a metastatic stage. Despite the spectacular achievements of targeted therapies (BRAF inhibitors) or immuno-therapies (anti-CTLA4 or anti-PD1), most patients with melanoma will need…
View article: Oxygen activation in <scp>NO</scp> synthases: evidence for a direct role of the substrate
Oxygen activation in <span>NO</span> synthases: evidence for a direct role of the substrate Open
Nitric oxide ( NO ) and the other reactive nitrogen species ( RNOS ) play crucial patho‐physiological roles at the interface of oxidative stress and signalling processes. In mammals, the NO synthases ( NOS s) are the source of these reacti…
View article: TLR4/IFNγ pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models
TLR4/IFNγ pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models Open
Toll-like receptor (TLR) 4 agonists have emerged as a new group of molecules used for cancer therapy. They have been exploited to enhance the immunogenicity of current chemotherapeutic regimens. However, their effects on cancer cells remai…
View article: New 1,4‐Dihydropyridines Down‐regulate Nitric Oxide in Animals with Streptozotocin‐induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action
New 1,4‐Dihydropyridines Down‐regulate Nitric Oxide in Animals with Streptozotocin‐induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action Open
Diabetes mellitus ( DM ) and its complications cause numerous health and social problems throughout the world. Pathogenic actions of nitric oxide ( NO ) are responsible to a large extent for development of complications of DM . Search for …