Explanipedia

Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open

Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E. Justice, Geetha Chittoor, Hung‐Hsin Chen , et al. · 2025

Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…

Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open

Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E. Justice, Geetha Chittoor, Hung‐Hsin Chen , et al. · 2025

Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…

Advanced Glycation End‐Product Carboxymethyl‐Lysine and Incident Heart Failure and Atrial Fibrillation in Older Adults Open

Yakubu Bene‐Alhasan, Traci M. Bartz, Luc Djoussé, Joachim H. Ix, David S. Siscovick , et al. · 2025

Background Advanced glycation end‐products result from chemical modification of proteins under conditions of hyperglycemia or oxidative stress common with advancing age. Advanced glycation end‐product (AGE) formation alters vascular and ca…

A contextual genomic perspective on physical activity and its relationship to health, well being and illness Open

Marco Galimberti, Daniel F. Levey, Joseph D. Deak, Keyrun Adhikari, Cassie Overstreet , et al. · 2025

The Veterans Affairs Lipid Optimization Reimagined - Quality Improvement Program Rationale and Methods Open

Abigail Santos, Jennifer DelGrande, Andrej Fink, Juhi Seth, Courtney Bonnema , et al. · 2025

Background: Atherosclerotic cardiovascular disease (ASCVD) is a major contributor to morbidity and mortality in United States (US) Veterans and to healthcare costs in the United States Veterans Affairs (VA) Healthcare System. Optimizing Lo…

Albuminuria, structural brain findings and Circulating biomarkers of brain injury in older adults Open

Jens W. Horn, Alison E. Fohner, Russell P. Tracy, Hieab H.H. Adams, Luc Djoussé , et al. · 2025

Albuminuria reflects systemic endothelial dysfunction, but its relationships with subclinical brain abnormalities have not been comprehensively catalogued. The Cardiovascular Health Study recruited older adults from four US communities, be…

A contextual genomic perspective on physical activity and its relationship to health, well-being and illness Open

Marco Galimberti, Daniel F. Levey, Joseph D. Deak, Keyrun Adhikari, Cassie Overstreet , et al. · 2025

Physical activity (PA) is one of the most fundamental of all traits in the animal kingdom, has pervasive health benefits, and is genetically influenced. Using data from the Million Veteran Program (MVP), we conducted genetic analyses of le…

Non-Esterified Fatty Acid Profiles and Cause-Specific Mortality: The Cardiovascular Health Study Open

Yakubu Bene‐Alhasan, Sanyog G. Shitole, Petra Bůžková, Calvin H. Hirsch, Joachim H. Ix , et al. · 2025

Context Total fasting non-esterified fatty acid (NEFA) levels have been associated with mortality. The corresponding associations with NEFA levels following an oral glucose tolerance test (OGTT) and with individual fasting NEFA species are…

Dietary Cholesterol and Myocardial Infarction in the Million Veteran Program Open

Xuan‐Mai T. Nguyen, Yanping Li, Mark S. Nyaeme, Neha Panigrahy, Serena C. Houghton , et al. · 2025

Background Coronary artery disease is a leading cause of morbidity and mortality in the United States. Coronary artery disease can lead to major complications including myocardial infarction (MI). The association of dietary cholesterol wit…

Potato Consumption and Risk of Cardiovascular Disease in a Harmonized Analysis of Seven Prospective Cohorts Open

Luc Djoussé, Xia Zhou, Jaewon Lim, Eunjung Kim, Howard D. Sesso , et al. · 2025

Background/Objectives: While previous study results have suggested an elevated risk of type 2 diabetes with potato consumption, limited and inconsistent results are available on the association of potato consumption with the risk of cardio…

Sleep disordered breathing and circulating non-esterified fatty acids: the cardiovascular health study Open

Peter Ahiawodzi, Russell P. Tracy, Jorge R. Kizer, Susan Redline, Luc Djoussé , et al. · 2025

Study Objectives Circulating non-esterified fatty acids (NEFAs) have been associated with impaired glucose metabolism but their modifiable determinants remain uncertain. We sought to determine the association between objectively-measured s…

Rationale and Design of a Randomized Controlled Trial Evaluating the Effects of Blueberry Consumption Versus Placebo on Brain Health in Older Adults Open

Zachary Uttke, O.E. Gabriel, Christopher C. Smith, Ellie Guardino, Kenneth J. Mukamal , et al. · 2025

Risk of Incident Cancer in Veterans with Diabetes Who Use Metformin Versus Sulfonylureas Open

Maya Abdallah, Beatriz Desanti de Oliveira, Clark DuMontier, Ariela R. Orkaby, Lisa Nussbaum , et al. · 2024

Prior research suggests metformin has anti-cancer effects, yet data are limited. We examined the association between diabetes treatment (metformin versus sulfonylurea) and risk of incident diabetes-related and non- diabetes-related cancers…

Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities Open

Mohammad Abdel Jawad, James H. O’Keefe, Nathan Tintle, Evan L. O’Keefe, William Grant Franco , et al. · 2024

Racial and Ethnic Disparities in Dietary Intake and Quality Among United States Veterans Open

Xuan‐Mai T. Nguyen, Yanping Li, Stacey B. Whitbourne, Luc Djoussé, Dong D. Wang , et al. · 2024

Potato Consumption and Risk of Type 2 Diabetes Mellitus: A Harmonized Analysis of 7 Prospective Cohorts Open

Luc Djoussé, Xia Zhou, Jaewon Lim, Eunjung Kim, Howard D. Sesso , et al. · 2024

Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration Open

Shahzad Ahmad, Mohammad Aslam Imtiaz, Aniket Mishra, Ruiqi Wang, Marisol Herrera-Rivero , et al. · 2024

Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries Open

Chunxiao Li, Tom Bishop, Fumiaki Imamura, Stephen J. Sharp, Matthew Pearce , et al. · 2024

BACKGROUND: Meat consumption could increase the risk of type 2 diabetes. However, evidence is largely based on studies of European and North American populations, with heterogeneous analysis strategies and a greater focus on red meat than …

Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries Open

Chunxiao Li, Tom Bishop, Fumiaki Imamura, Stephen J. Sharp, Matthew Pearce , et al. · 2024

Measuring Frailty Using Self‐Report or Automated Tools to Identify Risk of Cardiovascular Events and Mortality: The Million Veteran Program Open

Saadia Qazi, Benjamin Seligman, Sarah R. Preis, Manas Rane, Luc Djoussé , et al. · 2024

Background Frailty, a syndrome of physiologic vulnerability, increases cardiovascular disease (CVD) risk. Whether in person or automated frailty tools are ideal for identifying CVD risk remains unclear. We calculated 3 distinct frailty sco…

Spironolactone Reduces the Risk of Death in Veterans With Heart Failure With Preserved Ejection Fraction Open

Katherine E. Kurgansky, Rachel Parker, Luc Djoussé, David Gagnon, Jacob Joseph · 2024

Background Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome increasing in prevalence and affecting millions worldwide but with limited evidence‐based therapies. Results from explanatory clinical trials suggest t…

The state of the science on the health benefits of blueberries: a perspective Open

April J. Stull, Aedín Cassidy, Luc Djoussé, Sarah A. Johnson, Robert Krikorian , et al. · 2024

Mounting evidence indicates that blueberry consumption is associated with a variety of health benefits. It has been suggested that regular consumption of blueberries can support and/or protect against cardiovascular disease and function, p…

Circulating sphingolipids and subclinical brain pathology: the cardiovascular health study Open

Kristine F. Moseholm, Jens W. Horn, Annette L. Fitzpatrick, Luc Djoussé, W.T. Longstreth , et al. · 2024

Background Sphingolipids are implicated in neurodegeneration and neuroinflammation. We assessed the potential role of circulating ceramides and sphingomyelins in subclinical brain pathology by investigating their association with brain mag…

Data Resource Profile: Nutrition Data in the VA Million Veteran Program Open

Xuan‐Mai T. Nguyen, Yanping Li, Kerry L. Ivey, Stacey B. Whitbourne, Walter C. Willett , et al. · 2024

IntroductionThe Department of Veterans Affairs (VA) Million Veteran Program (MVP) nutrition data is derived from dietary food/beverage intake information collected through a semiquantitative food frequency questionnaire (SFFQ). MethodsEsti…

Initiation of Statins for Primary Prevention in Heart Failure With Preserved Ejection Fraction Open

Ariela R. Orkaby, Parag Goyal, Brian Charest, Saadia Qazi, Shamlan Sheikh , et al. · 2024

Associations of Neurological Biomarkers in Serum With Gait Measures: The Cardiovascular Health Study Open

Abhijay N Nadkarni, Kenneth J. Mukamal, Xiaonan Zhu, David S. Siscovick, Jennifer S. Brach , et al. · 2024

Background Gait impairment leads to increased mobility decline and may have neurological contributions. This study explores how neurological biomarkers are related to gait in older adults. Methods We studied participants in the Cardiovascu…

Moderate alcohol consumption on the risk of stroke in the Million Veteran Program Open

Rebecca J. Song, Martin G. Larson, Hugo J. Aparicio, J. Michael Gaziano, Peter W.F. Wilson , et al. · 2023

Statins, Mortality, and Major Adverse Cardiovascular Events Among US Veterans With Chronic Kidney Disease Open

Odeya Barayev, Chelsea E. Hawley, Helen Wellman, Hanna Gerlovin, Whitney Hsu , et al. · 2023

Importance There are limited data for the utility of statins for primary prevention of atherosclerotic cardiovascular disease (ASCVD) and death in adults with chronic kidney disease (CKD). Objective To evaluate the association of statin us…

New statin use, mortality, and first cardiovascular events in older <span>US</span> Veterans by frailty status Open

Ariela R. Orkaby, Bing Lü, Yuk‐Lam Ho, Timothy Treu, Ashley Galloway , et al. · 2023

Background Statins are part of long‐term medical regimens for many older adults. Whether frailty modifies the protective relationship between statins, mortality, and major adverse cardiovascular events (MACE) is unknown. Methods This was a…

Genome‐wide Association Study Meta‐analysis of Neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration Open

Shahzad Ahmad, Mohammed Aslam Imtiaz, Aniket Mishra, Ruiqi Wang, Marisol Herrera-Rivero , et al. · 2023

Background Neurofilament light chain (NfL) levels in circulation have been established as a sensitive biomarker of neuro‐axonal damage across a range of neurodegenerative disorders. Elucidation of the genetic architecture of blood NfL leve…

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