Luc Frimat
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View article: EVATRAN (The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients): study protocol for a cross-over randomized controlled trial
EVATRAN (The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients): study protocol for a cross-over randomized controlled trial Open
View article: Furosemide and the Symptom Burden: The Potential Mediating Role of Uremic Toxins in Patients with CKD
Furosemide and the Symptom Burden: The Potential Mediating Role of Uremic Toxins in Patients with CKD Open
Furosemide appears to contribute to the accumulation of protein-bound uremic toxins (PBUTs) and to induce adverse drug reactions. We investigated the extent to which the association between the furosemide dose and serum PBUT concentrations…
View article: #1453 Changes in nutritional intakes over time and subsequent risk of CKD progression—the CKD-REIN cohort study
#1453 Changes in nutritional intakes over time and subsequent risk of CKD progression—the CKD-REIN cohort study Open
Background and Aims Adequate nutrition is crucial for delaying the progression of chronic kidney disease (CKD). The understanding of adherence to nutritional guidelines in non-dialysis-dependent CKD (NDD-CKD) patients is limited, primarily…
View article: #1676 Association between furosemide and serum uremic toxins levels in patients with chronic kidney disease
#1676 Association between furosemide and serum uremic toxins levels in patients with chronic kidney disease Open
Background and Aims Furosemide is commonly prescribed to patients with CKD but may impair the kidney's excretion of uraemic toxins (UTs) via the organic anion transporters 1 and 3 (OAT1/OAT3). We evaluated the association between furosemid…
View article: #2259 Serum interleukin-8 concentrations, associated factors, and associated cardiovascular risk in patients with moderate-to-advanced chronic kidney disease
#2259 Serum interleukin-8 concentrations, associated factors, and associated cardiovascular risk in patients with moderate-to-advanced chronic kidney disease Open
Background and Aims Chronic kidney disease (CKD) is associated to increased inflammation and elevated cytokine levels. Interleukins, a group of cytokines, play a crucial role in immune system development and activity, serving as key effect…
View article: Heatwaves and plasma sodium disturbances in patients with chronic kidney disease
Heatwaves and plasma sodium disturbances in patients with chronic kidney disease Open
Heatwaves, particularly sustained ones, expose patients with CKD to hyponatremia. Generic recommendations to increase water intake during high temperatures may heighten this risk and are therefore inappropriate for this population. Plasma …
View article: Obinutuzumab, an Anti-CD20, in Refractory Adult Autoimmune Podocytopathies: Report of 2 Cases
Obinutuzumab, an Anti-CD20, in Refractory Adult Autoimmune Podocytopathies: Report of 2 Cases Open
View article: Association of Phenylacetylglutamine and Cognitive Impairment in CKD
Association of Phenylacetylglutamine and Cognitive Impairment in CKD Open
This study shows that a higher serum PAG level was associated with CI in nondialysis-dependent adults with CKD and highlight a new UT associated with CI in patients with CKD. Further studies are needed to confirm the causal nature of the a…
View article: Furosemide and Serum Protein-Bound Uremic Toxin Concentrations in Patients With CKD
Furosemide and Serum Protein-Bound Uremic Toxin Concentrations in Patients With CKD Open
In patients with CKD, furosemide (particularly at a dose level > 120 mg) is independently associated with higher serum free PBUT concentrations. Our findings suggest that drug-UT competition contributes to PBUT accumulation.
View article: Uncovering the Link Between Kynurenic Acid Pathway and Kidney Failure
Uncovering the Link Between Kynurenic Acid Pathway and Kidney Failure Open
View article: Acute kidney injury as a key predictor of cardiovascular events in chronic kidney disease patients: the CKD-REIN study
Acute kidney injury as a key predictor of cardiovascular events in chronic kidney disease patients: the CKD-REIN study Open
Background and Hypothesis Cardiovascular diseases are a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Acute kidney injury (AKI) has been increasingly recognized as a potential exacerbating factor f…
View article: Quantifying the potential contribution of drugs to the occurrence of acute kidney injury in patients with chronic kidney disease
Quantifying the potential contribution of drugs to the occurrence of acute kidney injury in patients with chronic kidney disease Open
Background We sought to comprehensively describe drug-related components associated with acute kidney injury (AKI) in patients with chronic kidney disease (CKD), describing the incidence of drug-related AKI, the proportion of preventable A…
View article: Urea Level and Depression in Patients with Chronic Kidney Disease
Urea Level and Depression in Patients with Chronic Kidney Disease Open
Depression is common in patients with chronic kidney disease (CKD). Experimental studies suggest the role of urea toxicity in depression. We assessed both the incidence of antidepressant prescriptions and depressive symptoms (measured by C…
View article: De-indexed estimated glomerular filtration rates for the dosing of oral antidiabetic drugs in patients with chronic kidney disease
De-indexed estimated glomerular filtration rates for the dosing of oral antidiabetic drugs in patients with chronic kidney disease Open
Introduction: Adjusting drug dose levels based on equations that standardize the estimated glomerular filtration rate (eGFR) to a body surface area (BSA) of 1.73 m 2 can pose challenges, especially for patients with extremely high or low b…
View article: The<scp>EKFC</scp>equation outperforms the<scp>CKD</scp>‐<scp>EPI</scp>and<scp>CKiD</scp>equations for<scp>GFR</scp>estimation in adolescent and young adult kidney transplant patients
The<span>EKFC</span>equation outperforms the<span>CKD</span>‐<span>EPI</span>and<span>CKiD</span>equations for<span>GFR</span>estimation in adolescent and young adult kidney transplant patients Open
Aim This study evaluated the bias and accuracy of the CKD‐EPI/CKiD and EKFC equations compared with the reference exogenous tracer‐based assessment of glomerular filtration rate (GFR) in adult and pediatric patients according to their rena…
View article: #989 Fund and incentivize multidisciplinary CKD care: what can we learn from the French CKD bundled payment program?
#989 Fund and incentivize multidisciplinary CKD care: what can we learn from the French CKD bundled payment program? Open
Background and Aims Multidisciplinary care (MDC) is crucial to slow down the progression of Chronic Kidney Disease (CKD) and prevent or post-pone kidney replacement therapy. To incentivize the development of that care, France launched a na…
View article: #1135 Evaluation of the adequacy of urate lowering therapy prescriptions in patients with chronic kidney disease: results from the CKD-REIN cohort
#1135 Evaluation of the adequacy of urate lowering therapy prescriptions in patients with chronic kidney disease: results from the CKD-REIN cohort Open
Background and Aims Urate Lowering Therapy (ULT) is frequently prescribed to patients with chronic kidney disease (CKD). However, these prescriptions are often inadequate when considering kidney function. Studies evaluating the appropriate…
View article: #2856 Sleep disturbances in non-dialysis dependent chronic kidney disease—The CKD-REIN cohort study
#2856 Sleep disturbances in non-dialysis dependent chronic kidney disease—The CKD-REIN cohort study Open
Background and Aims Sleep disturbances are common in patients on dialysis, but little is known about their prevalence and determinants in earlier chronic kidney disease (CKD) stages. We assessed the prevalence of insomnia, excessive daytim…
View article: #1922 Patterns and 2-year outcomes of preemptive vascular access creation in France
#1922 Patterns and 2-year outcomes of preemptive vascular access creation in France Open
Background and Aims Most studies on clinical practices regarding the type and the timing of vascular access creation are limited to patients on kidney replacement therapy (KRT) from North American settings. Our aim was to describe patterns…
View article: #1091 Quantifying the potential contribution of drugs to the occurrence of acute kidney injury in patients with chronic kidney disease
#1091 Quantifying the potential contribution of drugs to the occurrence of acute kidney injury in patients with chronic kidney disease Open
Background and Aims Patients with CKD have high risk of AKI. Quantifying the contribution of drugs to the occurrence of AKI in this population and assessing its risk factors is important to design preventive interventions. We sought to com…
View article: #2379 Acute kidney injury as a key predictor of major adverse cardiovascular events in chronic kidney disease patients
#2379 Acute kidney injury as a key predictor of major adverse cardiovascular events in chronic kidney disease patients Open
Background and Aims Chronic kidney disease (CKD) significantly raises cardiovascular event risks. The influence of acute-on-chronic kidney incidents is less understood. This study examines the link between acute kidney injury (AKI) episode…
View article: #2437 Association between iron deficiency and risk of major events in chronic kidney disease—CKD-REIN Cohort
#2437 Association between iron deficiency and risk of major events in chronic kidney disease—CKD-REIN Cohort Open
Background and Aims Iron deficiency (ID) is common in patients with chronic kidney disease (CKD) but remains under-diagnosed and its prognosis poorly documented in the absence of anemia. Data from CKDopps showed low TSAT levels were associ…
View article: The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The <scp>CKD‐REIN</scp> cohort study
The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The <span>CKD‐REIN</span> cohort study Open
Aim The risk of cardiorenal events remains high among patients with diabetes and chronic kidney disease (CKD), despite the prescription of recommended treatments. We aimed to determine whether the attainment of a combination of nephroprote…
View article: Long-term changes in cardiac remodelling in prevalent kidney graft recipients
Long-term changes in cardiac remodelling in prevalent kidney graft recipients Open
View article: Quality-of-life measures and their psychometric properties used in African chronic kidney disease populations: a systematic review using COSMIN methodology
Quality-of-life measures and their psychometric properties used in African chronic kidney disease populations: a systematic review using COSMIN methodology Open
View article: Kidney Transplantation After Allogeneic Hematopoietic Cell Transplantation
Kidney Transplantation After Allogeneic Hematopoietic Cell Transplantation Open
View article: Kidney Function Decline and Serious Adverse Drug Reactions in Patients With CKD
Kidney Function Decline and Serious Adverse Drug Reactions in Patients With CKD Open
View article: A new approach for cognitive impairment pattern in chronic kidney disease
A new approach for cognitive impairment pattern in chronic kidney disease Open
Background Chronic kidney disease (CKD) is associated with an elevated risk of neurocognitive disorders (NCDs). It remains unclear whether CKD-related NCDs have a specific cognitive pattern or are earlier-onset phenotypes of the main NCDs …
View article: Evolution of HLA‐sensitization according to immunosuppressive therapy management among kidney transplant patients returning to dialysis between 2008 and 2019: A French retrospective study
Evolution of HLA‐sensitization according to immunosuppressive therapy management among kidney transplant patients returning to dialysis between 2008 and 2019: A French retrospective study Open
Background The optimal management of immunosuppressive therapy (IT) after kidney allograft failure (KAF) remains controversial. Although maintaining IT may reduce HLA‐sensitization and improve access to retransplantation, it may also incre…
View article: Study of the association between serum levels of kynurenine and cardiovascular outcomes and overall mortality in chronic kidney disease
Study of the association between serum levels of kynurenine and cardiovascular outcomes and overall mortality in chronic kidney disease Open
Background Kynurenine is a protein-bound uremic toxin. Its circulating levels are increased in chronic kidney disease (CKD). Experimental studies showed that it exerted deleterious cardiovascular effects. We sought to evaluate an associati…