Luc H. Boudreau
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View article: Inflammatory arthritis is significantly attenuated in alox15 -/- mice 3900
Inflammatory arthritis is significantly attenuated in alox15 -/- mice 3900 Open
Description Rheumatoid arthritis (RA) is a chronic inflammatory disease. 12/15-Lipoxygenase (LO), coded by the alox15 gene, catalyzes the biosynthesis of some lipid mediators of inflammation, however, it’s involvement in pro-inflammatory o…
View article: Creation of a resource for deconvolution of circulating extracellular vesicle (EV) small RNA profiles based on tissue-specific signatures for prediction of response to immunotherapy 2233
Creation of a resource for deconvolution of circulating extracellular vesicle (EV) small RNA profiles based on tissue-specific signatures for prediction of response to immunotherapy 2233 Open
Description Factors that influence response to cancer immunotherapy (IT) are still poorly understood but will be critical in improving patient outcomes. A priori molecular states of immune cells can be important in determining response to …
View article: Platelet-Derived Microvesicles Modulate the Bioenergetic and Inflammatory Phenotype of Human Neutrophils 2192
Platelet-Derived Microvesicles Modulate the Bioenergetic and Inflammatory Phenotype of Human Neutrophils 2192 Open
Description Platelets release microvesicles (PMVs) upon activation which retain platelet cargo, including functional mitochondria, and actively participate in intercellular communication. Neutrophils (PMN) play a vital role in the innate i…
View article: Hippo pathway suppression reprograms TNFα-primed glioblastoma extracellular vesicles transcripts cargo to drive mesenchymal stem/stromal cells vasculogenic mimicry
Hippo pathway suppression reprograms TNFα-primed glioblastoma extracellular vesicles transcripts cargo to drive mesenchymal stem/stromal cells vasculogenic mimicry Open
View article: Defining the role of 12-lipoxygenase in regulating platelet-derived extracellular vesicles
Defining the role of 12-lipoxygenase in regulating platelet-derived extracellular vesicles Open
Platelets are traditionally recognized for their role in hemostasis and wound repair, yet they also play a pivotal role in intercellular communication through the release of platelet-derived extracellular vesicles (PMVs). These vesicles co…
View article: The role of 12-lipoxygenase in regulating megakaryocyte maturation and platelet-like particles production
The role of 12-lipoxygenase in regulating megakaryocyte maturation and platelet-like particles production Open
View article: Platelet-derived microvesicles modulate the bioenergetic and inflammatory phenotype of human polymorphonuclear leukocytes
Platelet-derived microvesicles modulate the bioenergetic and inflammatory phenotype of human polymorphonuclear leukocytes Open
Platelets release microvesicles (PMVs) into the extracellular milieu upon activation. PMVs retain various platelet components, including functional mitochondria, and actively participate in intercellular communication with immune cells suc…
View article: Supplementary Video 2B from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 2B from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 2B displays the intracellular localization of internalized fluorescent mitochondria provided by microparticles in MCF7 cells using 3D confocal zStacks imaging.
View article: Supplementary Video 2A from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 2A from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 2A displays the intracellular localization of internalized fluorescent mitochondria provided by microparticles in MB231 cells using 3D confocal zStacks imaging.
View article: Supplementary Video 1A from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 1A from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 1A displays the intracellular localization of internalized fluorescent microparticles in MB231 cells using 3D confocal zStacks imaging.
View article: Supplementary Video 1C from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 1C from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 1C displays the intracellular localization of internalized fluorescent microparticles in MCF10A cells using 3D confocal zStacks imaging.
View article: Supplementary Figure 3 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 3 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S3 validates the findings of Fig.S2 by demonstrating the intracellular localization of fluorescent microparticles using confocal microscopy.
View article: Supplementary Video 1B from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 1B from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 1B displays the intracellular localization of internalized fluorescent microparticles in MCF7 cells using 3D confocal zStacks imaging.
View article: Supplementary Figure 6 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 6 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S6 demonstrates the impact of microparticle freezing treatments have on mitochondrial function. Frozen microparticles have complete disruption of mitochondrial activities.
View article: Supplementary Figure 2 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 2 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S2 demonstrates that the fluorescent microparticles do not simply interact bing the recipients' cell surface, but are internalized in the intracellular compartment. This is demonstrated by digestion of the cell surface receptors/lig…
View article: Supplementary Figure 1 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 1 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S1 displays the capacity of fluorescent microparticles to interact with cancer cells. Using flow cytometry, we measure fluorescence uptake by cells following cell co-cultures with microparticles.
View article: Supplementary Video 2C from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 2C from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 2C displays the intracellular localization of internalized fluorescent mitochondria provided by microparticles in MCF10A cells using 3D confocal zStacks imaging.
View article: Supplementary Video 1C from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 1C from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 1C displays the intracellular localization of internalized fluorescent microparticles in MCF10A cells using 3D confocal zStacks imaging.
View article: Supplementary Figure 5 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 5 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S5 shows the effects of microparticles on the migration and invasion capacities of non-cancerous control cell line MCF10A.
View article: Supplementary Video 1B from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 1B from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 1B displays the intracellular localization of internalized fluorescent microparticles in MCF7 cells using 3D confocal zStacks imaging.
View article: Data from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Data from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
An increasing number of studies show that platelets as well as platelet-derived microparticles (PMP) play significant roles in cancer malignancy and disease progression. Particularly, PMPs have the capacity to interact and internalize with…
View article: Supplementary Figure 5 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 5 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S5 shows the effects of microparticles on the migration and invasion capacities of non-cancerous control cell line MCF10A.
View article: Supplementary Figure 3 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 3 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S3 validates the findings of Fig.S2 by demonstrating the intracellular localization of fluorescent microparticles using confocal microscopy.
View article: Supplementary Video 2B from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 2B from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 2B displays the intracellular localization of internalized fluorescent mitochondria provided by microparticles in MCF7 cells using 3D confocal zStacks imaging.
View article: Supplementary Video 2C from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 2C from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 2C displays the intracellular localization of internalized fluorescent mitochondria provided by microparticles in MCF10A cells using 3D confocal zStacks imaging.
View article: Supplementary Video 1A from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 1A from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 1A displays the intracellular localization of internalized fluorescent microparticles in MB231 cells using 3D confocal zStacks imaging.
View article: Supplementary Figure 1 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 1 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S1 displays the capacity of fluorescent microparticles to interact with cancer cells. Using flow cytometry, we measure fluorescence uptake by cells following cell co-cultures with microparticles.
View article: Supplementary Video 2A from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Video 2A from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Supplementary Video 2A displays the intracellular localization of internalized fluorescent mitochondria provided by microparticles in MB231 cells using 3D confocal zStacks imaging.
View article: Supplementary Figure 6 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 6 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S6 demonstrates the impact of microparticle freezing treatments have on mitochondrial function. Frozen microparticles have complete disruption of mitochondrial activities.
View article: Supplementary Figure 4 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Supplementary Figure 4 from Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features Open
Figure S4 demonstrates that microparticles contain mitochondria cargo using PCR to detect mitochondrial DNA.