Luc J. W. Evers
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View article: Wearable tracking of walking and non-walking as progression markers in early Parkinson’s disease
Wearable tracking of walking and non-walking as progression markers in early Parkinson’s disease Open
IMPORTANCE Wearable-based measures of walking (as proxy for physical activity) may quantify disease progression and modification thereof in early-stage Parkinson’s disease (PD). OBJECTIVES Establishing the validity of digital measures of w…
View article: Heart rate monitoring using wrist photoplethysmography in Parkinson disease: feasibility and relation with autonomic dysfunction
Heart rate monitoring using wrist photoplethysmography in Parkinson disease: feasibility and relation with autonomic dysfunction Open
Background Cardiac autonomic dysfunction is a prevalent yet underdiagnosed non-motor manifestation in Parkinson disease (PD), and difficult to monitor in daily life. Wrist-worn photoplethysmography (PPG) allows for continuous pulse rate mo…
View article: Heart Rate Profiles During Exercise and Incident Parkinson's Disease
Heart Rate Profiles During Exercise and Incident Parkinson's Disease Open
Objective To determine whether established heart rate parameters of exercise, related to cardiac autonomic function, are associated with incident Parkinson's disease, independent of both clinical and autonomic prodromal features. Methods A…
View article: Advancing the Integration of Digital Health Technologies in the Drug Development Ecosystem
Advancing the Integration of Digital Health Technologies in the Drug Development Ecosystem Open
Optimized frameworks for efficient and scalable deployment of digital health technologies (DHT) are needed to address existing bottlenecks and unlock the opportunities for remote monitoring and operationalizing decentralized trials. DHTs o…
View article: A generalizable and open-source algorithm for real-life monitoring of tremor in Parkinson’s disease
A generalizable and open-source algorithm for real-life monitoring of tremor in Parkinson’s disease Open
Wearable sensors can objectively and continuously monitor daily-life tremor in Parkinson’s Disease (PD). We developed an open-source algorithm for real-life monitoring of PD tremor which achieves generalizable performance across different …
View article: Interpretable and Granular Video-Based Quantification of Motor Characteristics from the Finger Tapping Test in Parkinson Disease
Interpretable and Granular Video-Based Quantification of Motor Characteristics from the Finger Tapping Test in Parkinson Disease Open
Accurately quantifying motor characteristics in Parkinson disease (PD) is crucial for monitoring disease progression and optimizing treatment strategies. The finger-tapping test is a standard motor assessment. Clinicians visually evaluate …
View article: Cardiorespiratory Response to Exercise in Parkinson's Disease: Associations with Autonomic Dysfunction and Physical Activity
Cardiorespiratory Response to Exercise in Parkinson's Disease: Associations with Autonomic Dysfunction and Physical Activity Open
Background Both autonomic dysfunction and low levels of physical activity could contribute to reduced cardiorespiratory fitness in people with Parkinson's disease (PD). However, the interrelationship between these concepts is not well unde…
View article: Conversational Agents Supporting Self-Management in People With a Chronic Disease: Systematic Review
Conversational Agents Supporting Self-Management in People With a Chronic Disease: Systematic Review Open
Background Conversational agents (CAs) are increasingly used as a promising tool for scalable, accessible, and personalized self-management support of people with a chronic disease. Studies of CAs for self-management of chronic disease ope…
View article: Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait
Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait Open
Background Accurately measuring hypokinetic arm swing during free-living gait in Parkinson’s disease (PD) is challenging due to other concurrent arm activities. We developed a method to isolate gait segments without these arm activities. M…
View article: Passive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach
Passive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach Open
Objective and continuous monitoring of Parkinson’s disease (PD) tremor in free-living conditions could benefit both individual patient care and clinical trials, by overcoming the snapshot nature of clinical assessments. To enable robust de…
View article: Cardiac autonomic function during exercise and incident Parkinson’s disease
Cardiac autonomic function during exercise and incident Parkinson’s disease Open
Objective To determine whether established parameters of cardiac autonomic function are associated with incident Parkinson’s disease, independent of clinical characteristics, and established autonomic prodromal features. Methods Population…
View article: Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art
Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art Open
Digital biomarkers that remotely monitor symptoms have the potential to revolutionize outcome assessments in future disease-modifying trials in Parkinson’s disease (PD), by allowing objective and recurrent measurement of symptoms and signs…
View article: Usability and utility of a remote monitoring system to support physiotherapy for people with Parkinson's disease
Usability and utility of a remote monitoring system to support physiotherapy for people with Parkinson's disease Open
Background Physiotherapy for persons with Parkinson's disease (PwPD) could benefit from objective and continuous tracking of physical activity and falls in daily life. Objectives We designed a remote monitoring system for this purpose and …
View article: Need for personalized monitoring of Parkinson’s disease: the perspectives of patients and specialized healthcare providers
Need for personalized monitoring of Parkinson’s disease: the perspectives of patients and specialized healthcare providers Open
Background Digital tools such as wearable sensors may help to monitor Parkinson’s disease (PD) in daily life. To optimally achieve the expected benefits, such as personized care and improved self-management, it is essential to understand t…
View article: The effect of cardiovascular risk on disease progression in de novo Parkinson's disease patients: An observational analysis
The effect of cardiovascular risk on disease progression in de novo Parkinson's disease patients: An observational analysis Open
Background Currently available treatment options for Parkinson's disease are symptomatic and do not alter the course of the disease. Recent studies have raised the possibility that cardiovascular risk management may slow the progression of…
View article: Developing better digital health measures of Parkinson’s disease using free living data and a crowdsourced data analysis challenge
Developing better digital health measures of Parkinson’s disease using free living data and a crowdsourced data analysis challenge Open
One of the promising opportunities of digital health is its potential to lead to more holistic understandings of diseases by interacting with the daily life of patients and through the collection of large amounts of real-world data. Valida…
View article: Time trends in demographic characteristics of participants and outcome measures in Parkinson’s disease research: A 19-year single-center experience
Time trends in demographic characteristics of participants and outcome measures in Parkinson’s disease research: A 19-year single-center experience Open
View article: Author Correction: Virtual exam for Parkinson’s disease enables frequent and reliable remote measurements of motor function
Author Correction: Virtual exam for Parkinson’s disease enables frequent and reliable remote measurements of motor function Open
View article: TSDF: A simple yet comprehensive, unified data storage and exchange format standard for digital biosensor data in health applications
TSDF: A simple yet comprehensive, unified data storage and exchange format standard for digital biosensor data in health applications Open
Digital sensors are increasingly being used to monitor the change over time of physiological processes in biological health and disease, often using wearable devices. This generates very large amounts of digital sensor data, for which, a c…
View article: Identifying and characterising sources of variability in digital outcome measures in Parkinson’s disease
Identifying and characterising sources of variability in digital outcome measures in Parkinson’s disease Open
View article: Virtual exam for Parkinson’s disease enables frequent and reliable remote measurements of motor function
Virtual exam for Parkinson’s disease enables frequent and reliable remote measurements of motor function Open
View article: Virtual Exam for Parkinson’s Disease Enables Frequent and Reliable Remote Measurements of Motor Function
Virtual Exam for Parkinson’s Disease Enables Frequent and Reliable Remote Measurements of Motor Function Open
Sensor-based remote monitoring could help us better track Parkinson’s disease (PD) progression, and measure patients’ response to putative disease-modifying therapeutic interventions. To be useful, the remotely-collected measurements shoul…
View article: Rapid Dynamic Naturalistic Monitoring of Bradykinesia in Parkinson’s Disease Using a Wrist-Worn Accelerometer
Rapid Dynamic Naturalistic Monitoring of Bradykinesia in Parkinson’s Disease Using a Wrist-Worn Accelerometer Open
Motor fluctuations in Parkinson’s disease are characterized by unpredictability in the timing and duration of dopaminergic therapeutic benefits on symptoms, including bradykinesia and rigidity. These fluctuations significantly impair the q…
View article: Developing better digital health measures of Parkinson’s disease using free living data and a crowdsourced data analysis challenge
Developing better digital health measures of Parkinson’s disease using free living data and a crowdsourced data analysis challenge Open
One of the promising opportunities of digital health is its potential to lead to more holistic understandings of diseases by interacting with the daily life of patients and through the collection of large amounts of real world data. Valida…
View article: Rapid dynamic naturalistic monitoring of bradykinesia in Parkinson’s disease using a wrist-worn accelerometer
Rapid dynamic naturalistic monitoring of bradykinesia in Parkinson’s disease using a wrist-worn accelerometer Open
Introduction Motor fluctuations in Parkinson’s disease are characterized by unpredictability in the timing and duration of dopaminergic therapeutic benefit on symptoms including bradykinesia and rigidity. These fluctuations significantly i…
View article: The state of telemedicine for persons with Parkinson's disease
The state of telemedicine for persons with Parkinson's disease Open
Purpose of review The COVID-pandemic has facilitated the implementation of telemedicine in both clinical practice and research. We highlight recent developments in three promising areas of telemedicine: teleconsultation, telemonitoring, an…
View article: Precompetitive Consensus Building to Facilitate the Use of Digital Health Technologies to Support Parkinson Disease Drug Development through Regulatory Science
Precompetitive Consensus Building to Facilitate the Use of Digital Health Technologies to Support Parkinson Disease Drug Development through Regulatory Science Open
Innovative tools are urgently needed to accelerate the evaluation and subsequent approval of novel treatments that may slow, halt, or reverse the relentless progression of Parkinson disease (PD). Therapies that intervene early in the disea…
View article: Probabilistic Modelling of Gait for Robust Passive Monitoring in Daily Life
Probabilistic Modelling of Gait for Robust Passive Monitoring in Daily Life Open
Passive monitoring in daily life may provide invaluable insights about a person's health throughout the day. Wearable sensor devices are likely to play a key role in enabling such monitoring in a non-obtrusive fashion. However, sensor data…
View article: Estimating the Effect of Early Treatment Initiation in Parkinson's Disease Using Observational Data
Estimating the Effect of Early Treatment Initiation in Parkinson's Disease Using Observational Data Open
Background Both patients and physicians may choose to delay initiation of dopamine replacement therapy in Parkinson's disease (PD) for various reasons. We used observational data to estimate the effect of earlier treatment in PD. Observati…
View article: Real-Life Gait Performance as a Digital Biomarker for Motor Fluctuations: The Parkinson@Home Validation Study
Real-Life Gait Performance as a Digital Biomarker for Motor Fluctuations: The Parkinson@Home Validation Study Open
Background Wearable sensors have been used successfully to characterize bradykinetic gait in patients with Parkinson disease (PD), but most studies to date have been conducted in highly controlled laboratory environments. Objective This pa…