Luc Mallet
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View article: Neuromodulation techniques in obsessive-compulsive disorder: Current state of the art
Neuromodulation techniques in obsessive-compulsive disorder: Current state of the art Open
Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric condition often resistant to conventional treatments such as cognitive behavioral therapy and pharmacotherapy. For treatment-refractory cases, neuromodulation techniques off…
View article: Stability-Guided Formulation of a Light-Sensitive D-LSD Capsule for Clinical Investigation
Stability-Guided Formulation of a Light-Sensitive D-LSD Capsule for Clinical Investigation Open
Background/Objectives: D-lysergic acid diethylamide (D-LSD) is under investigation as a potential therapeutic strategy for alcohol use disorder (AUD). However, the extreme light sensitivity of D-LSD presents a significant challenge in deve…
View article: Transcranial direct current stimulation in patients with depression: An electric field modeling meta-analysis
Transcranial direct current stimulation in patients with depression: An electric field modeling meta-analysis Open
Transcranial Direct Current Stimulation (tDCS) has shown potential in modulating cortical activity and treating depression. Despite its promise, variability in electrode montage configurations and electric field strength across studies has…
View article: Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies
Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies Open
View article: Serotonergic underpinnings of obsessive‐compulsive disorder: A systematic review and meta‐analysis of neuroimaging findings
Serotonergic underpinnings of obsessive‐compulsive disorder: A systematic review and meta‐analysis of neuroimaging findings Open
Obsessive‐compulsive disorder (OCD) is a frequent and disabling condition, with many patients being treatment‐resistant. Improved understanding of its neurobiology is vital for better therapies. Evidence is still conflicting regarding spec…
View article: Pallidal neuronal activity in Gilles de la Tourette syndrome and dystonic patients: A comparative study
Pallidal neuronal activity in Gilles de la Tourette syndrome and dystonic patients: A comparative study Open
Gilles de la Tourette syndrome (GTS) and dystonia (DYS) are both hyperkinetic movement disorders effectively treated by deep brain stimulation (DBS) of the internal part of the globus pallidus (GPi). In this study, we compared single‐neuro…
View article: Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial
Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial Open
Background A significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the development of new alternatives. In parallel, psilocybin-assisted therapy for alcohol use d…
View article: Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder: Protocol for a Double-Blind, Randomized, Placebo-Controlled, 7-month Parallel-Group Phase II Superiority Trial
Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder: Protocol for a Double-Blind, Randomized, Placebo-Controlled, 7-month Parallel-Group Phase II Superiority Trial Open
Background: A significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the development of new alternatives. In parallel, psilocybin-assisted therapy for alcohol use …
View article: Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey
Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey Open
View article: Psilocybin-assisted therapy for depression: A systematic review and dose-response meta-analysis of human studies
Psilocybin-assisted therapy for depression: A systematic review and dose-response meta-analysis of human studies Open
Psilocybin is increasingly studied for its antidepressant effect, but its optimal dosage for depression remains unclear. We conducted a systematic review and a dose-response meta-analysis to find the optimal dosage of psilocybin to reduce …
View article: A century of research on neuromodulation interventions: A scientometric analysis of trends and knowledge maps
A century of research on neuromodulation interventions: A scientometric analysis of trends and knowledge maps Open
Interest in neurostimulation interventions has significantly grown in recent decades, yet a scientometric analysis objectively mapping scientific knowledge and recent trends remains unpublished. Using relevant keywords, we conducted a sear…
View article: Psychiatric consequences and issues of long COVID on patients with prior psychiatric comorbidities: a scoping review
Psychiatric consequences and issues of long COVID on patients with prior psychiatric comorbidities: a scoping review Open
SARS-CoV-2 is a growing field of research and mental health in long COVID is one of its interesting domains. This scoping review aims at studying the outcomes of mental health in patients already known for psychiatric illness. This was don…
View article: A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment
A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment Open
Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The invest…
View article: Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients
Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients Open
Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30–40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacolo…
View article: The Sapap3−/− mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours
The Sapap3−/− mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours Open
Symptom comorbidity is present amongst neuropsychiatric disorders with repetitive behaviours, complicating clinical diagnosis and impeding appropriate treatments. This is of particular importance for obsessive-compulsive disorder (OCD) and…
View article: No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease
No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease Open
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a powerful treatment in Parkinson’s disease (PD), which provides a positive effect on motor symptoms although the way it operates on high cognitive processes such as metacognit…
View article: Neurobiology of obsessive-compulsive disorder: an fMRI study of checking compulsions
Neurobiology of obsessive-compulsive disorder: an fMRI study of checking compulsions Open
View article: A century of research on psychedelics: A scientometric analysis on trends and knowledge maps of hallucinogens, entactogens, entheogens and dissociative drugs
A century of research on psychedelics: A scientometric analysis on trends and knowledge maps of hallucinogens, entactogens, entheogens and dissociative drugs Open
A scientometric analysis was realized to outline clinical research on psychedelics over the last century. Web of Science Core Collection was searched up to March 18, 2022, for publications on psychedelics. Network analyses and bibliometric…
View article: Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?
Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype? Open
View article: Joint contributions of metacognition and self-beliefs to uncertainty-guided checking behavior
Joint contributions of metacognition and self-beliefs to uncertainty-guided checking behavior Open
View article: Identification of biomarkers that predict response to subthalamic nucleus deep brain stimulation in resistant obsessive–compulsive disorder: protocol for an open-label follow-up study
Identification of biomarkers that predict response to subthalamic nucleus deep brain stimulation in resistant obsessive–compulsive disorder: protocol for an open-label follow-up study Open
Introduction Deep brain stimulation (DBS) of bilateral anteromedial subthalamic nucleus (amSTN) has been found to be helpful in a subset of patients with severe, chronic and treatment-refractory obsessive–compulsive disorder (OCD). Biomark…
View article: A cross-species assessment of behavioral flexibility in compulsive disorders
A cross-species assessment of behavioral flexibility in compulsive disorders Open
View article: The Sapap3-knockout mouse model manifests a spectrum of repetitive behaviours
The Sapap3-knockout mouse model manifests a spectrum of repetitive behaviours Open
Symptom comorbidity is present amongst neuropsychiatric disorders with repetitive behaviors, complicating clinical diagnosis and impeding appropriate subsequent treatments. This is of particular importance for Obsessive-Compulsive Disorder…
View article: Deep brain stimulation of the subthalamic nucleus in obsessive–compulsives disorders: long-term follow-up of an open, prospective, observational cohort
Deep brain stimulation of the subthalamic nucleus in obsessive–compulsives disorders: long-term follow-up of an open, prospective, observational cohort Open
Background Obsessive–compulsive disorder (OCD) is a major cause of disability in western country and responsible for severe impairment of quality of life. About 10% of patients present with severe OCD symptoms and require innovative treatm…
View article: Deep Brain Stimulation of the Subthalamic, Accumbens, or Caudate Nuclei for Patients With Severe Obsessive-Compulsive Disorder: A Randomized Crossover Controlled Study
Deep Brain Stimulation of the Subthalamic, Accumbens, or Caudate Nuclei for Patients With Severe Obsessive-Compulsive Disorder: A Randomized Crossover Controlled Study Open
View article: I can’t get it off my mind: Attentional bias in former and current cocaine addiction
I can’t get it off my mind: Attentional bias in former and current cocaine addiction Open
Background: Cocaine addiction is a global health issue with limited therapeutic options and a high relapse rate. Attentional bias towards substance-related cues may be an important factor for relapse. However, it has never been compared in…
View article: Emotions Modulate Subthalamic Nucleus Activity: New Evidence in Obsessive-Compulsive Disorder and Parkinson’s Disease Patients
Emotions Modulate Subthalamic Nucleus Activity: New Evidence in Obsessive-Compulsive Disorder and Parkinson’s Disease Patients Open
View article: New Oxford Textbook of Psychiatry
New Oxford Textbook of Psychiatry Open
The third edition of the textbook presents psychiatry as a medical specialty. The application of science has transformed much of medicine by providing an understanding of the mechanisms of pathology. The genetic basis of psychiatry guarant…
View article: Personalised 360o video exposure therapy for the treatment of obsessive-compulsive disorder: A single case study
Personalised 360o video exposure therapy for the treatment of obsessive-compulsive disorder: A single case study Open
View article: Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviors
Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviors Open
Symptom comorbidity is present amongst neuropsychiatric disorders with repetitive behaviours, complicating clinical diagnosis and impeding appropriate treatments. This is of particular importance for obsessive-compulsive disorder (OCD) and…