Luca Arecco
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View article: Managing relapses during or after adjuvant CDK4/6 inhibitors in HR-positive/HER2-negative early breast cancer: an emerging challenge
Managing relapses during or after adjuvant CDK4/6 inhibitors in HR-positive/HER2-negative early breast cancer: an emerging challenge Open
View article: Early breast cancer in young <i>BRCA</i> carriers: from diagnosis to treatment and survivorship
Early breast cancer in young <i>BRCA</i> carriers: from diagnosis to treatment and survivorship Open
Breast cancer is the most frequent malignancy among young women, with unique challenges particularly for carriers of BRCA pathogenic or likely pathogenic variants (PVs). Among them, the indication for intensive surveillance and risk-reduci…
View article: Neoadjuvant immune-modulating SBRT and anti-CD73 to increase response to anti-PD-L1 and chemotherapy in early ER+/HER2- breast cancer: primary endpoint and translational results from the randomized Neo-CheckRay trial
Neoadjuvant immune-modulating SBRT and anti-CD73 to increase response to anti-PD-L1 and chemotherapy in early ER+/HER2- breast cancer: primary endpoint and translational results from the randomized Neo-CheckRay trial Open
Patients with oestrogen receptor-positive (ER+), HER2-negative, early breast cancer (BC) have low pathological complete response (pCR) rates following neoadjuvant chemotherapy (NACT). Phase 3 trials showed that adding an anti-PD-1 immune c…
View article: Safety of having a subsequent pregnancy after prior diagnosis of breast cancer during pregnancy in young BRCA carriers
Safety of having a subsequent pregnancy after prior diagnosis of breast cancer during pregnancy in young BRCA carriers Open
View article: PREDICTIVE BRCA GENETIC TESTING IN ITALIAN PATIENTS WITH BREAST CANCER: A POSITION PAPER OF ITALIAN SCIENTIFIC SOCIETIES [Italian Association of Medical Oncology(AIOM); Italian Association of Radiotherapy and Clinical Oncology (AIRO); Italian National Association of Breast Surgeons (ANISC); Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP); Italian Society of Surgical Oncology (SICO); Italian Society of Human Genetic (SIGU); Italian Society of General Practice (SIMG); Italian Society of Medical and Interventional Radiology (SIRM)]
PREDICTIVE BRCA GENETIC TESTING IN ITALIAN PATIENTS WITH BREAST CANCER: A POSITION PAPER OF ITALIAN SCIENTIFIC SOCIETIES [Italian Association of Medical Oncology(AIOM); Italian Association of Radiotherapy and Clinical Oncology (AIRO); Italian National Association of Breast Surgeons (ANISC); Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP); Italian Society of Surgical Oncology (SICO); Italian Society of Human Genetic (SIGU); Italian Society of General Practice (SIMG); Italian Society of Medical and Interventional Radiology (SIRM)] Open
View article: Gonadotoxicity of immunotherapy and targeted agents in patients with cancer and impact on subsequent pregnancies
Gonadotoxicity of immunotherapy and targeted agents in patients with cancer and impact on subsequent pregnancies Open
In recent years, cancer treatment has been revolutionized by the introduction of many novel drugs, including immunotherapy and targeted agents, which have significantly improved the prognosis of patients with different solid tumors. While …
View article: Cardiovascular toxicity of breast cancer treatments: from understanding to enhancing survivorship care
Cardiovascular toxicity of breast cancer treatments: from understanding to enhancing survivorship care Open
View article: 269P Association of alcohol consumption on breast cancer incidence and prognosis: A systematic review and meta-analysis
269P Association of alcohol consumption on breast cancer incidence and prognosis: A systematic review and meta-analysis Open
View article: 420P Physicians’ knowledge, practice and attitudes on fertility and pregnancy-related issues in young women with advanced breast cancer: Results of the ABC6 and ABC7 survey
420P Physicians’ knowledge, practice and attitudes on fertility and pregnancy-related issues in young women with advanced breast cancer: Results of the ABC6 and ABC7 survey Open
View article: 277P Body mass index (BMI) and breast cancer (BC) risk according to subtypes: A systematic review and meta-analysis
277P Body mass index (BMI) and breast cancer (BC) risk according to subtypes: A systematic review and meta-analysis Open
View article: Physicians’ knowledge, practice, and attitudes on fertility and pregnancy-related issues in young women with advanced breast cancer: results of the ABC6 and ABC7 survey
Physicians’ knowledge, practice, and attitudes on fertility and pregnancy-related issues in young women with advanced breast cancer: results of the ABC6 and ABC7 survey Open
Our survey showed that many concerns exist when discussing and dealing with fertility and pregnancy-related issues in patients with advanced breast cancer. It is essential to increase physicians' awareness on how to address fertility and p…
View article: Extended adjuvant endocrine therapy in early breast cancer: finding the individual balance
Extended adjuvant endocrine therapy in early breast cancer: finding the individual balance Open
Endocrine therapy (ET) is a cornerstone in the management of patients with hormone receptor-positive early breast cancer, which accounts for over 70% of cases worldwide. The efficacy of adjuvant ET for 5 years in reducing the risk of recur…
View article: Adverse events and impact on quality of life of antibody‐drug conjugates in the treatment of metastatic breast cancer: A systematic review and meta‐analysis
Adverse events and impact on quality of life of antibody‐drug conjugates in the treatment of metastatic breast cancer: A systematic review and meta‐analysis Open
Background Antibody‐drug conjugates are novel effective therapies for metastatic breast cancer. Nevertheless, their toxicity profile can significantly affect patients' quality of life over time. Methods This is a systematic review and meta…
View article: Treatments of Interest in Male Breast Cancer: An Umbrella Review
Treatments of Interest in Male Breast Cancer: An Umbrella Review Open
Background: Male breast cancer (MaBC) is a rare disease and due to its rarity and the lack of specific protocols for its management, treatment algorithms are extrapolated from female breast cancer (FBC). To optimize MaBC treatment, we conc…
View article: Prognostic implications of risk definitions from the monarchE and NATALEE trials
Prognostic implications of risk definitions from the monarchE and NATALEE trials Open
Background The monarchE and NATALEE trials employed different high-risk inclusion criteria. The main objective is to assess prognostic differences based on their inclusion criteria. Methods Patients with hormone receptor-positive/HER2-nega…
View article: Comparison of Suboptimal Versus Adequate Ovarian Function Suppression in Premenopausal Women with Early Breast Cancer Treated with Adjuvant Endocrine Therapy: An Exploratory Analysis of Two Prospective Studies
Comparison of Suboptimal Versus Adequate Ovarian Function Suppression in Premenopausal Women with Early Breast Cancer Treated with Adjuvant Endocrine Therapy: An Exploratory Analysis of Two Prospective Studies Open
View article: Physicians’ Knowledge, Practice, and Attitudes on Fertility and Pregnancy-Related Issues in Young Women with Advanced Breast Cancer: Results of the Abc6 and Abc7 Survey
Physicians’ Knowledge, Practice, and Attitudes on Fertility and Pregnancy-Related Issues in Young Women with Advanced Breast Cancer: Results of the Abc6 and Abc7 Survey Open
View article: Practices and views about palliative care at the end of life: A survey of oncologists from the Italian region of Liguria
Practices and views about palliative care at the end of life: A survey of oncologists from the Italian region of Liguria Open
Introduction: We conducted an online survey to investigate oncologists' clinical practices and views on palliative care at the end of life in the Italian region of Liguria. Methods: The survey included 29 items divided into three sections:…
View article: Follow-up of early breast cancer in a public health system: A 2024 AIGOM consensus project
Follow-up of early breast cancer in a public health system: A 2024 AIGOM consensus project Open
View article: Adjuvant endocrine therapy choices in premenopausal patients with hormone receptor-positive early breast cancer: Insights from the prospective GIM23-POSTER study
Adjuvant endocrine therapy choices in premenopausal patients with hormone receptor-positive early breast cancer: Insights from the prospective GIM23-POSTER study Open
View article: Impact of hormone receptor status and tumor subtypes of breast cancer in young BRCA carriers
Impact of hormone receptor status and tumor subtypes of breast cancer in young BRCA carriers Open
In young BRCA carriers, differences in recurrence pattern and second primary breast cancer among hormone receptor-positive versus negative disease warrant consideration in counseling patients on treatment, follow-up, and risk-reducing surg…
View article: Patterns of care at the end of life: a retrospective study of Italian patients with advanced breast cancer
Patterns of care at the end of life: a retrospective study of Italian patients with advanced breast cancer Open
Objectives To better understand the type of care offered to Italian patients with advanced breast cancer at the End-of-Life (EoL), we conducted a retrospective observational study. EoL was defined as the period of six months before death. …
View article: 154P Validation of PREDICT tool version 2.2 in early-stage breast cancer (BC) patients enrolled in adjuvant trials by the Gruppo Italiano Mammella (GIM) and Mammella Intergruppo (MIG)
154P Validation of PREDICT tool version 2.2 in early-stage breast cancer (BC) patients enrolled in adjuvant trials by the Gruppo Italiano Mammella (GIM) and Mammella Intergruppo (MIG) Open
PREDICT, an online prognostic tool developed from population registries, estimates the potential benefit of different treatments (i.e., surgery alone, chemotherapy, trastuzumab, endocrine therapy, and/or bisphosphonates) for early-stage BC…
View article: 290P Adverse events (AEs) and impact on quality of life (QoL) of antibody-drug conjugates (ADC) in the treatment of metastatic breast cancer (mBC): A systematic review and meta-analysis of randomized controlled trials (RCTs)
290P Adverse events (AEs) and impact on quality of life (QoL) of antibody-drug conjugates (ADC) in the treatment of metastatic breast cancer (mBC): A systematic review and meta-analysis of randomized controlled trials (RCTs) Open
ADCs are a novel effective therapy for BC. Several RCTs compared ADCs vs therapy of physician's choice (TPC) showing impressive efficacy and leading to their accelerated approval. However, ADCs' toxicity profile can significantly affect pa…
View article: 125P Suboptimal ovarian suppression during adjuvant endocrine therapy for premenopausal women with breast cancer: An exploratory analysis of the PREFER and GIM 23 studies
125P Suboptimal ovarian suppression during adjuvant endocrine therapy for premenopausal women with breast cancer: An exploratory analysis of the PREFER and GIM 23 studies Open
Adjuvant endocrine therapy (ET) with exemestane combined with LHRH analog (LHRHa) is standard of care for premenopausal women with hormone receptor-positive breast cancer. However, LHRHa may not always achieve complete ovarian suppression …
View article: Intermediate clinical endpoints in early-stage breast cancer: an analysis of individual patient data from the Gruppo Italiano Mammella and Mammella Intergruppo trials
Intermediate clinical endpoints in early-stage breast cancer: an analysis of individual patient data from the Gruppo Italiano Mammella and Mammella Intergruppo trials Open
View article: The treatment of advanced melanoma: Current approaches and new challenges
The treatment of advanced melanoma: Current approaches and new challenges Open
In recent years, advances in melanoma treatment have renewed patient hope. This comprehensive review emphasizes the evolving treatment landscape, particularly highlighting first-line strategies and the interplay between immune-checkpoint i…
View article: Impact of Hormone Receptor Status and Tumor Subtypes on Clinical Behavior and Outcomes of Breast Cancer in Young&nbsp;BRCA&nbsp;Carriers
Impact of Hormone Receptor Status and Tumor Subtypes on Clinical Behavior and Outcomes of Breast Cancer in Young BRCA Carriers Open
View article: Fertility and Pregnancy-Related Issues in Young <i>BRCA</i> Carriers With Breast Cancer
Fertility and Pregnancy-Related Issues in Young <i>BRCA</i> Carriers With Breast Cancer Open
Approximately 10% to 15% of breast cancer cases in young women are diagnosed in patients harbouring germline (g) pathogenic or likely pathogenic variants (PVs) in the BReast CAncer 1 ( BRCA1) or BReast CAncer 2 ( BRCA2) genes. Preclinical …
View article: Adjuvant Endocrine Therapy Choices in Premenopausal Patients with Hormone Receptor-Positive Early Breast Cancer: Results from the Prospective Gim23-Poster Study
Adjuvant Endocrine Therapy Choices in Premenopausal Patients with Hormone Receptor-Positive Early Breast Cancer: Results from the Prospective Gim23-Poster Study Open