Luca Bosco
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View article: Novel therapies for myasthenia gravis: Translational research from animal models to clinical application
Novel therapies for myasthenia gravis: Translational research from animal models to clinical application Open
Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting…
View article: Muscle hypertrophy following acquired neurogenic injury: systematic review and analysis of existing literature
Muscle hypertrophy following acquired neurogenic injury: systematic review and analysis of existing literature Open
Objectives Neurogenic muscle hypertrophy (NMH) is a rare condition characterized by focal muscle hypertrophy caused by chronic partial nervous injury. Given its infrequency, underlying mechanisms remain poorly understood. Inspired by two c…
View article: Overcoming therapeutic challenges: Successful management of a supposedly triple seronegative, refractory generalized myasthenia gravis patient with efgartigimod
Overcoming therapeutic challenges: Successful management of a supposedly triple seronegative, refractory generalized myasthenia gravis patient with efgartigimod Open
Background and purpose This study was undertaken to highlight neonatal Fc receptor inhibition (efgartigimod) as a valuable therapeutic option for patients with refractory seronegative myasthenia gravis (MG) and to emphasize the concept tha…
View article: Reassessing the efficacy of bevacizumab in newly diagnosed glioblastoma: A systematic review and external pseudodata-based analysis
Reassessing the efficacy of bevacizumab in newly diagnosed glioblastoma: A systematic review and external pseudodata-based analysis Open
Background First-line use of bevacizumab for glioblastoma (GBM) was evaluated in 2 phase 3 randomized controlled trials (RCT), demonstrating an impact on progression-free survival but not overall survival (OS). However, the crossover event…
View article: Corrigendum to “Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs” [Heliyon 9(4) (April 2023) e15047]
Corrigendum to “Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs” [Heliyon 9(4) (April 2023) e15047] Open
View article: Early onset hereditary neuronopathies: an update on non-<i>5q</i>motor neuron diseases
Early onset hereditary neuronopathies: an update on non-<i>5q</i>motor neuron diseases Open
Hereditary motor neuropathies (HMN) were first defined as a group of neuromuscular disorders characterized by lower motor neuron dysfunction, slowly progressive length-dependent distal muscle weakness and atrophy, without sensory involveme…
View article: Evaluation of the combined effect of mobility and seasonality on the COVID-19 pandemic: a Lombardy-based study.
Evaluation of the combined effect of mobility and seasonality on the COVID-19 pandemic: a Lombardy-based study. Open
Restrictions to human mobility had a significant role in limiting SARS-CoV-2 spread. It has been suggested that seasonality might affect viral transmissibility. Our study retrospectively investigates the combined effect that seasonal envir…
View article: Neurofilament light chain as a biological marker for amyotrophic lateral sclerosis: a meta-analysis study
Neurofilament light chain as a biological marker for amyotrophic lateral sclerosis: a meta-analysis study Open
Aim: The aim of the present metanalysis is to evaluate blood and CSF Neurofilament light chain (NfL) concentrations in ALS patients, compared to healthy controls, ALS mimic disorders (ALSmd) and other neurological diseases (OND), an…
View article: Animal Models as a Tool to Design Therapeutical Strategies for CMT-like Hereditary Neuropathies
Animal Models as a Tool to Design Therapeutical Strategies for CMT-like Hereditary Neuropathies Open
Since ancient times, animal models have provided fundamental information in medical knowledge. This also applies for discoveries in the field of inherited peripheral neuropathies (IPNs), where they have been instrumental for our understand…
View article: Agrochemical Contamination of Honey and Bee Bread Collected in the Piedmont Region, Italy
Agrochemical Contamination of Honey and Bee Bread Collected in the Piedmont Region, Italy Open
This study shows the results of a local biomonitoring plan developed by a regional beekeeping association, Aspromiele, in several areas of Piedmont (Italy), in order to understand the status of contamination from pesticides present in the …
View article: Evaluation of the Combined Effect of Mobility and Seasonality on the COVID-19 Pandemic: A Lombardy-Based Study
Evaluation of the Combined Effect of Mobility and Seasonality on the COVID-19 Pandemic: A Lombardy-Based Study Open
Restrictions to human mobility had a significant role in limiting SARS-CoV-2 spread. It has been suggested that seasonality might affect viral transmissibility. Our study retrospectively investigates the combined effect that seasonal envir…
View article: Evaluation of the Combined Effect of Mobility and Seasonality on the COVID-19 Pandemic: A Lombardy-Based Study
Evaluation of the Combined Effect of Mobility and Seasonality on the COVID-19 Pandemic: A Lombardy-Based Study Open
View article: Abstracts of the 64th Annual Congress of the Italian Society for Clinical Neurophysiology
Abstracts of the 64th Annual Congress of the Italian Society for Clinical Neurophysiology Open
View article: Author response for "Hereditary spastic paraplegia is a novel phenotype for germline <i>de novo ATP1A1</i> mutation"
Author response for "Hereditary spastic paraplegia is a novel phenotype for germline <i>de novo ATP1A1</i> mutation" Open