Luca Brombal
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View article: Review of INFN activities on characterization and applications of hybrid pixel detectors based on Timepix4 ASIC
Review of INFN activities on characterization and applications of hybrid pixel detectors based on Timepix4 ASIC Open
The Medipix4 international collaboration represents a landmark initiative in the field of pixelated radiation imaging and detection. Building on the successes of its predecessors—the Medipix2 and Medipix3 collaborations—this effort has bee…
View article: A simulation tool for x-ray phase-contrast micro-CT featuring a small-pixel photon-counting detector
A simulation tool for x-ray phase-contrast micro-CT featuring a small-pixel photon-counting detector Open
X-ray micro-CT ( µ CT) is an important tool for high-resolution, non-destructive inspection of samples with numerous applications ranging from preclinical imaging to materials science. µ CT imaging capabilities can be expanded through the …
View article: A response matrix determined with a coincidence-based acquisition for correction of charge sharing spectral distortions in energy-resolved photon counting detectors
A response matrix determined with a coincidence-based acquisition for correction of charge sharing spectral distortions in energy-resolved photon counting detectors Open
A model-independent method is proposed to characterize and correct charge sharing spectral distortions in energy-resolved X-ray acquisitions with pixellated photon-counting detectors. The technique is based on the determination of a coinci…
View article: Comparison of three reconstruction algorithms for low‐dose phase‐contrast computed tomography of the breast with synchrotron radiation
Comparison of three reconstruction algorithms for low‐dose phase‐contrast computed tomography of the breast with synchrotron radiation Open
Background Phase‐contrast breast CT imaging holds promise for improved diagnostic accuracy, but an optimal reconstruction algorithm must balance objective image quality metrics with subjective radiologist preferences. Purpose This study sy…
View article: Spectral phase-contrast X-ray imaging with high-resolution detectors
Spectral phase-contrast X-ray imaging with high-resolution detectors Open
X-ray phase contrast imaging (XPCI) records phase shifts in X-rays as they pass through matter, enabling the distinction of features, such as soft tissues, that have low contrast in conventional absorption-based methods. Phase contrast bea…
View article: Timepix4 spatial response characterization with X-ray monochromatic synchrotron beam
Timepix4 spatial response characterization with X-ray monochromatic synchrotron beam Open
The Timepix4 is a readout ASIC developed by the Medipix4 collaboration, designed to work with various semiconductor sensors to form detection systems with 448×512 pixels with a pitch of 55 µm. Its ability to simultaneously measure the Time…
View article: Comparison of three reconstruction algorithms for low-dose phase-contrast computed tomography of the breast with synchrotron radiation
Comparison of three reconstruction algorithms for low-dose phase-contrast computed tomography of the breast with synchrotron radiation Open
Three different computed tomography (CT) reconstruction algorithms: Filtered Back Projection (FBP), Unified Tomographic Reconstruction (UTR) and customized Simultaneous Algebraic Reconstruction Technique (cSART), have been systematically c…
View article: WITHDRAWN: Evaluation of Spatial Performance in X-ray Imaging Detectors: CTF, MTF, LSF, and ESF Analysis
WITHDRAWN: Evaluation of Spatial Performance in X-ray Imaging Detectors: CTF, MTF, LSF, and ESF Analysis Open
The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be …
View article: Timepix4 characterization with monochromatic X-rays at the Elettra synchrotron facility
Timepix4 characterization with monochromatic X-rays at the Elettra synchrotron facility Open
View article: Validation of Timepix4 energy calibration procedures with synchrotron X-ray beams
Validation of Timepix4 energy calibration procedures with synchrotron X-ray beams Open
The Timepix4 is an application-specific integrated circuit developed by the Medipix4 collaboration. The chip is a 448x512 matrix that can be connected, via bump-bonding, to pixelated sensors of various materials and thicknesses, forming ap…
View article: Quantitative spectral micro-CT of a CA4+ loaded osteochondral sample with a tabletop system
Quantitative spectral micro-CT of a CA4+ loaded osteochondral sample with a tabletop system Open
Micro-computed tomography ( $$\upmu$$ CT) is the gold standard for nondestructive 3D imaging of biomedical samples in the centimeter scale, but it has limited effectiveness in revealing intricate soft tissue details due to the limited at…
View article: The EuAPS Betatron Radiation Source: Status Update and Photon Science Perspectives
The EuAPS Betatron Radiation Source: Status Update and Photon Science Perspectives Open
The EuPRAXIA EU project is at the forefront of advancing particle accelerator research and the development of photon sources through innovative plasma acceleration approaches. Within this framework, the EuAPS project aims to exploit laser …
View article: WITHDRAWN: Evaluation of Spatial Performance in X-ray Imaging Detectors: CTF, MTF, LSF, and ESF Analysis
WITHDRAWN: Evaluation of Spatial Performance in X-ray Imaging Detectors: CTF, MTF, LSF, and ESF Analysis Open
This study was conducted at the University of Trieste's Department of Physics, focusing on the comprehensive characterization of the spatial response of an X-ray imaging detector. The primary objective was to measure and analyze the Contra…
View article: A high sensitivity wide bandwidth spectral system for multiple K-edge imaging
A high sensitivity wide bandwidth spectral system for multiple K-edge imaging Open
Spectral K-edge subtraction (SKES) is an imaging technique that takes advantage of the sharp rise in the mass attenuation coefficient of specific elements within an object at their K-edge to produce separate and quantifiable distributions …
View article: Unveiling tumor invasiveness: enhancing cancer diagnosis with phase-contrast microtomography for 3D virtual histology
Unveiling tumor invasiveness: enhancing cancer diagnosis with phase-contrast microtomography for 3D virtual histology Open
Malignant diseases are characterized by a critical trait known as invasiveness, where tumor cells tend to spread from the primary tissue layer into surrounding healthy tissues and distant organs. Presently, histopathology offers essential …
View article: Spectral micro-CT for simultaneous gold and iodine detection, and multi-material identification
Spectral micro-CT for simultaneous gold and iodine detection, and multi-material identification Open
Multiple energy bin spectral micro-CT (S μ CT) is an advanced imaging technique that allows multi-material decomposition according to their specific absorption patterns at a sub-100 μm scale. Typically, iodine is the preferred CT contrast …
View article: Edge-illumination spectral phase-contrast tomography
Edge-illumination spectral phase-contrast tomography Open
Following the rapid, but independent, diffusion of x-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination tech…
View article: Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis
Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis Open
Detecting breast tissue alterations is essential for cancer diagnosis. However, inherent bidimensionality limits histological procedures’ effectiveness in identifying these changes. Our study applies a 3D virtual histology method based on …
View article: On the equivalence of the X-ray scattering retrieval with beam tracking and analyser-based imaging using a synchrotron source
On the equivalence of the X-ray scattering retrieval with beam tracking and analyser-based imaging using a synchrotron source Open
X-ray phase contrast imaging (XPCI) methods give access to contrast mechanisms that are based on the refractive properties of matter on top of the absorption coefficient in conventional x-ray imaging. Ultra small angle x-ray scattering (US…
View article: Characterization of breast tissues in density and effective atomic number basis via spectral X-ray computed tomography
Characterization of breast tissues in density and effective atomic number basis via spectral X-ray computed tomography Open
Objective. Differentiation of breast tissues is challenging in X-ray imaging because tissues might share similar or even the same linear attenuation coefficients μ . Spectral computed tomography (CT) allows for more quantitative characteri…
View article: PEPI Lab: a flexible compact multi-modal setup for X-ray phase-contrast and spectral imaging
PEPI Lab: a flexible compact multi-modal setup for X-ray phase-contrast and spectral imaging Open
This paper presents a new flexible compact multi-modal imaging setup referred to as PEPI (Photon-counting Edge-illumination Phase-contrast imaging) Lab, which is based on the edge-illumination (EI) technique and a chromatic detector. The s…
View article: Characterization of breast tissues in density and effective atomic number basis via spectral X-ray computed tomography
Characterization of breast tissues in density and effective atomic number basis via spectral X-ray computed tomography Open
Differentiation of breast tissues is challenging in X-ray imaging because tissues might share similar or even the same linear attenuation coefficients $μ$. Spectral computed tomography (CT) allows for more quantitative characterization in …
View article: Unified Modulation Pattern Analysis (UMPA) algorithm for 1D sensitive X-ray phase contrast imaging techniques
Unified Modulation Pattern Analysis (UMPA) algorithm for 1D sensitive X-ray phase contrast imaging techniques Open
X-ray phase contrast imaging (XPCI) techniques are sensitive to refraction (differential-phase) and small-angle X-ray scattering (dark-field) signals, not measurable with conventional absorption imaging techniques. Among XPCI techniques, e…
View article: Propagation-based phase-contrast breast computed tomography: a visual grading assessment of the performance of photon-counting and flat-panel X-ray detectors
Propagation-based phase-contrast breast computed tomography: a visual grading assessment of the performance of photon-counting and flat-panel X-ray detectors Open
Rationale and objectives Breast cancer represents the leading cause of death from cancer in women worldwide. Early detection of breast tumours improves the prognosis and survival rate. Propagation-based phase-contrast computed tomography (…
View article: Development and validation of a simulation tool for K-edge Subtraction imaging with polychromatic spectra and X-ray photon counting detectors
Development and validation of a simulation tool for K-edge Subtraction imaging with polychromatic spectra and X-ray photon counting detectors Open
View article: Multi-material spectral photon-counting micro-CT with minimum residual decomposition and self-supervised deep denoising
Multi-material spectral photon-counting micro-CT with minimum residual decomposition and self-supervised deep denoising Open
Spectral micro-CT imaging with direct-detection energy discriminating photon counting detectors having small pixel size (< 100×100 µm 2 ) is mainly hampered by: i) the limited energy resolution of the imaging device due to charge sharing e…
View article: Optimization of a customized simultaneous algebraic reconstruction technique algorithm for phase-contrast breast computed tomography
Optimization of a customized simultaneous algebraic reconstruction technique algorithm for phase-contrast breast computed tomography Open
Objective. To introduce the optimization of a customized GPU-based simultaneous algebraic reconstruction technique (cSART) in the field of phase-contrast breast computed tomography (bCT). The presented algorithm features a 3D bilateral reg…
View article: A Geant4 tool for edge-illumination X-ray phase-contrast imaging
A Geant4 tool for edge-illumination X-ray phase-contrast imaging Open
The PEPI project is developing a new experimental facility integrating a chromatic photon-counting detector within an edge-illumination (EI) phase-contrast setup. In this context, a novel Geant4-based simulation tool has been introduced wi…
View article: A method for the quantitative discrimination of breast tissue chemical composition based on the spectral decomposition of x-ray tomographic breast images
A method for the quantitative discrimination of breast tissue chemical composition based on the spectral decomposition of x-ray tomographic breast images Open
View article: Motion artifacts assessment and correction using optical tracking in synchrotron radiation breast CT
Motion artifacts assessment and correction using optical tracking in synchrotron radiation breast CT Open
Purpose The SYRMA‐3D collaboration is setting up a breast computed tomography (bCT) clinical program at the Elettra synchrotron radiation facility in Trieste, Italy. Unlike the few dedicated scanners available at hospitals, synchrotron rad…