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View article: Weight Changes during Early Breast Cancer Treatment and Their Association with Survival: An Exploratory Functional Data Analysis of GIM-2 Trial
Weight Changes during Early Breast Cancer Treatment and Their Association with Survival: An Exploratory Functional Data Analysis of GIM-2 Trial Open
Introduction Limited evidence is available on the impact of early breast cancer (EBC) treatments on body weight. Notably, robust data quantifying the magnitude and timing of weight changes during treatment are lacking, and existing finding…
View article: Validation of the Italian Version of the Rapid Geriatric Assessment in Community-Dwelling Older Adults
Validation of the Italian Version of the Rapid Geriatric Assessment in Community-Dwelling Older Adults Open
Background/Objectives: The Rapid Geriatric Assessment (RGA) is a tool designed to screen for frailty, sarcopenia, anorexia related to aging, and cognitive impairment. This study aimed to translate and validate the RGA for use among Italian…
View article: Hearing loss predictive model in fibrodysplasia ossificans progressiva from a national referral center: developing an hearing loss predictive model
Hearing loss predictive model in fibrodysplasia ossificans progressiva from a national referral center: developing an hearing loss predictive model Open
Fibrodysplasia ossificans progressiva (FOP) is the most dramatic form of progressive heterotopic ossification of soft tissues. Hearing impairment in FOP patient is a common feature, reported by about 50% of affected patients. However, wide…
View article: Uncovering a Bias in Estimated Treatment Effects on PIRA in Multiple Sclerosis Clinical Trials
Uncovering a Bias in Estimated Treatment Effects on PIRA in Multiple Sclerosis Clinical Trials Open
View article: Emergency Department admissions for Acute Respiratory Infections: a retrospective analysis
Emergency Department admissions for Acute Respiratory Infections: a retrospective analysis Open
Background Acute Respiratory Infections (ARIs) have a relevant impact on public health in terms of prevalence and costs associated with the diseases. The COVID-19 pandemic highlighted the need to adopt accurate surveillance systems to resp…
View article: Synthetic data in Multiple Sclerosis: replicating the results of a clinical trial with artificially generated data.
Synthetic data in Multiple Sclerosis: replicating the results of a clinical trial with artificially generated data. Open
Background Collecting high quality, patient level data demands significant efforts and resources. A potential solution, well-suited for exploratory hypothesis testing, gathering evidence, and assessing the heterogeneity and generalizabilit…
View article: Composite Prediction Score to Interpret Bone Focal Uptake in Hormone-Sensitive Prostate Cancer Patients Imaged with [<sup>18</sup>F]PSMA-1007 PET/CT
Composite Prediction Score to Interpret Bone Focal Uptake in Hormone-Sensitive Prostate Cancer Patients Imaged with [<sup>18</sup>F]PSMA-1007 PET/CT Open
Unspecific bone uptake (UBU) related to [18F]PSMA-1007 PET/CT imaging represents a clinical challenge. We aimed to assess whether a combination of clinical, biochemical, and imaging parameters could predict skeletal metastases i…
View article: Investigating Functional Data Analysis for Wearable Physiological Sensor Data in Stress Evaluation
Investigating Functional Data Analysis for Wearable Physiological Sensor Data in Stress Evaluation Open
Measuring stress level objectively is crucial for personalized health monitoring. While traditional methods require a clinical setting, wearables provide a valuable alternative. In this paper, we approach stress assessment as a regression …
View article: Characterization of HER2‐low breast cancer in young women with germline <i>BRCA1/2</i> pathogenetic variants: Results of a large international retrospective cohort study
Characterization of HER2‐low breast cancer in young women with germline <i>BRCA1/2</i> pathogenetic variants: Results of a large international retrospective cohort study Open
Background Breast cancer (BC) in women aged ≤40 years carrying germline pathogenetic variants (PVs) in BRCA1/2 genes is infrequent but often associated with aggressive features. Human epidermal growth factor receptor 2 (HER2)‐low‐expressin…
View article: 154P Validation of PREDICT tool version 2.2 in early-stage breast cancer (BC) patients enrolled in adjuvant trials by the Gruppo Italiano Mammella (GIM) and Mammella Intergruppo (MIG)
154P Validation of PREDICT tool version 2.2 in early-stage breast cancer (BC) patients enrolled in adjuvant trials by the Gruppo Italiano Mammella (GIM) and Mammella Intergruppo (MIG) Open
PREDICT, an online prognostic tool developed from population registries, estimates the potential benefit of different treatments (i.e., surgery alone, chemotherapy, trastuzumab, endocrine therapy, and/or bisphosphonates) for early-stage BC…
View article: Intermediate clinical endpoints in early-stage breast cancer: an analysis of individual patient data from the Gruppo Italiano Mammella and Mammella Intergruppo trials
Intermediate clinical endpoints in early-stage breast cancer: an analysis of individual patient data from the Gruppo Italiano Mammella and Mammella Intergruppo trials Open
View article: Creating an automated tool for a consistent and repeatable evaluation of disability progression in clinical studies for Multiple Sclerosis
Creating an automated tool for a consistent and repeatable evaluation of disability progression in clinical studies for Multiple Sclerosis Open
Background The lack of standardized disability progression evaluation in multiple sclerosis (MS) hinders reproducibility of clinical study results, due to heterogeneous and poorly reported criteria. Objectives To demonstrate the impact of …
View article: Biometry extraction and probabilistic anatomical atlas of the anterior Visual Pathway using dedicated high-resolution 3-D MRI
Biometry extraction and probabilistic anatomical atlas of the anterior Visual Pathway using dedicated high-resolution 3-D MRI Open
View article: Ruling Out Left Main Stem Stenosis by Clinical and Stress ECG Variables: The MASTER Case-Control Multicenter Study
Ruling Out Left Main Stem Stenosis by Clinical and Stress ECG Variables: The MASTER Case-Control Multicenter Study Open
View article: Response to Ustekinumab Therapy Is Associated with an Improvement of Nutritional Status in Patients with Crohn’s Disease
Response to Ustekinumab Therapy Is Associated with an Improvement of Nutritional Status in Patients with Crohn’s Disease Open
The presence of sarcopenia has been associated with the worst outcome of Crohn’s disease (CD). At present, no studies have evaluated the impact of ustekinumab (UST) in terms of its effects on body composition. The aim of this prospective s…
View article: Trans-synaptic degeneration in the optic pathway: Exploring the role of lateral geniculate nucleus in early stages of relapsing-remitting multiple sclerosis
Trans-synaptic degeneration in the optic pathway: Exploring the role of lateral geniculate nucleus in early stages of relapsing-remitting multiple sclerosis Open
View article: Acute respiratory virus emergency department admissions in a tertiary care hospital in Central Italy and the relative impact on bed occupancy, January 2017-May 2022
Acute respiratory virus emergency department admissions in a tertiary care hospital in Central Italy and the relative impact on bed occupancy, January 2017-May 2022 Open
Acute Respiratory Infections (ARIs) have a relevant impact on public health in terms of prevalence and costs associated with the diseases. This concern highlighted the need to adopt accurate surveillance systems to respond to new emergenci…
View article: Oncoplastic level II volume displacement surgery for breast cancer: oncological and aesthetic outcomes
Oncoplastic level II volume displacement surgery for breast cancer: oncological and aesthetic outcomes Open
View article: Linguistic profile automated characterisation in pluripotential clinical high-risk mental state (CHARMS) conditions: methodology of a multicentre observational study
Linguistic profile automated characterisation in pluripotential clinical high-risk mental state (CHARMS) conditions: methodology of a multicentre observational study Open
Introduction Language is usually considered the social vehicle of thought in intersubjective communications. However, the relationship between language and high-order cognition seems to evade this canonical and unidirectional description (…
View article: Clinical and MRI measures to identify non-acute MOG-antibody disease in adults
Clinical and MRI measures to identify non-acute MOG-antibody disease in adults Open
MRI and clinical features of myelin oligodendrocyte glycoprotein (MOG)-antibody disease may overlap with those of other inflammatory demyelinating conditions posing diagnostic challenges, especially in non-acute phases and when serologic t…
View article: The impact of PM2.5, PM10 and NO2 on Covid-19 severity in a sample of patients with multiple sclerosis: A case-control study
The impact of PM2.5, PM10 and NO2 on Covid-19 severity in a sample of patients with multiple sclerosis: A case-control study Open
View article: Adalimumab Originator vs. Biosimilar in Hidradenitis Suppurativa: A Multicentric Retrospective Study
Adalimumab Originator vs. Biosimilar in Hidradenitis Suppurativa: A Multicentric Retrospective Study Open
This study aimed to compare adalimumab originator vs. biosimilar in HS patients, and to evaluate the effect of a switch to a biosimilar, or a switch back to the originator, in terms of treatment ineffectiveness. Patients with a diagnosis o…
View article: Understanding the value of non-specific abnormal capillary dilations in presence of Raynaud’s phenomenon: a detailed capillaroscopic analysis
Understanding the value of non-specific abnormal capillary dilations in presence of Raynaud’s phenomenon: a detailed capillaroscopic analysis Open
Background Nailfold videocapillaroscopy (NVC) non-specific abnormalities may be present in subjects with isolated Raynaud’s phenomenon (RP) before the potential transition to systemic sclerosis (SSc) specific microvascular alterations (‘sc…
View article: Microvascular capillaroscopic abnormalities and occurrence of antinuclear autoantibodies in patients with sarcoidosis
Microvascular capillaroscopic abnormalities and occurrence of antinuclear autoantibodies in patients with sarcoidosis Open
We described nailfold videocapillaroscopy (NVC) findings and estimated the prevalence of serum anti-nuclear (ANA) and extractable nuclear antigen autoantibodies (ENA) in a cohort of sarcoidosis patients, comparing them with adequate health…
View article: Safety and Efficacy of Eucaloric Very Low-Carb Diet (EVLCD) in Type 1 Diabetes: A One-Year Real-Life Retrospective Experience
Safety and Efficacy of Eucaloric Very Low-Carb Diet (EVLCD) in Type 1 Diabetes: A One-Year Real-Life Retrospective Experience Open
A eucaloric very low carbohydrate diet (EVLCD) is a diet with a daily caloric intake equal to the total daily energy expenditure (TDEE) with a carbohydrate content of <50 g/day. The literature on very low carbohydrate diets (VLCD) in type …
View article: RONC-10. Radiation-induced hypothyroidism in pediatric brain tumour survivors: radiation dose-volume predictors of its onset
RONC-10. Radiation-induced hypothyroidism in pediatric brain tumour survivors: radiation dose-volume predictors of its onset Open
BACKGROUND: Central hypothyroidism is a well-known late effect of radiotherapy in children treated for brain tumours. AIM: To determine the risk of central hypothyroidism (CH) and the radiation dose-volume predictors of its onset. METHODS:…
View article: Nonlesional Sources of Contrast Enhancement on Postgadolinium “Black-Blood” 3D T1-SPACE Images in Patients with Multiple Sclerosis
Nonlesional Sources of Contrast Enhancement on Postgadolinium “Black-Blood” 3D T1-SPACE Images in Patients with Multiple Sclerosis Open
Small intraparenchymal veins may confound the diagnosis of enhancing lesions on postgadolinium black-blood SPACE images.
View article: A multiparametric score for assessing the individual risk of severe Covid-19 among patients with Multiple Sclerosis
A multiparametric score for assessing the individual risk of severe Covid-19 among patients with Multiple Sclerosis Open
View article: Implementation of a distance learning hand eczema prevention program for healthcare workers during the COVID‐19 pandemic
Implementation of a distance learning hand eczema prevention program for healthcare workers during the COVID‐19 pandemic Open
Occupational hand eczema (HE) is a major risk for healthcare workers. It is attributed to hand hygiene practices, in particular to frequent hand washing and use of occlusive gloves. Programs of skin care education are beneficial for its pr…
View article: Breakthrough SARS-CoV-2 infections after COVID-19 mRNA vaccination in MS patients on disease modifying therapies during the Delta and the Omicron waves in Italy
Breakthrough SARS-CoV-2 infections after COVID-19 mRNA vaccination in MS patients on disease modifying therapies during the Delta and the Omicron waves in Italy Open