Luca Del Core
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View article: Inferring ion channel block from rabbit Purkinje fiber action potential recordings
Inferring ion channel block from rabbit Purkinje fiber action potential recordings Open
View article: Parameter inference for stochastic reaction models of ion channel gating from whole-cell voltage-clamp data
Parameter inference for stochastic reaction models of ion channel gating from whole-cell voltage-clamp data Open
Mathematical models of ion channel gating describe the changes in ion channel configurations due to the electrical activity of the cell membrane. Experimental findings suggest that ion channels behave randomly, and therefore stochastic mod…
View article: Scalable inference of cell differentiation networks in gene therapy clonal tracking studies of haematopoiesis
Scalable inference of cell differentiation networks in gene therapy clonal tracking studies of haematopoiesis Open
Motivation Investigating cell differentiation under a genetic disorder offers the potential for improving current gene therapy strategies. Clonal tracking provides a basis for mathematical modelling of population stem cell dynamics that su…
View article: A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies
A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies Open
Background Mathematical models of haematopoiesis can provide insights on abnormal cell expansions (clonal dominance), and in turn can guide safety monitoring in gene therapy clinical applications. Clonal tracking is a recent high-throughpu…
View article: Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy Open
View article: The stochastic route of haematopoiesis
The stochastic route of haematopoiesis Open
Gene therapy is a novel clinical treatment for curing rare genetic diseases or moderating their effects. The success of this therapy depends on the ability of the modified stem cells to replace the faulty genes with functioning copies, cal…
View article: Stochastic modelling of cell differentiation networks from partially-observed clonal tracking data
Stochastic modelling of cell differentiation networks from partially-observed clonal tracking data Open
Motivation Clarifying how hematopoietic stem cells differentiate into mature cell types is important for understanding how they attain specific functions and offers the potential for therapeutic manipulation. Over the past decades, clonal …
View article: Stochastic inference of clonal dominance in gene therapy studies
Stochastic inference of clonal dominance in gene therapy studies Open
Clonal dominance is a wake-up-call for adverse events in gene therapy applications. This phenomenon has mainly been observed as a consequence of a malignancy progression, and, in some rare cases, also during normal haematopoiesis. We propo…
View article: Normalization of clonal diversity in gene therapy studies using shape constrained splines
Normalization of clonal diversity in gene therapy studies using shape constrained splines Open