Luca Denaro
YOU?
Author Swipe
View article: Comparative Outcomes of Direct Versus Connector-Assisted Peripheral Nerve Repair
Comparative Outcomes of Direct Versus Connector-Assisted Peripheral Nerve Repair Open
Background: Peripheral nerve injuries affect a significant proportion of patients with upper extremity trauma, with transections frequently requiring surgical intervention. While direct repair (DR) remains the historical standard, connecto…
View article: PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics
PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics Open
Background Bulk RNA sequencing (RNA-seq) has substantially advanced the understanding of pituitary neuroendocrine tumors (PitNETs). However, its limited ability to resolve cellular heterogeneity – particularly in samples containing residua…
View article: Real-life data on pasireotide in monotherapy or combined in active Cushing’s disease
Real-life data on pasireotide in monotherapy or combined in active Cushing’s disease Open
Introduction In the last few years, the use of medical treatment in Cushing’s disease (CD) has increased thanks to the availability of new molecules. Nevertheless, real-life data on combination treatments are still lacking. Methods This is…
View article: Intraoperative Ultrasound in the Management of Rare Lesions Involving the Intradural Extramedullary Spinal Compartment: A Quick, but Effective Helping Hand to Define the Optimal Surgical Strategy
Intraoperative Ultrasound in the Management of Rare Lesions Involving the Intradural Extramedullary Spinal Compartment: A Quick, but Effective Helping Hand to Define the Optimal Surgical Strategy Open
Intraoperative ultrasound (IOUS) is an increasingly adopted adjunctive intraoperative visualization method in spinal tumor surgery, offering real-time imaging that improves lesion localization, exposure planning, and resection control. Thi…
View article: Targeted and Systemic therapies for recurrent adult ependymomas: real- world outcomes from a single institution and concise literature review
Targeted and Systemic therapies for recurrent adult ependymomas: real- world outcomes from a single institution and concise literature review Open
Purpose: Recurrent adult ependymomas lack standard systemic therapies and evidence on chemotherapy and targeted agents is limited. This study aimed to retrospectively evaluated outcomes of systemic therapies, including targeted combination…
View article: Beyond Molecular Characterization: The Impact of Age-Adjusted Charlson Comorbidity Index in Glioblastoma Patients Treated with Radio or Radio-Chemotherapy
Beyond Molecular Characterization: The Impact of Age-Adjusted Charlson Comorbidity Index in Glioblastoma Patients Treated with Radio or Radio-Chemotherapy Open
Background: Glioblastoma (GBM) prognosis has been reported to be influenced by age and comorbidity in several investigations. Identifying factors that contribute to poor survival is crucial to optimizing and personalizing therapeutic strat…
View article: Real-world management and long-term outcomes in adolescent, young adult, and adult medulloblastoma: Experience from a monocentric series with multimodal and targeted approaches
Real-world management and long-term outcomes in adolescent, young adult, and adult medulloblastoma: Experience from a monocentric series with multimodal and targeted approaches Open
Abstract Background Medulloblastoma (MB) is an exceedingly rare malignancy in adolescents and young adults (AYA) and adults. This study aims to describe clinical characteristics, treatments, including the use of targeted therapy, outcomes,…
View article: P03.07.B STRUCTURAL CONNECTIVITY-BASED SPREADING PATTERNS OF MULTIFOCAL AND MULTICENTRIC GLIOMAS
P03.07.B STRUCTURAL CONNECTIVITY-BASED SPREADING PATTERNS OF MULTIFOCAL AND MULTICENTRIC GLIOMAS Open
BACKGROUND Gliomas are hypothesized to spread along white matter tracts (WMT); coherently, it was discovered that the density of WMT overlapped by glioblastomas (“tract density index”/”TDI”) negatively correlates with patient prognosis. We…
View article: Clinical presentation, predictive factors and management of patients with Nelson syndrome: a retrospective study
Clinical presentation, predictive factors and management of patients with Nelson syndrome: a retrospective study Open
Background Nelson syndrome (NS), or corticotroph tumor progression after bilateral adrenalectomy (CTP-BADX/NS), is a serious complication in patients with Cushing disease (CD) following BADX. Surgical tumor removal is the recommended treat…
View article: Advanced MRI, Radiomics and Radiogenomics in Unravelling Incidental Glioma Grading and Genetic Status: Where Are We?
Advanced MRI, Radiomics and Radiogenomics in Unravelling Incidental Glioma Grading and Genetic Status: Where Are We? Open
The 2021 WHO classification of brain tumours revolutionised the oncological field by emphasising the role of molecular, genetic and pathogenetic advances in classifying brain tumours. In this context, incidental gliomas have been increasin…
View article: Outcomes of the Transsphenoidal Approach for ACTH-Secreting Pituitary Tumours and the Role of Postoperative ACTH in Predicting the Late Recurrence of Cushing’s Disease: A Retrospective Analysis of 50 Cases
Outcomes of the Transsphenoidal Approach for ACTH-Secreting Pituitary Tumours and the Role of Postoperative ACTH in Predicting the Late Recurrence of Cushing’s Disease: A Retrospective Analysis of 50 Cases Open
Background/Objectives: The endoscopic transsphenoidal approach constitutes an excellent technique for adrenocorticotropin hormone (ACTH)-producing pituitary tumours. It is associated with subnormal postoperative serum cortisol levels, whic…
View article: Glioblastoma in NF1: A Unique Entity—A Literature Review Focusing on Surgical Implication and Our Experience
Glioblastoma in NF1: A Unique Entity—A Literature Review Focusing on Surgical Implication and Our Experience Open
Glioblastoma in patients affected by NF1 germline mutation (NF1-associated GBM) represents a unique heterogeneous clinical and pathological entity. We have reviewed the few cases reported in the literature and they seem to have a better re…
View article: A Data-Driven Approach for Rathke’s Cleft Cysts Management
A Data-Driven Approach for Rathke’s Cleft Cysts Management Open
Background: Rathke’s cleft cysts (RCCs) are non-neoplastic and rare sellar lesions derived from remnants of Rathke’s pouch. While asymptomatic RCCs often require only conservative management, symptomatic cases may necessitate surgical inte…
View article: Bevacizumab in recurrent glioblastoma: does dose matter? Our monocentric and comparative experience
Bevacizumab in recurrent glioblastoma: does dose matter? Our monocentric and comparative experience Open
View article: Prospective Evaluation of Transsphenoidal Pituitary Surgery in Patients with Cushing’s Disease: Delayed Remission and the Role of Postsurgical Cortisol as a Predictive Factor
Prospective Evaluation of Transsphenoidal Pituitary Surgery in Patients with Cushing’s Disease: Delayed Remission and the Role of Postsurgical Cortisol as a Predictive Factor Open
Background. Transsphenoidal surgery is the treatment of choice for Cushing’s disease. Successful surgery is associated with subnormal postoperative serum cortisol concentrations and cortisoluria levels, which may guide decisions regarding …
View article: Electrochemotherapy in Spine Metastases: A Case Series Focused on Technical Aspects, Surgical Strategies and Results
Electrochemotherapy in Spine Metastases: A Case Series Focused on Technical Aspects, Surgical Strategies and Results Open
Metastases are complications of primary tumors due to prolonged cancer survival and have become an important issue for oncological patients and the most frequent cause of death and disability. Bone metastases occur at a later stage of canc…
View article: Indirect functional connectivity does not predict overall survival in glioblastoma
Indirect functional connectivity does not predict overall survival in glioblastoma Open
View article: HER2 expression and genOmic characterization of rESected brain metastases from colorectal cancer: the HEROES study
HER2 expression and genOmic characterization of rESected brain metastases from colorectal cancer: the HEROES study Open
View article: Relationship between glioblastoma location and O6-methylguanine-DNA methyltransferase promoter methylation percentage
Relationship between glioblastoma location and O6-methylguanine-DNA methyltransferase promoter methylation percentage Open
A large literature assessed the relationships between the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status and glioblastoma location with inconsistent results. Studies assessing this association using the percentag…
View article: Role of Vagus Nerve Stimulation in Refractory and Super Refractory Status Epilepticus: A Pediatric Case Series
Role of Vagus Nerve Stimulation in Refractory and Super Refractory Status Epilepticus: A Pediatric Case Series Open
Background: Status epilepticus is a life-threatening condition that is defined as refractory (RSE) when the seizure activity continues despite treatment with benzodiazepine and a second appropriate treatment. Super refractory status epilep…
View article: Thalamopeduncular Tumors in Pediatric Age: Advanced Preoperative Imaging to Define Safe Surgical Planning: A Multicentric Experience
Thalamopeduncular Tumors in Pediatric Age: Advanced Preoperative Imaging to Define Safe Surgical Planning: A Multicentric Experience Open
Background: Thalamopeduncular tumors are challenging lesions arising at the junction between the thalamus and the cerebral peduncle. They represent 1–5% of pediatric brain tumors, are mainly pilocytic astrocytoma and occur within the first…
View article: Complications and mortality of Cushing’s disease: report on data collected over a 20-year period at a referral centre
Complications and mortality of Cushing’s disease: report on data collected over a 20-year period at a referral centre Open
View article: Patterns of gray and white matter functional networks involvement in glioblastoma patients: indirect mapping from clinical MRI scans
Patterns of gray and white matter functional networks involvement in glioblastoma patients: indirect mapping from clinical MRI scans Open
Background Resting-state functional-MRI studies identified several cortical gray matter functional networks (GMNs) and white matter functional networks (WMNs) with precise anatomical localization. Here, we aimed at describing the relations…
View article: Association between thyroid function and regorafenib efficacy in patients with relapsed wild-type IDH glioblastoma: a large multicenter study
Association between thyroid function and regorafenib efficacy in patients with relapsed wild-type IDH glioblastoma: a large multicenter study Open
View article: The Methylation Analysis of the Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Locus in GH-Secreting Pituitary Adenomas
The Methylation Analysis of the Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Locus in GH-Secreting Pituitary Adenomas Open
The glucose-dependent insulinotropic polypeptide receptor (GIPR) is aberrantly expressed in about one-third of GH-secreting pituitary adenomas (GH-PAs) and has been associated with a paradoxical increase of GH after a glucose load. The rea…
View article: Selective Stimulus Intensity during Hotspot Search Ensures Faster and More Accurate Preoperative Motor Mapping with nTMS
Selective Stimulus Intensity during Hotspot Search Ensures Faster and More Accurate Preoperative Motor Mapping with nTMS Open
Introduction: Navigated transcranial magnetic stimulation (nTMS) has emerged as one of the most innovative techniques in neurosurgical practice. However, nTMS motor mapping involves rigorous steps, and the importance of an accurate executi…
View article: Metronomic Temozolomide in Heavily Pretreated Patients With Recurrent Isocitrate Dehydrogenase Wild-type Glioblastoma: A Large Real-Life Mono-Institutional Study
Metronomic Temozolomide in Heavily Pretreated Patients With Recurrent Isocitrate Dehydrogenase Wild-type Glioblastoma: A Large Real-Life Mono-Institutional Study Open
Rechallenge with metronomic TMZ is a well-tolerated option for recurrent GBM, even in pretreated patients. Patients with methylated MGMT disease and good ECOG-PS seem to benefit the most from this treatment.
View article: Navigated Transcranial Magnetic Stimulation Motor Mapping and Diffusion Tensor Imaging Tractography for Diencephalic Tumor in Pediatric Patients
Navigated Transcranial Magnetic Stimulation Motor Mapping and Diffusion Tensor Imaging Tractography for Diencephalic Tumor in Pediatric Patients Open
Background. In deep-seated brain tumors, adequate preoperative planning is mandatory to assess the best surgical corridor to obtain maximal safe resection. Functional diffusor tensor imaging (DTI) tractography based on navigated transcrani…
View article: Trends in Hospitalization and Economic Impact of Percutaneous Kyphoplasty in Italy
Trends in Hospitalization and Economic Impact of Percutaneous Kyphoplasty in Italy Open
Vertebral Fractures (VFs) caused by osteoporosis are the most typical reason for performing Percutaneous Kyphoplasty (PK). Globally, VF prevalence is not well described in the literature. In Europe, only Sweden has an accurate record of th…
View article: Starting point for benchmarking outcomes and reporting of pituitary adenoma surgery within the European Reference Network on Rare Endocrine Conditions (Endo-ERN): results from a meta-analysis and survey study
Starting point for benchmarking outcomes and reporting of pituitary adenoma surgery within the European Reference Network on Rare Endocrine Conditions (Endo-ERN): results from a meta-analysis and survey study Open
Objective The European Reference Network on Rare Endocrine Conditions (Endo-ERN) aims to organize high-quality healthcare throughout Europe, including care for pituitary adenoma patients. As surgery is the mainstay of treatment, we aimed t…