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View article: Supplementary Table S4 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Table S4 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Table S4
View article: Supplementary Figure legends from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Figure legends from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary figure legends
View article: Supplementary Figures from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Figures from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Figures 1-4, Tables S1 and S5
View article: Supplementary Table S3 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Table S3 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Table S3
View article: Figure S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 2. Transcriptomic characterization of healthy liver and Kupffer cells
View article: Data from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Data from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Early synchronous colorectal liver metastasis (CRLM) represents a clinical condition characterized by the simultaneous presence of primary colorectal cancer and metastatic liver lesions. In this study, we characterized the tissue-specific …
View article: Figure S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 3. Transcriptomic characterization of pathologic and healthy monocytes in the peripheral blood
View article: Figure S5 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S5 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 5. Differences between inflammatory and immunoregulatory TAMs in colon and liver
View article: Table S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 1. List of significant genes (FDR-adjusted p-value < 0.05, and |Log2-FoldChange| > 0.25, detected in not less than 10% of cells) identified from in each tissue-specific cluster within pathologic colon, liver, and periph…
View article: Table S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 4. List of genes used to compute the gene module scores related to the cell cycle proliferation score (n genes = 57). Table related to Fig. 5D.
View article: Table S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 3. List of significant genes (FDR-adjusted p-value < 0.05, and |Log2-FoldChange| > 0.25, detected in not less than 10% of cells) identified from the comparison Liver vs Colon within the inflammatory or immunoregulatory …
View article: Figure S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 1. scRNA-sequencing analysis of early phases synchronous CRLM patients
View article: Figure S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 4. Pseudotime trajectory analysis shows macrophage blood derivation
View article: Table S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table S2: List of genes used to compute the gene module scores related to the antigen-presentation (n genes = 24), lipid-associated (n genes = 32), angiogenic (n genes = 31<…
View article: Loss of hormone receptor expression in breast tissue following pre‐surgical therapy with an <scp>SERD</scp>
Loss of hormone receptor expression in breast tissue following pre‐surgical therapy with an <span>SERD</span> Open
View article: Practical consequences of the European union-AI act for anatomic pathology laboratories a European society of pathology and European society of digital and integrative pathology commissioned expert opinion paper
Practical consequences of the European union-AI act for anatomic pathology laboratories a European society of pathology and European society of digital and integrative pathology commissioned expert opinion paper Open
The European Union Artificial Intelligence Act (AI Act) introduces a landmark regulatory framework governing the development, deployment, and post-marketing requirements and maintenance of AI systems, with growing relevance for the field o…
View article: Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome
Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome Open
Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive biliary tract cancer with a poor prognosis and a complex tumour microenvironment (TME) that remains poorly understood. Objective This study aimed to investigate the p…
View article: Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Early synchronous colorectal liver metastasis (CRLM) represents a clinical condition characterized by the simultaneous presence of primary colorectal cancer and metastatic liver lesions. In this study, we characterized the tissue-specific …
View article: Role of Gut‐Derived Endotoxins in Porto‐Sinusoidal Vascular Disorder: Comparison Between patients with and without portal hypertension
Role of Gut‐Derived Endotoxins in Porto‐Sinusoidal Vascular Disorder: Comparison Between patients with and without portal hypertension Open
Background Etiopathogenesis of porto‐sinusoidal vascular disorder (PSVD) is poorly known. The present study aimed to investigate alterations in gut barrier, bacterial translocation, and pro‐aggregating/pro‐coagulant state and their relatio…
View article: Reply: Diagnostic accuracy of ChatGPT-4 and liver fibrosis in MASH
Reply: Diagnostic accuracy of ChatGPT-4 and liver fibrosis in MASH Open
View article: MRI-based radiomics predicts the pathologic response of colorectal liver metastases to systemic therapy: A multicenter study
MRI-based radiomics predicts the pathologic response of colorectal liver metastases to systemic therapy: A multicenter study Open
The addition of radiomic features extracted from the PVP and HBP of post-chemotherapy Gd-EOB-DTPA-enhanced MRI enhanced standard radiologic and clinical assessment of CRLM response to chemotherapy, providing a reliable non-invasive assessm…
View article: Digital Histopathology and <scp>AI</scp>: A New Era of Liver Fibrosis Quantification
Digital Histopathology and <span>AI</span>: A New Era of Liver Fibrosis Quantification Open
View article: Breath profiles in paediatric allergic asthma by proton transfer reaction mass spectrometry
Breath profiles in paediatric allergic asthma by proton transfer reaction mass spectrometry Open
Introduction Enhancing paediatric asthma diagnosis is crucial. Molecular analysis of exhaled breath is a rapidly evolving field aimed at harnessing established and innovative technologies for clinical applications. This study evaluates the…
View article: Assessing the diagnostic accuracy of ChatGPT-4 in the histopathological evaluation of liver fibrosis in MASH
Assessing the diagnostic accuracy of ChatGPT-4 in the histopathological evaluation of liver fibrosis in MASH Open
Background: Large language models like ChatGPT have demonstrated potential in medical image interpretation, but their efficacy in liver histopathological analysis remains largely unexplored. This study aims to assess ChatGPT-4-vision's dia…
View article: Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity
Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity Open
View article: The Rare Entity of Basaloid Thymic Carcinoma: A Multicentric Retrospective Analysis from the Italian Collaborative Group for ThYmic MalignanciEs (TYME)
The Rare Entity of Basaloid Thymic Carcinoma: A Multicentric Retrospective Analysis from the Italian Collaborative Group for ThYmic MalignanciEs (TYME) Open
Background: thymic basaloid carcinoma (BTC) is an extremely rare tumor, and very little data are available on BTC’s biology, clinical behavior, drug sensitivity, and patient outcomes. Methods: We performed a retrospective observational stu…
View article: Role of Gut-Derived Endotoxins in Porto-Sinusoidal Vascular Disorder: Comparison between Patients with and Without Portal Hypertension
Role of Gut-Derived Endotoxins in Porto-Sinusoidal Vascular Disorder: Comparison between Patients with and Without Portal Hypertension Open
View article: New Relevant Evidence in Cholangiocarcinoma Biology and Characterization
New Relevant Evidence in Cholangiocarcinoma Biology and Characterization Open
Among solid tumors, cholangiocarcinoma (CCA) emerges as one of the most difficult to eradicate. The silent and asymptomatic nature of this tumor, particularly in its early stages, as well as the high heterogeneity at genomic, epigenetic, a…
View article: Supplementary Fig. S4 from Hepatocellular Carcinoma Immune Microenvironment Analysis: A Comprehensive Assessment with Computational and Classical Pathology
Supplementary Fig. S4 from Hepatocellular Carcinoma Immune Microenvironment Analysis: A Comprehensive Assessment with Computational and Classical Pathology Open
Supplementary Fig. S4. Inflamed immunophenotype is predictor for better patient outcome.
View article: Supplementary Fig. S5 from Hepatocellular Carcinoma Immune Microenvironment Analysis: A Comprehensive Assessment with Computational and Classical Pathology
Supplementary Fig. S5 from Hepatocellular Carcinoma Immune Microenvironment Analysis: A Comprehensive Assessment with Computational and Classical Pathology Open
Supplementary Fig. S5. The effect of biopsy procedure on the concordance of immunophenotype classifications between needle biopsy and resection.