Luca Larini
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View article: Telomeric lncRNA TERRA localizes to stress granules in human ALT cells
Telomeric lncRNA TERRA localizes to stress granules in human ALT cells Open
TERRA, the lncRNA derived from the ends of chromosomes, has a number of well-described nuclear roles including telomere maintenance and homeostasis. A growing body of evidence now points at its role in human cells outside of nucleus—it has…
View article: TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in<i>Caenorhabditis elegans</i>
TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in<i>Caenorhabditis elegans</i> Open
Several aspects of telomere biology are regulated by the telomeric repeat-containing RNA TERRA. While TERRA expression is conserved through evolution, species-specific mechanisms regulate its biogenesis and function. Here we report on the …
View article: Computational and experimental analysis of short peptide motifs for enzyme inhibition
Computational and experimental analysis of short peptide motifs for enzyme inhibition Open
The metabolism of living systems involves many enzymes that play key roles as catalysts and are essential to biological function. Searching ligands with the ability to modulate enzyme activities is central to diagnosis and therapeutics. Pe…
View article: Regulation and aggregation of intrinsically disordered peptides
Regulation and aggregation of intrinsically disordered peptides Open
Significance The microtubule-regulating protein tau is a prototypical intrinsically disordered protein (IDP) that plays an important physiological role in the human body; however, aggregates of tau are a pathological hallmark of Alzheimer’…