Luca Massimino
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View article: Spatiotemporal analysis of Crohn’s disease reveals PECAM2 signaling at the basis of the inflammation-to-fibrosis transition
Spatiotemporal analysis of Crohn’s disease reveals PECAM2 signaling at the basis of the inflammation-to-fibrosis transition Open
Background and Aims Crohn’s disease (CD) is a chronic inflammatory disease of the bowel, often complicated by fibrotic strictures, for which medical treatment is lacking, and surgery is commonly required. The mechanisms underlying the prog…
View article: Impact of Non‐Anesthesiologist‐Administered Propofol Sedation for Outpatient Endoscopy in the Healthcare System
Impact of Non‐Anesthesiologist‐Administered Propofol Sedation for Outpatient Endoscopy in the Healthcare System Open
Introduction Non‐anesthesiologist‐administered propofol (NAAP) sedation for outpatient endoscopy has proven to be safe. However, implementing NAAP in Western countries faces challenges, and propofol‐based sedation is still largely administ…
View article: Microbiota-produced immune regulatory bile acid metabolites control central nervous system autoimmunity
Microbiota-produced immune regulatory bile acid metabolites control central nervous system autoimmunity Open
The commensal gut microbiota has a role in the pathogenesis of extra-intestinal autoimmune diseases such as multiple sclerosis (MS) with unknown mechanisms. Deoxycholic acid (DCA) and lithocholic acid (LCA) are secondary bile acid metaboli…
View article: Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era
Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era Open
Barrett’s esophagus (BE) represents a pre-cancerous condition that is characterized by the metaplastic conversion of the squamous esophageal epithelium to a columnar intestinal-like phenotype. BE is the consequence of chronic reflux diseas…
View article: Reaching the therapeutic ceiling in IBD: Can Advanced Combination Treatment (ACT) offer a solution?
Reaching the therapeutic ceiling in IBD: Can Advanced Combination Treatment (ACT) offer a solution? Open
The term Advanced Combination Treatment (ACT) involves the combination of at least two biologics or the use of a biologic with a small molecule drug, each with different mechanisms of action. This narrative review evaluates the current evi…
View article: Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma
Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma Open
Background Anaplastic Large Cell Lymphoma (ALCL) is a rare and aggressive T-cell lymphoma, classified into ALK-positive and ALK-negative subtypes, based on the presence of chromosomal translocations involving the ALK gene. The current stan…
View article: Artificial intelligence: A new tool in the pathologist's armamentarium for the diagnosis of IBD
Artificial intelligence: A new tool in the pathologist's armamentarium for the diagnosis of IBD Open
Inflammatory bowel diseases (IBD) are classified into two entities, namely Crohn's disease (CD) and ulcerative colitis (UC), which differ in disease trajectories, genetics, epidemiological, clinical, endoscopic, and histopathological aspec…
View article: Inflammatory bowel disease genomics, transcriptomics, proteomics and metagenomics meet artificial intelligence
Inflammatory bowel disease genomics, transcriptomics, proteomics and metagenomics meet artificial intelligence Open
Various extrinsic and intrinsic factors such as drug exposures, antibiotic treatments, smoking, lifestyle, genetics, immune responses, and the gut microbiome characterize ulcerative colitis and Crohn's disease, collectively called inflamma…
View article: From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis
From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis Open
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus. EoE shares a common pathogenetic mechanism with other chronic disorders pertaining to the type 2 inflammatory spectrum, such as atopic dermatitis (AD), all…
View article: The Role of Viruses in the Pathogenesis of Immune-Mediated Gastro-Intestinal Diseases
The Role of Viruses in the Pathogenesis of Immune-Mediated Gastro-Intestinal Diseases Open
Immune-mediated gastrointestinal (GI) diseases, including achalasia, celiac disease, and inflammatory bowel diseases, pose significant challenges in diagnosis and management due to their complex etiology and diverse clinical manifestations…
View article: Gene therapy for Dravet syndrome: promises and impact on disease trigger and secondary modifications
Gene therapy for Dravet syndrome: promises and impact on disease trigger and secondary modifications Open
Dravet syndrome is a severe epileptic syndrome that begins during the first year of life of otherwise healthy babies. Over the years, the seizure burden changes, and pathology evolves in strong association with behavioral alterations, incl…
View article: An international multicentre study of <scp>SwiTching</scp> from Intravenous to subcutaneous <scp>inflixiMab</scp> and <scp>vEdolizumab</scp> in inflammatory bowel diseases: The <scp>TIME</scp> study
An international multicentre study of <span>SwiTching</span> from Intravenous to subcutaneous <span>inflixiMab</span> and <span>vEdolizumab</span> in inflammatory bowel diseases: The <span>TIME</span> study Open
Background and Aims Subcutaneous (SC) formulations of infliximab (IFX) and vedolizumab (VDZ) are approved for the treatment of inflammatory bowel diseases (IBDs). Our aim was to evaluate the effectiveness of switching from intravenous (IV)…
View article: Esophageal viral and bacterial microbiome unbalances characterize achalasia
Esophageal viral and bacterial microbiome unbalances characterize achalasia Open
Achalasia is a rare neuromuscular disorder of the esophagus whose pathogenesis is poorly understood. It is characterized by the loss of nerve cells in the esophagus, failure of the lower esophageal sphincter to relax, and impaired esophage…
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View article: Hugging Face's impact on medical applications of artificial intelligence
Hugging Face's impact on medical applications of artificial intelligence Open
In the rapidly evolving field of medical science, multiple applications of artificial Intelligence (AI) have emerged. Until very recently, developing an AI system required a combination of large datasets and advanced computer skills. Each …
View article: The Dual Lens of Endoscopy and Histology in the Diagnosis and Management of Eosinophilic Gastrointestinal Disorders—A Comprehensive Review
The Dual Lens of Endoscopy and Histology in the Diagnosis and Management of Eosinophilic Gastrointestinal Disorders—A Comprehensive Review Open
Eosinophilic Gastrointestinal Disorders (EGIDs) are a group of conditions characterized by abnormal eosinophil accumulation in the gastrointestinal tract. Among these EGIDs, Eosinophilic Esophagitis (EoE) is the most well documented, while…
View article: Prostaglandin D2 synthase controls Schwann cells metabolism
Prostaglandin D2 synthase controls Schwann cells metabolism Open
We previously reported that in the absence of Prostaglandin D2 synthase (L–PGDS) peripheral nerves are hypomyelinated in development and that with aging they present aberrant myelin sheaths. We now demonstrate that L–PGDS expressed in Schw…
View article: Idiopathic erythrocytosis: a germline disease?
Idiopathic erythrocytosis: a germline disease? Open
Polycythemia Vera (PV) is typically caused by V617F or exon 12 JAK2 mutations. Little is known about Polycythemia cases where no JAK2 variants can be detected, and no other causes identified. This condition is defined as idiopathic erythro…
View article: ECCO Grant Investigating the role of gut eukaryotic virome in contributing to colorectal cancer carcinogenesis
ECCO Grant Investigating the role of gut eukaryotic virome in contributing to colorectal cancer carcinogenesis Open
Background and Aims Eukaryotic-targeting viruses have recently attracted considerable interest in gastrointestinal diseases such as ulcerative colitis (UC) and colorectal cancer (CRC)1–3, the fourth leading cause of cancer death in the wor…
View article: P1036 Persistence of biologics and advanced small molecules in 4th, 5th and 6th line of therapy for inflammatory bowel disease: a cross-sectional retrospective study
P1036 Persistence of biologics and advanced small molecules in 4th, 5th and 6th line of therapy for inflammatory bowel disease: a cross-sectional retrospective study Open
Background The choice of treatment for inflammatory bowel disease (IBD) with multiple prior drug failures, also known as difficult-to-treat (D2T) IBD, is an increasing challenge. We assessed the persistence of biologics and advanced small …
View article: P101 Investigating the role of gut eukaryotic virome in contributing to colorectal cancer carcinogenesis
P101 Investigating the role of gut eukaryotic virome in contributing to colorectal cancer carcinogenesis Open
Background Eukaryotic-targeting viruses have recently attracted interest in gastrointestinal diseases such as ulcerative colitis (UC) and colorectal cancer (CRC). UC and CRC share several factors influencing their etiogenesis, including in…
View article: Microbiota-Produced Immune Regulatory Bile Acid Metabolites Prevent Central Nervous System Autoimmunity
Microbiota-Produced Immune Regulatory Bile Acid Metabolites Prevent Central Nervous System Autoimmunity Open
View article: P710 Prevalence, Characteristics and Management of Patients with Difficult-To-Treat Inflammatory Bowel Disease: A Cross-Sectional Study From a Tertiary Referral Center
P710 Prevalence, Characteristics and Management of Patients with Difficult-To-Treat Inflammatory Bowel Disease: A Cross-Sectional Study From a Tertiary Referral Center Open
Background Difficult-to-treat (D2T) inflammatory bowel disease (IBD) is defined by lack or loss of response to advanced treatments with 2 or more mechanisms of action (MoA), Crohn’s (CD) recurrence after 2 resections, chronic antibiotic re…
View article: P073 Enhancing the MFSD2A protein for the treatment of colitis-associated cancer: novel insights for pathogenesis and treatment
P073 Enhancing the MFSD2A protein for the treatment of colitis-associated cancer: novel insights for pathogenesis and treatment Open
Background The intrinsic connection between inflammation and tumor promotion is well characterized and is a key pathogenic event in patients with colorectal cancer (CRC). A small fraction of patients with CRC suffers from genetic predispos…
View article: P057 Caudovirales may trigger molecular mimicry mechanisms in Crohn’s Disease
P057 Caudovirales may trigger molecular mimicry mechanisms in Crohn’s Disease Open
Background The gut virome is known to play a role in the development of Crohn's disease (CD), a type of Inflammatory Bowel Disease (IBD). Several years ago, Norman and colleagues observed an expansion of Caudovirales linked to CD pathogene…
View article: Microbiota profiling in esophageal diseases: Novel insights into molecular staining and clinical outcomes
Microbiota profiling in esophageal diseases: Novel insights into molecular staining and clinical outcomes Open
Gut microbiota is recognized nowadays as one of the key players in the development of several gastro-intestinal diseases. The first studies focused mainly on healthy subjects with staining of main bacterial species via culture-based techni…
View article: Gut virome in inflammatory bowel disease and beyond
Gut virome in inflammatory bowel disease and beyond Open
Objective The gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part of the microbiota. The virome coexists with the other components of the microbiota and with the host in a dynamic equilibri…
View article: Gut Dysbiosis in Irritable Bowel Syndrome: A Narrative Review on Correlation with Disease Subtypes and Novel Therapeutic Implications
Gut Dysbiosis in Irritable Bowel Syndrome: A Narrative Review on Correlation with Disease Subtypes and Novel Therapeutic Implications Open
Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits. It can be subclassified in different subtypes according to the main clinical manifestation…
View article: Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review
Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review Open
Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, imposing significant burdens on healthcare systems and patient quality of life. Interestingly, around 20% of endometriosi…
View article: P1235: INVESTIGATION OF THE CO-MUTATIONAL LANDSCAPE OF ALK-POSITIVE ALCL
P1235: INVESTIGATION OF THE CO-MUTATIONAL LANDSCAPE OF ALK-POSITIVE ALCL Open
Topic: 20. Lymphoma Biology & Translational Research Background: Anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphoma (ALCL) is an aggressive lymphoma characterized by expression of the NPM::ALK fusion tyrosine kinase e…