Luca Occhigrossi
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View article: Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis Open
The receptor interacting protein kinase 3 (RIPK3) is the main player in the activation of necroptosis, a pro-inflammatory regulated cell death modality induced by many different stimuli. RIPK3 is epigenetically regulated by DNA methylation…
View article: Epigenetic modulation of RIPK3 by Transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
Epigenetic modulation of RIPK3 by Transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis Open
The receptor interacting protein kinase 3 (RIPK 3) is the main player in the activation of necroptosis, a pro-inflammatory regulated cell death modality induced by many different stimuli. RIPK3 is epigenetically regulated by DNA methylatio…
View article: Epigenetic modulation of RIPK3 by Transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
Epigenetic modulation of RIPK3 by Transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis Open
The receptor interacting protein kinase 3 (RIPK 3) is the main player in the activation of necroptosis, a pro-inflammatory regulated cell death modality induced by many different stimuli. RIPK3 is epigenetically regulated by DNA methylatio…
View article: Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases
Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases Open
Aging is a gradual and irreversible physiological process that significantly increases the risks of developing a variety of pathologies, including neurodegenerative, cardiovascular, metabolic, musculoskeletal, and immune system diseases. M…
View article: Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma
Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma Open
View article: The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis Open
Cystic fibrosis (CF) is a rare autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation is F508del-CFTR (ΔF) which leads the encoded ion channel toward…
View article: Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme
Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme Open
One of the major mysteries in science is how it is possible to pack the cellular chromatin with a total length of over 1 m, into a small sphere with a diameter of 5 mm “the nucleus”, and even more difficult to envisage how to make it funct…
View article: Cysteamine/Cystamine Exert Anti-Mycobacterium abscessus Activity Alone or in Combination with Amikacin
Cysteamine/Cystamine Exert Anti-Mycobacterium abscessus Activity Alone or in Combination with Amikacin Open
Host-directed therapies are emerging as a promising tool in the curing of difficult-to-treat infections, such as those caused by drug-resistant bacteria. In this study, we aim to test the potential activity of the FDA- and EMA-approved dru…
View article: Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells
Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells Open
View article: The Multifaceted Role of HSF1 in Pathophysiology: Focus on Its Interplay with TG2
The Multifaceted Role of HSF1 in Pathophysiology: Focus on Its Interplay with TG2 Open
The cellular environment needs to be strongly regulated and the maintenance of protein homeostasis is crucial for cell function and survival. HSF1 is the main regulator of the heat shock response (HSR), the master pathway required to maint…
View article: Transglutaminase 2 Regulates Innate Immunity by Modulating the STING/TBK1/IRF3 Axis
Transglutaminase 2 Regulates Innate Immunity by Modulating the STING/TBK1/IRF3 Axis Open
We have recently shown that type 2 transglutaminase (TG2) plays a key role in the host’s inflammatory response during bacterial infections. In this study, we investigated whether the enzyme is involved in the regulation of the STING pathwa…
View article: Transglutaminase Type 2 regulates the Wnt/β-catenin pathway in vertebrates
Transglutaminase Type 2 regulates the Wnt/β-catenin pathway in vertebrates Open
View article: Transglutaminase Type 2 is Involved in the Hematopoietic Stem Cells Homeostasis
Transglutaminase Type 2 is Involved in the Hematopoietic Stem Cells Homeostasis Open
Type 2 transglutaminase (TG2) is a multifunctional protein involved in various biological processes playing a key regulatory role in cell homeostasis such as cell death and autophagy. New evidence is emerging that support an important role…
View article: Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75
Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75 Open
Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 7…
View article: TG2 regulates the heat‐shock response by the post‐translational modification of HSF1
TG2 regulates the heat‐shock response by the post‐translational modification of HSF1 Open