Luca Steardo
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View article: Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer’s disease
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer’s disease Open
Alzheimer’s disease (AD), a multifactorial neurodegenerative disorder, is characterized by metabolic deficiency, neuroinflammation, and synaptic impairment. Cerebral energy homeostasis is regulated by the astrocyte-neuron metabolic couplin…
View article: Post‐COVID‐19 neuropsychiatric syndrome: Is maladaptive glial recovery to blame?
Post‐COVID‐19 neuropsychiatric syndrome: Is maladaptive glial recovery to blame? Open
Prolonged recovery and delayed polysymptomatic complications distinguish the COVID-19, caused by SARS-COV-2 viral infection, from other flu-like illnesses.1 A growing number of patients report symptoms, including early- and late-onset neur…
View article: Psychiatric face of COVID-19
Psychiatric face of COVID-19 Open
View article: Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer’s disease by exerting anti-inflammatory and neuroprotective effects
Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer’s disease by exerting anti-inflammatory and neuroprotective effects Open
View article: Palmitoylethanolamide Dampens Reactive Astrogliosis and Improves Neuronal Trophic Support in a Triple Transgenic Model of Alzheimer’s Disease:<i>In Vitro</i>and<i>In Vivo</i>Evidence
Palmitoylethanolamide Dampens Reactive Astrogliosis and Improves Neuronal Trophic Support in a Triple Transgenic Model of Alzheimer’s Disease:<i>In Vitro</i>and<i>In Vivo</i>Evidence Open
Alzheimer’s disease (AD) is a neurodegenerative disorder responsible for the majority of dementia cases in elderly people. It is widely accepted that the main hallmarks of AD are not only senile plaques and neurofibrillary tangles but also…
View article: Diet-induced obesity and diet-resistant rats: differences in the rewarding and anorectic effects of d-amphetamine
Diet-induced obesity and diet-resistant rats: differences in the rewarding and anorectic effects of d-amphetamine Open
View article: S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells
S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells Open
S100 calcium-binding protein B (S100B) is highly expressed in glioma cells and promotes cancer cell survival via inhibition of the p53 protein. In melanoma cells, this S100B-p53 interaction is known to be inhibited by pentamidine isethiona…
View article: S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease
S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease Open
Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease. The use of phar…