Jorge A. Pereira
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View article: Dengue in Brazil: an ecological study of burden, hospitalizations, and mortality trends (2019–2024)
Dengue in Brazil: an ecological study of burden, hospitalizations, and mortality trends (2019–2024) Open
Dengue is the most widespread arboviral disease globally, affecting over 100 countries; Brazil accounts for 83% of cases in the Americas. This is an observational, cross-sectional ecological study encompassed all 27 Brazilian federative un…
View article: Dengue in Brazil: An Ecological Study of Burden, Hospitalizations, and Mortality Trends (2019–2024)
Dengue in Brazil: An Ecological Study of Burden, Hospitalizations, and Mortality Trends (2019–2024) Open
Dengue is the most widespread arboviral disease globally, affecting over 100 countries, with Brazil accounting for 83% of cases in the Americas. This high prevalence places a substantial burden on the healthcare system. This is an observat…
View article: Extreme shape coexistence observed in 70Co
Extreme shape coexistence observed in 70Co Open
View article: Extreme Shape Coexistence Observed in $^{70}$Co
Extreme Shape Coexistence Observed in $^{70}$Co Open
The shape of the atomic nucleus is a property which underpins our understanding of nuclear systems, impacts the limits of nuclear existence, and enables probes of physics beyond the Standard Model. Nuclei can adopt a variety of shapes, inc…
View article: Spatial profiling identifies regionally distinct microenvironments and targetable immunosuppressive mechanisms in pediatric osteosarcoma pulmonary metastases
Spatial profiling identifies regionally distinct microenvironments and targetable immunosuppressive mechanisms in pediatric osteosarcoma pulmonary metastases Open
Osteosarcoma is the most common malignant bone tumor in young patients and remains a significant clinical challenge, particularly in the context of metastatic disease. Despite extensive documentation of genomic alterations in osteosarcoma,…
View article: DIÁLOGO COM LIDERANÇAS INDÍGENAS SOBRE AS ESPECIFICIDADES SOCIOCULTURAIS DO CICLO GRAVÍDICO PUERPERAL DE MULHERES INDÍGENAS: RELATO DE EXPERIÊNCIA
DIÁLOGO COM LIDERANÇAS INDÍGENAS SOBRE AS ESPECIFICIDADES SOCIOCULTURAIS DO CICLO GRAVÍDICO PUERPERAL DE MULHERES INDÍGENAS: RELATO DE EXPERIÊNCIA Open
View article: FORMAÇÃO DOCENTE E O LETRAMENTO RACIAL COMO MECANISMO PARA UMA EDUCAÇÃO ANTIRRACISTA
FORMAÇÃO DOCENTE E O LETRAMENTO RACIAL COMO MECANISMO PARA UMA EDUCAÇÃO ANTIRRACISTA Open
Esta pesquisa teve como objetivo analisar como a formação docente, especialmente por meio do letramento racial, pode contribuir para a promoção de uma educação antirracista nas escolas. A metodologia adotada foi uma revisão bibliográfica, …
View article: ASPECTOS SOCIODEMOGRÁFICOS DE DOENÇAS TROPICAIS NEGLIGENCIADAS CAUSADAS POR PROTOZOÁRIOS NO ESTADO DO PARÁ (2018-2022)
ASPECTOS SOCIODEMOGRÁFICOS DE DOENÇAS TROPICAIS NEGLIGENCIADAS CAUSADAS POR PROTOZOÁRIOS NO ESTADO DO PARÁ (2018-2022) Open
As doenças tropicais negligenciadas (DTN) são enfermidades que assolam gerações há séculos no mundo todo, e são caracterizadas por serem endêmicas de regiões com baixo desenvolvimento socioeconômico, como países da Ásia, África, Oriente Mé…
View article: The <scp>E3</scp> ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system
The <span>E3</span> ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system Open
Ubiquitination is a major post‐translational regulatory mechanism that tunes numerous aspects of ubiquitinated target proteins, including localization, stability, and function. During differentiation and myelination, Oligodendrocytes (OLs)…
View article: Ral GTPases are critical regulators of spinal cord myelination and homeostasis
Ral GTPases are critical regulators of spinal cord myelination and homeostasis Open
View article: [IoTaIS 2021 Front cover]
[IoTaIS 2021 Front cover] Open
The promise of Connected and Automated Mobility (CAM) are Safer (enhanced road safety), More Efficient (lower emissions and reduced congestion) and Connected (infotainment) Rides, not forgetting a significant impact on productivity, jobs a…
View article: JPA volume 95 issue 6 Cover and Back matter
JPA volume 95 issue 6 Cover and Back matter Open
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View article: Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)
Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT) Open
Peripheral nerves are organ-like structures containing diverse cell types to optimize function. This interactive assembly includes mostly axon-associated Schwann cells, but also endothelial cells of supporting blood vessels, immune system-…
View article: Author response: Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)
Author response: Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT) Open
View article: Mesenchymal stem cells derivatives as a novel and potential therapeutic approach to treat diabetic foot ulcers
Mesenchymal stem cells derivatives as a novel and potential therapeutic approach to treat diabetic foot ulcers Open
Summary Diabetic foot ulcer morbidity and mortality are dramatically increasing worldwide, reinforcing the urgency to propose more effective interventions to treat such a devastating condition. Previously, using a diabetic mouse model, we …
View article: Mice carrying an analogous heterozygous dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy
Mice carrying an analogous heterozygous dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy Open
Some mutations affecting dynamin 2 (DNM2) can cause dominantly inherited Charcot–Marie–Tooth (CMT) neuropathy. Here, we describe the analysis of mice carrying the DNM2 K562E mutation which has been associated with dominant-intermediate CMT…
View article: Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system
Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system Open
Small GTPases of the Rho and Ras families are important regulators of Schwann cell biology. The Ras-like GTPases RalA and RalB act downstream of Ras in malignant peripheral nerve sheath tumors. However, the physiological role of Ral protei…
View article: CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes
CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes Open
Oligodendrocytes (OLs) support neurons and signal transmission in the central nervous system (CNS) by enwrapping axons with myelin, a lipid-rich membrane structure. We addressed the significance of fatty acid (FA) synthesis in OLs by deple…
View article: Author response: CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes
Author response: CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes Open
View article: Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function
Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function Open
Myelination requires extensive plasma membrane rearrangements, implying that molecules controlling membrane dynamics play prominent roles. The large GTPase dynamin 2 (DNM2) is a well-known regulator of membrane remodeling, membrane fission…
View article: Author response: Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function
Author response: Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function Open
View article: The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells
The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells Open
Proper function of the nervous system depends on myelination. In peripheral nerves, Schwann cells (SCs) myelinate axons and the miRNA biogenesis pathway is required for developmental myelination and myelin maintenance. However, regulatory …
View article: mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation
mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation Open
Schwann cells (SCs) are endowed with a remarkable plasticity. When peripheral nerves are injured, SCs dedifferentiate and acquire new functions to coordinate nerve repair as so-called repair SCs. Subsequently, SCs redifferentiate to remyel…
View article: De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination
De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination Open
Myelination calls for a remarkable surge in cell metabolism to facilitate lipid and membrane production. Endogenous fatty acid (FA) synthesis represents a potentially critical process in myelinating glia. Using genetically modified mice, w…
View article: Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system Open
Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position. We have shown previously that loss of mTORC1 function in Schwann cells (SCs) hampers myelination. …
View article: Author response: Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
Author response: Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Myelination is a biosynthetic…
View article: Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway Open
View article: The Lin28/let-7 axis is critical for myelination in the peripheral nervous system
The Lin28/let-7 axis is critical for myelination in the peripheral nervous system Open
View article: HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins
HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins Open
The pathogenesis of peripheral neuropathies in adults is linked to maintenance mechanisms that are not well understood. Here, we elucidate a novel critical maintenance mechanism for Schwann cell (SC)-axon interaction. Using mouse genetics,…