Lucas Armbrecht
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View article: MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies
MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies Open
View article: Microbial factories: monitoring vitamin B<sub>2</sub> production by <i>Escherichia coli</i> in microfluidic cultivation chambers
Microbial factories: monitoring vitamin B<sub>2</sub> production by <i>Escherichia coli</i> in microfluidic cultivation chambers Open
We present a microfluidic chamber system for bacterial cultivation enabling dynamic studies of a secreted product of the bacterial biosynthesis.
View article: Quantification of Protein Secretion from Circulating Tumor Cells in Microfluidic Chambers
Quantification of Protein Secretion from Circulating Tumor Cells in Microfluidic Chambers Open
Cancer cells can be released from a cancerous lesion and migrate into the circulatory system, from whereon they may form metastases at distant sites. Today, it is possible to infer cancer progression and treatment efficacy by determining t…
View article: Single-cell protein profiling in microchambers with barcoded beads
Single-cell protein profiling in microchambers with barcoded beads Open
Single-cell profiling provides insights into cellular behaviour that macroscale cell cultures and bulk measurements cannot reveal. In the context of personalized cancer treatment, the profiling of individual tumour cells may lead to higher…
View article: In silico design and optimization of selective membranolytic anticancer peptides
In silico design and optimization of selective membranolytic anticancer peptides Open
View article: Microfluidics for Functional Analysis of Circulating Tumor Cells
Microfluidics for Functional Analysis of Circulating Tumor Cells Open
View article: Characterisation of anticancer peptides at the single-cell level
Characterisation of anticancer peptides at the single-cell level Open
Cell response heterogeneity impedes success in chemotherapy outcome as well as hampers the development of efficacious anticancer therapeutics. We present a microfluidic screening platform capable of high-throughput monitoring of heterogene…
View article: Multianalyte Antibiotic Detection on an Electrochemical Microfluidic Platform
Multianalyte Antibiotic Detection on an Electrochemical Microfluidic Platform Open
The excessive use of antibiotics in human and veterinary medicine causes the emergence of multidrug resistant bacteria. In this context, the surveillance of many different antibiotics provokes a worldwide challenge. Hence, fast and versati…
View article: Designed miniaturization of microfluidic biosensor platforms using the stop-flow technique
Designed miniaturization of microfluidic biosensor platforms using the stop-flow technique Open
Here, we present a novel approach to increase the degree of miniaturization as well as the sensitivity of biosensor platforms by the optimization of microfluidic stop-flow techniques independent of the applied detection technique (e.g. ele…
View article: Electrochemical Microfluidic Platform for Simultaneous Multi-analyte Detection
Electrochemical Microfluidic Platform for Simultaneous Multi-analyte Detection Open
We present an electrochemical lab-on-a-chip (LOC) platform for the simultaneous detection of up to four different analytes. The possibility to separately immobilize different assays in a channel network, without active valves, was successf…
View article: Self-assembled magnetic bead chains for sensitivity enhancement of microfluidic electrochemical biosensor platforms
Self-assembled magnetic bead chains for sensitivity enhancement of microfluidic electrochemical biosensor platforms Open
We present a new approach to increase the sensitivity of magnetic bead-based microfluidic biosensor platforms with laminated low-cost soft-magnetic lattices.