Lucas D. Warma
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View article: Glandular trichome rupture in tomato plants is an ultra-fast and sensitive defense mechanism against insects
Glandular trichome rupture in tomato plants is an ultra-fast and sensitive defense mechanism against insects Open
Trichomes, specialized hair-like structures on the surfaces of many plants, play a crucial role in defense against herbivorous insects. We investigated the biomechanics of type VI glandular trichome rupture in cultivated tomato (Solanum ly…
View article: Supplementary Table S5 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Table S5 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Sequences for forward (FWD) and reverse (REV) primers used in qRT-PCR assays
View article: Supplementary Materials and Methods 1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Materials and Methods 1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Materials and Methods, clean copy version
View article: Supplementary Table S3 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Table S3 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Immune subsets and their associated cell surface markers used for gating in flow cytometric analysis
View article: Figure S9 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S9 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S9: Human TNBC cell lines MDA-MB-231 and MDA-MB-468 were injected in the T4 mammary fat pad of 12 week old nude mice. When tumors reached size of 100mm3, mice were randomized in Vehicle and AZD9668 100mg/kg groups. Mic…
View article: Supplementary Data 1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Data 1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
The file contains NMR spectrometry, LC-MS and HPLC analyses was performed to confirm the purity of and the metabolites profile of AZD9668
View article: Data from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Data from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Metastatic disease remains the leading cause of death due to cancer, yet the mechanism(s) of metastasis and its timely detection remain to be elucidated. Neutrophil elastase (NE), a serine protease secreted by neutrophils, is a crucial med…
View article: Figure S5 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S5 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S5: Reverse Phase Protein Array (RPPA) analysis was conducted on TAN negative and TAN positive patient samples described in Figure 1, using 174 validated antibodies. The mean of the normalized, linear RPPA values are r…
View article: Figure S9 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S9 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S9: Human TNBC cell lines MDA-MB-231 and MDA-MB-468 were injected in the T4 mammary fat pad of 12 week old nude mice. When tumors reached size of 100mm3, mice were randomized in Vehicle and AZD9668 100mg/kg groups. Mic…
View article: Figure S6 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S6 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S6: (A) Fraction of immune vs. non-immune (primarily epithelial) cells from PyMT tumors used for RNA-seq. A small fraction of tumor tissues was isolated for this QC analysis, including CD45 fraction as presented in thi…
View article: Figure S7 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S7 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S7: Recurrence-free survival (A) and overall survival (C) for each individual gene used in the METABRIC patient cohort signature and progression-free survival (B) and overall survival (D) used in the and TCGA patient c…
View article: Supplementary Table S4 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Table S4 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
List of antibodies used in all the flow cytometric analysis
View article: Figure S8 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S8 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S8: (A) PK data for AZD9668, when administered by intraperitoneal (I.P.) injection at a concentration of 100mg/kg. N=3 mice were used per timepoint, and the t1/2 of the drug was calculated to 2.16 hours. (B) Specificit…
View article: Figure S2 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S2 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S2: (A) Percentage of tumor-free mice in PyMT NE+/+ (N=30) and PyMT NE-/- (N=21) mice, between 12-14 weeks of age. (B) Total tumor mass, (C) number of glands with tumors per mouse and (D) doubling time of tumors at end…
View article: Supplementary Table S1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Table S1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Comparison of Clinical and Pathological Characteristics of Breast Cancer Patients as a Function of Tumor Associated Neutrophils (TAN) status
View article: Supplementary Table S2 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Table S2 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Multivariate Cox Proportional Hazards Analysis of Clinicopathologic Variables’ Influence in Breast Cancer RFS (n=242)
View article: Supplementary Table S3 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Table S3 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Immune subsets and their associated cell surface markers used for gating in flow cytometric analysis
View article: Figure S4 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S4 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S4: A focused T-cell subset of immune cells composed of naïve, memory and regulatory T-cell markers was interrogated in 12-week old PyMT NE+/+ (N=4) and PyMT NE- /- (N=3) mice. The percentage of each cell type (normali…
View article: Figure S6 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S6 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S6: (A) Fraction of immune vs. non-immune (primarily epithelial) cells from PyMT tumors used for RNA-seq. A small fraction of tumor tissues was isolated for this QC analysis, including CD45 fraction as presented in thi…
View article: Figure S8 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S8 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S8: (A) PK data for AZD9668, when administered by intraperitoneal (I.P.) injection at a concentration of 100mg/kg. N=3 mice were used per timepoint, and the t1/2 of the drug was calculated to 2.16 hours. (B) Specificit…
View article: Supplementary Table S4 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Table S4 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
List of antibodies used in all the flow cytometric analysis
View article: Figure S5 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S5 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S5: Reverse Phase Protein Array (RPPA) analysis was conducted on TAN negative and TAN positive patient samples described in Figure 1, using 174 validated antibodies. The mean of the normalized, linear RPPA values are r…
View article: Figure S3 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S3 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S3: The immune milieu is unchanged between PyMT tumor bearing NE+/+ and NE-/- mice. A basic panel of immune cells composed of myeloid cells (neutrophils, monocytes, and macrophages), T-cells and B-cells was interrogate…
View article: Figure S1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S1: (A) Fraction of CD45-ve cells in the bone marrows isolated from PyMT NE+/+ (N=5) and PyMT NE-/- (N=5), used in Supplementary Figure S2. Gating strategies for the CD45+ and CD45- cells is shown in Supplementary Figu…
View article: Figure S3 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S3 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S3: The immune milieu is unchanged between PyMT tumor bearing NE+/+ and NE-/- mice. A basic panel of immune cells composed of myeloid cells (neutrophils, monocytes, and macrophages), T-cells and B-cells was interrogate…
View article: Figure S10 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S10 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S10: Gating strategy used to identify myeloid, lymphoid and B-cell populations for the experiment described in Supplementary Figure S2. All analyses were conducted on FlowJo and statistical analyses were done on GraphP…
View article: Supplementary Data 1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Data 1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
The file contains NMR spectrometry, LC-MS and HPLC analyses was performed to confirm the purity of and the metabolites profile of AZD9668
View article: Supplementary Table S1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Supplementary Table S1 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Comparison of Clinical and Pathological Characteristics of Breast Cancer Patients as a Function of Tumor Associated Neutrophils (TAN) status
View article: Figure S10 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S10 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S10: Gating strategy used to identify myeloid, lymphoid and B-cell populations for the experiment described in Supplementary Figure S2. All analyses were conducted on FlowJo and statistical analyses were done on GraphP…
View article: Figure S2 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis
Figure S2 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis Open
Supplementary Figure S2: (A) Percentage of tumor-free mice in PyMT NE+/+ (N=30) and PyMT NE-/- (N=21) mice, between 12-14 weeks of age. (B) Total tumor mass, (C) number of glands with tumors per mouse and (D) doubling time of tumors at end…