Lucas F. Maciel
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View article: Metformin in non-diabetic patients with autosomal dominant polycystic kidney disease: a systematic review and meta-analysis of randomized controlled trials
Metformin in non-diabetic patients with autosomal dominant polycystic kidney disease: a systematic review and meta-analysis of randomized controlled trials Open
View article: Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment
Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment Open
View article: Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial
Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial Open
View article: Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States, Progression and Metastasis
Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States, Progression and Metastasis Open
Cancer cells display distinct, recurrent phenotypic cell states. Metastatic spreading correlates with tumor cell state evolution. However, the molecular mechanisms underlying metastasis remain elusive. Here, we demonstrate that the quantit…
View article: A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma Open
View article: Long non-coding RNAs are essential for Schistosoma mansoni pairing-dependent adult worm homeostasis and fertility
Long non-coding RNAs are essential for Schistosoma mansoni pairing-dependent adult worm homeostasis and fertility Open
The trematode parasite Schistosoma mansoni causes schistosomiasis, which affects over 200 million people worldwide. Schistosomes are dioecious, with egg laying depending on the females’ obligatory pairing with males. Long non-coding RNAs (…
View article: Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides
Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides Open
View article: Assessment of reference genes at six different developmental stages of Schistosoma mansoni for quantitative RT-PCR
Assessment of reference genes at six different developmental stages of Schistosoma mansoni for quantitative RT-PCR Open
Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is the most used, fast, and reproducible method to confirm large-scale gene expression data. The use of stable reference genes for the normalization of RT-qPC…
View article: Exploring metal ion metabolisms to improve xylose fermentation in <i>Saccharomyces cerevisiae</i>
Exploring metal ion metabolisms to improve xylose fermentation in <i>Saccharomyces cerevisiae</i> Open
Summary The development of high‐performance xylose‐fermenting yeast is essential to achieve feasible conversion of biomass‐derived sugars in lignocellulose‐based biorefineries. However, engineered C5‐strains of Saccharomyces cerevisiae sti…
View article: Gut microbiome of capybara, the Amazon master of the grasses, harbors unprecedented enzymatic strategies for plant glycans breakdown
Gut microbiome of capybara, the Amazon master of the grasses, harbors unprecedented enzymatic strategies for plant glycans breakdown Open
Background: Plant biomass is a promising feedstock to replace fossil-based products including fuels, chemicals and materials. However, the high resistance of plant biomass to either physicochemical or biological deconstruction has been ham…
View article: Long non-coding RNA levels can be modulated by 5-azacytidine in Schistosoma mansoni
Long non-coding RNA levels can be modulated by 5-azacytidine in Schistosoma mansoni Open
View article: Gut Microbiome of the Amazon Master of the Grasses Harbors Unprecedented Enzymatic Strategies for Plant Glycans Breakdown
Gut Microbiome of the Amazon Master of the Grasses Harbors Unprecedented Enzymatic Strategies for Plant Glycans Breakdown Open
BackgroundPlant biomass is a promising feedstock to replace fossil-based products including fuels, chemicals and materials. However, the high resistance of plant biomass to either physicochemical or biological deconstruction has been hampe…
View article: Dynamic Expression of Long Non-Coding RNAs Throughout Parasite Sexual and Neural Maturation in Schistosoma Japonicum
Dynamic Expression of Long Non-Coding RNAs Throughout Parasite Sexual and Neural Maturation in Schistosoma Japonicum Open
Schistosoma japonicum is a flatworm that causes schistosomiasis, a neglected tropical disease. S. japonicum RNA-Seq analyses has been previously reported in the literature on females and males obtained during sexual maturation from 14 to 2…
View article: Identificação e anotação de RNAs longos não-codificantes em Schistosoma mansoni e Schistosoma japonicum
Identificação e anotação de RNAs longos não-codificantes em Schistosoma mansoni e Schistosoma japonicum Open
\n Os RNAs longos não-codificantes (lncRNAs) (> 200 nt) são expressos em níveis inferiores aos dos RNAs mensageiros (mRNAs) e, em todas as espécies modelo eucarióticas onde foram caracterizados, são transcritos a partir de milhares de dife…
View article: Weighted Gene Co-Expression Analyses Point to Long Non-Coding RNA Hub Genes at Different Schistosoma mansoni Life-Cycle Stages
Weighted Gene Co-Expression Analyses Point to Long Non-Coding RNA Hub Genes at Different Schistosoma mansoni Life-Cycle Stages Open
Long non-coding RNAs (lncRNAs) (>200 nt) are expressed at levels lower than those of the protein-coding mRNAs, and in all eukaryotic model species where they have been characterized, they are transcribed from thousands of different genomic…
View article: Jack bean urease modulates neurotransmitter release at insect neuromuscular junctions
Jack bean urease modulates neurotransmitter release at insect neuromuscular junctions Open
JBU (0.28 mg/animal/day) in Locusta migratoria 2nd instar through feeding and injection did not induce lethality, although it did result in a reduction of 20% in the weight gain at the end of 168 h (n = 9, p ≤ 0.05). JBU (0.014 and 0.14 mg…
View article: De novo Assembly and Annotation of the Antarctic Alga Prasiola crispa Transcriptome
De novo Assembly and Annotation of the Antarctic Alga Prasiola crispa Transcriptome Open
sponsorship: This work was supported by the National Council for Scientific and Technological Development (CNPq-Brazil), the Coordination for the Improvement of Higher Education Personnel (CAPES-Brazil), the Fundacao de Amparo a Pesquisa d…
View article: Imunogenicidade da proteína M recombinante de Streptococcus equi subsp. equi coadministrada com um adjuvante molecular
Imunogenicidade da proteína M recombinante de Streptococcus equi subsp. equi coadministrada com um adjuvante molecular Open
The strangles is an infectious disease that affects horses from all ages and causes important economic losses in the equine-related business. The aim of this work was to evaluate the immunogenicity of the recombinant M protein from Strepto…
View article: Immunogenicity of recombinant M protein of Streptococcus equi subsp. equi co administered with a molecular adjuvant
Immunogenicity of recombinant M protein of Streptococcus equi subsp. equi co administered with a molecular adjuvant Open
The strangles is an infectious disease that affects horses from all ages and causes important economic losses in the equine-related business. The aim of this work was to evaluate the immunogenicity of the recombinant M protein from Strepto…