Lucas J. Liu
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View article: Change in platelet and leukocyte counts and hospital mortality in adults with acute kidney injury receiving continuous renal replacement therapy
Change in platelet and leukocyte counts and hospital mortality in adults with acute kidney injury receiving continuous renal replacement therapy Open
View article: TrajSurv: Learning Continuous Latent Trajectories from Electronic Health Records for Trustworthy Survival Prediction
TrajSurv: Learning Continuous Latent Trajectories from Electronic Health Records for Trustworthy Survival Prediction Open
Trustworthy survival prediction is essential for clinical decision making. Longitudinal electronic health records (EHRs) provide a uniquely powerful opportunity for the prediction. However, it is challenging to accurately model the continu…
View article: BlotDx: A deep learning tool for Western blot-based diagnostics
BlotDx: A deep learning tool for Western blot-based diagnostics Open
Background Western blot (WB) is the gold standard for herpes simplex virus (HSV-1/HSV-2) serology but requires manual interpretation by trained laboratory personnel, which is time-consuming and variable. Automating this process could impro…
View article: Epidemiology of sepsis-associated acute kidney injury in the ICU with contemporary consensus definitions
Epidemiology of sepsis-associated acute kidney injury in the ICU with contemporary consensus definitions Open
View article: Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data
Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data Open
Background Fluid balance gap (FBgap—prescribed vs. achieved) is associated with hospital mortality. Downtime is an important quality indicator for the delivery of continuous renal replacement therapy (CRRT). We examined the association of …
View article: IL-17A Levels and Progression of Kidney Disease Following Hospitalization with and without Acute Kidney Injury
IL-17A Levels and Progression of Kidney Disease Following Hospitalization with and without Acute Kidney Injury Open
Key Points IL-17A was higher in patients with AKI versus without AKI during hospitalization and up to 1-year postdischarge. IL-17A was higher in patients with progression of kidney disease but not independently associated with subsequent p…
View article: Effect modification of dosing strategy (AUC or trough) on AKI associated with vancomycin in combination with piperacillin/tazobactam or cefepime and meropenem
Effect modification of dosing strategy (AUC or trough) on AKI associated with vancomycin in combination with piperacillin/tazobactam or cefepime and meropenem Open
Piperacillin-tazobactam (TZP), cefepime (FEP), or meropenem (MEM) and vancomycin (VAN) are commonly used in combination for sepsis. Studies have shown an increased risk of acute kidney injury (AKI) with TZP and VAN compared to FEP or MEM. …
View article: Evaluation of Clinical and Machine Data of Critically Ill Adult COVID Patients with Acute Kidney Injury Exposed to Enhanced Hemoadsorption during CRRT
Evaluation of Clinical and Machine Data of Critically Ill Adult COVID Patients with Acute Kidney Injury Exposed to Enhanced Hemoadsorption during CRRT Open
Introduction: The FDA authorized the emergency use of enhanced hemoadsorption with oXiris in critically ill adult COVID patients with respiratory failure or severe disease to reduce inflammation. In this study, we evaluated c…
View article: Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US
Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US Open
View article: Artificial Intelligence in Continuous Kidney Replacement Therapy
Artificial Intelligence in Continuous Kidney Replacement Therapy Open
Introduction Over the past decade, artificial intelligence (AI) through machine learning (ML) has been increasingly used in health care applications. The use of AI/ML to enhance the provision of continuous kidney replacement therapy (CKRT)…
View article: KIT-LSTM: Knowledge-guided Time-aware LSTM for Continuous Clinical Risk Prediction
KIT-LSTM: Knowledge-guided Time-aware LSTM for Continuous Clinical Risk Prediction Open
Rapid accumulation of temporal Electronic Health Record (EHR) data and recent advances in deep learning have shown high potential in precisely and timely predicting patients' risks using AI. However, most existing risk prediction approache…
View article: KIT-LSTM: Knowledge-guided Time-aware LSTM for Continuous Clinical Risk Prediction
KIT-LSTM: Knowledge-guided Time-aware LSTM for Continuous Clinical Risk Prediction Open
Rapid accumulation of temporal Electronic Health Record (EHR) data and recent advances in deep learning have shown high potential in precisely and timely predicting patients’ risks using AI. However, most existing risk prediction approache…
View article: Prediction of Mortality and Major Adverse Kidney Events in Critically Ill Patients With Acute Kidney Injury
Prediction of Mortality and Major Adverse Kidney Events in Critically Ill Patients With Acute Kidney Injury Open
View article: Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement Therapy
Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement Therapy Open
Background and objectives Hypophosphatemia is commonly observed in patients receiving continuous KRT. Patients who develop hypophosphatemia may be at risk of respiratory and neuromuscular dysfunction and therefore subject to prolongation o…
View article: Bone Quality and Fractures in Women With Osteoporosis Treated With Bisphosphonates for 1 to 14 Years
Bone Quality and Fractures in Women With Osteoporosis Treated With Bisphosphonates for 1 to 14 Years Open
Oral bisphosphonates are the primary medication for osteoporosis, but concerns exist regarding potential bone‐quality changes or low‐energy fractures. This cross‐sectional study used artificial intelligence methods to analyze relationships…
View article: Characteristics and Outcomes of Survivors of Critical Illness and Acute Kidney Injury Followed in a Pilot Acute Kidney Injury Clinic
Characteristics and Outcomes of Survivors of Critical Illness and Acute Kidney Injury Followed in a Pilot Acute Kidney Injury Clinic Open
Surviving critical illness and acute kidney injury (AKI) carries a burden of morbidity and mortality that may be affected by post-discharge care. However, only 5% to 10% of AKI survivors receive nephrology post-discharge care, despite obse…
View article: Kidney Recovery in Patients With Acute Kidney Injury Treated in Outpatient Hemodialysis or Rehabilitation Facilities
Kidney Recovery in Patients With Acute Kidney Injury Treated in Outpatient Hemodialysis or Rehabilitation Facilities Open
View article: KGDAL
KGDAL Open
With the rapid accumulation of electronic health record (EHR) data, deep learning (DL) models have exhibited promising performance on patient risk prediction. Recent advances have also demonstrated the effectiveness of knowledge graphs (KG…
View article: Author response for "Bone Quality and Fractures in Women with Osteoporosis Treated with Bisphosphonates for One to Fourteen Years"
Author response for "Bone Quality and Fractures in Women with Osteoporosis Treated with Bisphosphonates for One to Fourteen Years" Open
View article: ELMV: an Ensemble-Learning Approach for Analyzing Electrical Health Records with Significant Missing Values
ELMV: an Ensemble-Learning Approach for Analyzing Electrical Health Records with Significant Missing Values Open
Many real-world Electronic Health Record (EHR) data contains a large proportion of missing values. Leaving substantial portion of missing information unaddressed usually causes significant bias, which leads to invalid conclusion to be draw…