Lucas Lindeboom
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View article: Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T Open
NADH and NAD+ act as electron donors and acceptors and NAD+ was shown to stimulate mitochondrial biogenesis and metabolic health. We here develop a non-invasive Phosphorous Magnetic Resonance Spectroscopy (31
View article: Home monitoring of patients with chronic kidney disease
Home monitoring of patients with chronic kidney disease Open
View article: #2118 Monitoring hemodynamics in dialysis: on the feasibility of semi-continuous and multifrequency thoracic bioimpedance measurements by a wearable device
#2118 Monitoring hemodynamics in dialysis: on the feasibility of semi-continuous and multifrequency thoracic bioimpedance measurements by a wearable device Open
Background and Aims Hemodialysis patients face a high hemodynamic variability in blood pressure and fluid status, which contributes to their cardiovascular mortality. Currently, intradialytic hemodynamic monitoring has to rely on cuff-base…
View article: The Feasibility of Semi-Continuous and Multi-Frequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients
The Feasibility of Semi-Continuous and Multi-Frequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients Open
Repeated single-point measurements of thoracic bioimpedance at a single (low) frequency are strongly related to fluid changes during hemodialysis. Extension to semi-continuous measurements may provide longitudinal details in the time patte…
View article: The Feasibility of Semi-continuous and Multifrequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients
The Feasibility of Semi-continuous and Multifrequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients Open
Repeated single-point measurements of thoracic bioimpedance at single (low)-frequency are strongly related to fluid changes during hemodialysis. Extension to semi-continuous measurements may provide longitudinal details in the time pattern…
View article: Comparison of whole body versus thoracic bioimpedance in relation to ultrafiltration volume and systolic blood pressure during hemodialysis
Comparison of whole body versus thoracic bioimpedance in relation to ultrafiltration volume and systolic blood pressure during hemodialysis Open
We examined the role of whole body and thoracic bioimpedance in hemodynamic changes during hemodialysis. Whole body and thoracic bioimpedance signals were strongly related to ultrafiltration volume and moderately, negatively, to changes in…
View article: #3651 COMPARISON OF WHOLE-BODY VERSUS THORACIC BIOIMPEDANCE IN RELATION TO ULTRAFILTRATION VOLUME AND SYSTOLIC BLOOD PRESSURE DURING HEMODIALYSIS
#3651 COMPARISON OF WHOLE-BODY VERSUS THORACIC BIOIMPEDANCE IN RELATION TO ULTRAFILTRATION VOLUME AND SYSTOLIC BLOOD PRESSURE DURING HEMODIALYSIS Open
Background and Aims In contrast to portable whole-body bioimpedance, which estimates fluid status at a single point in time, thoracic bioimpedance applied by a wearable device could enable continuous measurements. However, clinical experie…
View article: PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans
PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans Open
View article: A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial
A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial Open
Objective Increasing overnight fasting time seems a promising strategy to improve metabolic health in individuals with nonalcoholic fatty liver (NAFL). Mechanisms underlying the beneficial effects of fasting may be related to larger fluctu…
View article: Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions
Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions Open
Background: Current guidelines aim to limit the dietary glycemic index (GI) and intake of saturated fatty acids (SFA). Several studies have shown favorable effects of low-GI or low-SFA diets on intrahepatic lipid content (IHL), but these s…
View article: Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans
Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans Open
BACKGROUNDAt the onset of exercise, the speed at which phosphocreatine (PCr) decreases toward a new steady state (PCr on-kinetics) reflects the readiness to activate mitochondrial ATP synthesis, which is secondary to Acetyl-CoA availabilit…
View article: An Implantable Neuromorphic Sensing System Featuring Near-Sensor Computation and Send-on-Delta Transmission for Wireless Neural Sensing of Peripheral Nerves
An Implantable Neuromorphic Sensing System Featuring Near-Sensor Computation and Send-on-Delta Transmission for Wireless Neural Sensing of Peripheral Nerves Open
This paper presents a bio-inspired event-driven neuromorphic sensing system (NSS) capable of performing on-chip feature extraction and "send-on-delta" pulse-based transmission, targeting peripheral-nerve neural recording applications. The …
View article: PCr/ATP Ratios and Mitochondrial Function in The Heart. A Comparative Study in Humans.
PCr/ATP Ratios and Mitochondrial Function in The Heart. A Comparative Study in Humans. Open
Objectives The objective of the study was to validate PCr/ATP ratios as an in vivo marker for cardiac mitochondrial function.Background Cardiac energy status, measured as PCr/ATP ratio with 31P-MRS in vivo, was shown to be a pro…
View article: On the potential of wearable bioimpedance for longitudinal fluid monitoring in end-stage kidney disease
On the potential of wearable bioimpedance for longitudinal fluid monitoring in end-stage kidney disease Open
Bioimpedance spectroscopy (BIS) has proven to be a promising non-invasive technique for fluid monitoring in haemodialysis (HD) patients. While current BIS-based monitoring of pre- and post-dialysis fluid status utilizes benchtop devices, d…
View article: L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility
L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility Open
Acute L-carnitine infusion could not alleviated lipid-induced insulin resistance and metabolic inflexibility and did not alter skeletal muscle carnitine availability. Possibly, lipid-induced insulin resistance may also have affected carnit…
View article: Application of a BIlinear Rotation Decoupling (BIRD) filter in combination with J‐difference editing for indirect <sup>13</sup>C measurements in the human liver
Application of a BIlinear Rotation Decoupling (BIRD) filter in combination with J‐difference editing for indirect <sup>13</sup>C measurements in the human liver Open
Purpose Recently, we introduced a quantum coherence based method (ge‐HSQC) for indirect 13 C‐MRS in the liver to track 13 C‐labeled lipids into the hepatic lipid pool in vivo. This approach is more robust in case of respiratory motion, how…
View article: Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance Open
View article: Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans
Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans Open
View article: Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations Open
1 H‐MR spectroscopy of skeletal muscle provides insight into metabolism that is not available noninvasively by other methods. The recommendations given in this article are intended to guide those who have basic experience in general MRS to…
View article: Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial
Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial Open
View article: Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content
Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content Open
Context There is an ongoing debate about whether and how fructose is involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). A recent experimental study showed an increased intrahepatic triglyceride (IHTG) content in mice…
View article: Contribution of Liver Fat to Weight Loss–Induced Changes in Serum Hepatokines: A Randomized Controlled Trial
Contribution of Liver Fat to Weight Loss–Induced Changes in Serum Hepatokines: A Randomized Controlled Trial Open
Dietary weight loss has differential effects on hepatokines. This study shows that the change in serum IGF1 levels after dietary weight loss is mediated by the change in IHTG content.
View article: Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups
Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups Open
In recent years, several microRNAs (miRNAs)-post-transcriptional regulators of gene expression-have been linked to the regulation of peripheral insulin sensitivity. Many of these studies, however, have been conducted in cell or animal mode…
View article: Independent tissue contributors to obesity-associated insulin resistance
Independent tissue contributors to obesity-associated insulin resistance Open
Funding was from the Top Institute Food and Nutrition.
View article: Measurement of lipid composition in human skeletal muscle and adipose tissue with <sup>1</sup>H‐MRS homonuclear spectral editing
Measurement of lipid composition in human skeletal muscle and adipose tissue with <sup>1</sup>H‐MRS homonuclear spectral editing Open
Purpose Accumulation of triglycerides in nonadipose tissue (e.g. ectopic lipids) is characteristic of metabolic derangements and is linked to insulin resistance and cardiovascular disease. Although the detrimental effects of the total amou…
View article: Quantum coherence spectroscopy to measure dietary fat retention in the liver
Quantum coherence spectroscopy to measure dietary fat retention in the liver Open
The prevalence of fatty liver reaches alarming proportions. Fatty liver increases the risk for insulin resistance, cardiovascular disease, and nonalcoholic steatohepatitis (NASH). Although extensively studied in a preclinical setting, the …
View article: Longitudinal relaxation time editing for acetylcarnitine detection with <sup>1</sup>H‐MRS
Longitudinal relaxation time editing for acetylcarnitine detection with <sup>1</sup>H‐MRS Open
Purpose Acetylcarnitine formation is suggested to be crucial in sustaining metabolic flexibility and glucose homeostasis. Recently, we introduced a method to detect acetylcarnitine in vivo with long TE 1 H‐MRS. Differences in T 1 relaxatio…
View article: Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise
Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise Open