Marian Regan
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View article: Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil
Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil Open
View article: Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis
Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis Open
Objective To investigate the association between socioeconomic deprivation and outcomes following TNF inhibitor (TNFi) treatment. Methods Individuals commencing their first TNFi in the British Society for Rheumatology Biologics Register fo…
View article: Non-trough adalimumab and certolizumab drug levels associated with a therapeutic EULAR response in adherent patients with rheumatoid arthritis
Non-trough adalimumab and certolizumab drug levels associated with a therapeutic EULAR response in adherent patients with rheumatoid arthritis Open
Objectives Interventions aimed at increasing TNF-α inhibitor serum drug levels (SDLs) may improve treatment response; however, previous studies suggesting SDL cut-offs have not accounted for treatment adherence. The aim of this study was t…
View article: EP28 A case of ANCA vasculitis presenting with Sjögren’s serology
EP28 A case of ANCA vasculitis presenting with Sjögren’s serology Open
Case report - Introduction Sjögren’s is an autoimmune multisystem disorder characterised by xerostomia, keratoconjunctivitis sicca and extra glandular manifestations. The presence of sicca symptoms helps with diagnosis but up to 20% patien…
View article: Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials
Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials Open
View article: Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome
Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome Open
Objectives To report on fatigue in patients from the United Kingdom primary Sjögren’s syndrome (pSS) registry identifying factors associated with fatigue and robust to assignable causes such as comorbidities and medications associated with…
View article: 1. SLE and Pregnancy
1. SLE and Pregnancy Open
View article: Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry
Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry Open
This is a correction to:
\nRheumatology, Volume 55, Issue 3, March 2016, Pages 544–552, https://doi.org/10.1093/rheumatology/kev373
View article: Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome
Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome Open
View article: Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy
Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy Open
Objective To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity. Methods Archive data from the UK Primary Sjög…
View article: Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines
Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines Open
Objectives This article reports relationships between serum cytokine levels and patient-reported levels of fatigue, in the chronic immunological condition primary Sjögren's syndrome (pSS). Methods Blood levels of 24 cytokines were measured…
View article: A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren’s Syndrome
A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren’s Syndrome Open
Systematic analysis of gene expression data from pSS patients discordant for fatigue identified 55 genes which are predictive of fatigue level using SVM classification. This list represents the first step in understanding the underlying pa…
View article: Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry
Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry Open
The UKPSSR identified a number of options for trial design, including selection on ESSDAI ⩾5, ESSPRI ⩾5 and serological and other parameters.
View article: 213. Eligibility for Clinical Trials in Primary Sjögren’s Syndrome: Lessons from the UK Primary Sjögren’s Registry
213. Eligibility for Clinical Trials in Primary Sjögren’s Syndrome: Lessons from the UK Primary Sjögren’s Registry Open
View article: Sjögren's syndrome and other connective tissue disorders
Sjögren's syndrome and other connective tissue disorders Open