Lucas Narciso
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View article: First-in-human PET neuroimaging of [18F]OXD-2314
First-in-human PET neuroimaging of [18F]OXD-2314 Open
View article: External delay and dispersion correction of automatically sampled arterial blood with dual flow rates
External delay and dispersion correction of automatically sampled arterial blood with dual flow rates Open
Objective . Arterial sampling for PET imaging often involves continuously measuring the radiotracer activity concentration in blood using an automatic blood sampling system (ABSS). We proposed and validated an external delay and dispersion…
View article: [18F]SynVest-1 PET imaging in people with Parkinson’s disease
[18F]SynVest-1 PET imaging in people with Parkinson’s disease Open
The [18F]SynVest-1 radiotracer targets the synaptic vesicle glycoprotein 2A (SV2A) and is a proxy of presynaptic density. Parkinson’s disease is associated with synaptic dysfunction. Here we investigated synaptic density via the [18F]SynVe…
View article: Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET
Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET Open
Background Quantification of the cerebral metabolic rate of glucose (CMRGlu) by dynamic [ 18 F]FDG PET requires invasive arterial sampling. Alternatives to using an arterial input function (AIF) include the simultaneous estimation (SIME) a…
View article: Aiming for [18F]FDG-PET acquisition time reduction in clinical practice for neurological patients
Aiming for [18F]FDG-PET acquisition time reduction in clinical practice for neurological patients Open
View article: Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [18F]FEPPA positron emission tomography
Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [18F]FEPPA positron emission tomography Open
View article: Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET
Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET Open
Background: Quantification of cerebral glucose metabolism by dynamic [ 18 F]FDG PET is often limited to the cerebral metabolic rate of glucose (CMRGlu) due to the challenges associated with obtaining microparameters at the voxelwise level …
View article: Concordance of regional hypoperfusion by pCASL MRI and 15O-water PET in frontotemporal dementia: Is pCASL an efficacious alternative?
Concordance of regional hypoperfusion by pCASL MRI and 15O-water PET in frontotemporal dementia: Is pCASL an efficacious alternative? Open
View article: Sensitivity of Arterial Spin Labeling for Characterization of Longitudinal Perfusion Changes in Frontotemporal Dementia and Related Disorders
Sensitivity of Arterial Spin Labeling for Characterization of Longitudinal Perfusion Changes in Frontotemporal Dementia and Related Disorders Open
With the appropriate labeling parameters, SD-pCASL is a promising approach for assessing longitudinal changes in CBF associated with FTD.
View article: Optimization of reconstruction parameters in [18F]FDG PET brain images aiming scan time reduction
Optimization of reconstruction parameters in [18F]FDG PET brain images aiming scan time reduction Open
Iterative image reconstruction methods are widely used in PET due to their better image quality when compared to analytical methods. However, inaccurate quantification occurs in low activity concentration regions, which leads to biased qua…
View article: A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model
A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model Open
The gold standard for imaging the cerebral metabolic rate of oxygen (CMRO2) is positron emission tomography (PET); however, it is an invasive and complex procedure that also requires correction for recirculating 15O-H…
View article: Semiquantification Study of [11C]-(R)-PK11195 PET Brain Images in Multiple Sclerosis
Semiquantification Study of [11C]-(R)-PK11195 PET Brain Images in Multiple Sclerosis Open
PET brain images with [11C]-(R)-PK11195 are being widely used to visualize microglial activation in vivo in neurodegenerative diseases, such as multiple sclerosis (MS). The aim of this study is to investigate the uptake behavior in juxtaco…