Lucas Patel
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View article: Personalised whole-body modelling links gut microbiota to metabolic perturbations in Alzheimer’s disease
Personalised whole-body modelling links gut microbiota to metabolic perturbations in Alzheimer’s disease Open
The human gut microbiome has been linked to metabolic disturbances in Alzheimer’s disease (AD). However, the mechanisms by which gut microbes might influence metabolic dysfunction in AD remain poorly understood. Previously, we used constra…
View article: Industrialization drives convergent microbial and physiological shifts in the human metaorganism
Industrialization drives convergent microbial and physiological shifts in the human metaorganism Open
Summary Understanding how host lifestyle and industrialization shape the human gut microbiome and intestinal physiology requires multimodal analyses across diverse global host contexts. Here, we generate multivariate data from the Global M…
View article: Versatile wastewater monitoring of pathogens and antimicrobial resistance enabled by metatranscriptomics and long-read metagenomics
Versatile wastewater monitoring of pathogens and antimicrobial resistance enabled by metatranscriptomics and long-read metagenomics Open
View article: Environmental and Maternal Imprints on Infant Gut Metabolic Programming
Environmental and Maternal Imprints on Infant Gut Metabolic Programming Open
Early life is a critical period for immune and metabolic programming, but developmental patterns remain underexplored in populations from low- and middle-income countries. Here, we profiled the microbiome and metabolome of 55 Bangladeshi m…
View article: The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns
The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns Open
Space habitation provides unique challenges in built environments isolated from Earth. We produced a 3D map of the microbes and metabolites throughout the United States Orbital Segment (USOS) of the International Space Station (ISS) with 8…
View article: ChIP provides 10-fold microbial DNA enrichment from tissue while minimizing bias
ChIP provides 10-fold microbial DNA enrichment from tissue while minimizing bias Open
View article: Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data
Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data Open
As next-generation sequencing technologies produce deeper genome coverages at lower costs, there is a critical need for reliable computational host DNA removal in metagenomic data. We find that insufficient host filtration using prior huma…
View article: Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data
Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data Open
As next-generation sequencing technologies produce deeper genome coverages at lower costs, there is a critical need for reliable computational host DNA removal in metagenomic data. We find that insufficient host filtration using prior huma…
View article: Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial
Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial Open
Background Evidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical trial to determine if intensive lifestyle changes may beneficially affect the progression of mild cognitive impa…
View article: Longitudinal analysis and treatment of neuropsychiatric symptoms in post-acute sequelae of COVID-19
Longitudinal analysis and treatment of neuropsychiatric symptoms in post-acute sequelae of COVID-19 Open
View article: Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity
Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity Open
View article: Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity
Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity Open
Bacteria possess an array of defenses against foreign invaders, including diverse nucleases that target and destroy the genome of an invading bacteriophage or foreign DNA element. A recently-described bacteriophage immunity pathway employs…