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View article: Avian and Human Turicibacter Isolates Possess Bile Salt Hydrolases with Activity Against Tauro-Conjugated Bile Acids
Avian and Human Turicibacter Isolates Possess Bile Salt Hydrolases with Activity Against Tauro-Conjugated Bile Acids Open
The genus Turicibacter is a common inhabitant of the small intestine of numerous animal species, including chickens. However, little is known about the phenotypic and genetic diversity of the genus. Within the chicken small intestine, bile…
View article: A Platform Approach for Designing Sustainable Indole Thiosemicarbazone Corrosion Inhibitors with Enhanced Adsorption Properties
A Platform Approach for Designing Sustainable Indole Thiosemicarbazone Corrosion Inhibitors with Enhanced Adsorption Properties Open
With an estimated global cost of $2.5 trillion per year, metal corrosion represents a major challenge across all industrial sectors. Numerous inorganic and organic corrosion inhibitors have been developed, but there are growing concerns ab…
View article: Shotgun metabolomic analysis of killer whale (Orcinus orca) exhaled breath condensate
Shotgun metabolomic analysis of killer whale (Orcinus orca) exhaled breath condensate Open
The ocean is facing many anthropogenic stressors caused from both pollution and climate change. These stressors are significantly impacting and changing the ocean’s ecosystem, and as such, methods must continually be developed that can imp…
View article: Dynamic relationships among pathways producing hydrocarbons and fatty acids of maize silk cuticular waxes
Dynamic relationships among pathways producing hydrocarbons and fatty acids of maize silk cuticular waxes Open
The hydrophobic cuticle is the first line of defense between aerial portions of plants and the external environment. On maize (Zea mays L.) silks, the cuticular cutin matrix is infused with cuticular waxes, consisting of a homologous serie…
View article: Endocannabinoid and psychological responses to acute resistance exercise in trained and untrained adults
Endocannabinoid and psychological responses to acute resistance exercise in trained and untrained adults Open
Introduction This study examined the effects of acute resistance exercise on circulating endocannabinoid (eCB) and mood responses in trained and untrained healthy adults. Methods Thirty-two healthy adults (22.1 ± 2.9 years) were recruited …
View article: The NADPH Oxidase Inhibitor, Mitoapocynin, Mitigates DFP-Induced Reactive Astrogliosis in a Rat Model of Organophosphate Neurotoxicity
The NADPH Oxidase Inhibitor, Mitoapocynin, Mitigates DFP-Induced Reactive Astrogliosis in a Rat Model of Organophosphate Neurotoxicity Open
NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/k…
View article: Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare
Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare Open
Saracatinib/AZD0530 (SAR), a Src tyrosine kinase inhibitor, mitigates seizure-induced brain pathology in epilepsy models upon repeated oral dosing. However, repeated dosing is stressful and can be challenging in some seizing animals. To ov…
View article: Endocannabinoid and psychological responses to acute resistance exercise in trained and untrained adults
Endocannabinoid and psychological responses to acute resistance exercise in trained and untrained adults Open
Objective This study examined the effects of acute resistance exercise on circulating endocannabinoid (eCB) and mood responses in trained and untrained healthy adults. Methods: Thirty-two healthy adults (22.1 ± 2.9 years) were recruited fr…
View article: Clostridioides difficile Infection Dysregulates Brain Dopamine Metabolism
Clostridioides difficile Infection Dysregulates Brain Dopamine Metabolism Open
The gut-brain axis is thought to play a significant role in the development and manifestation of neurologic diseases. This study reports significant alterations in the brain dopamine metabolism in mice infected with C. difficile , an impor…
View article: Maize Zmcyp710a8 Mutant as a Tool to Decipher the Function of Stigmasterol in Plant Metabolism
Maize Zmcyp710a8 Mutant as a Tool to Decipher the Function of Stigmasterol in Plant Metabolism Open
Sterols are integral components of membrane lipid bilayers in eukaryotic organisms and serve as precursors to steroid hormones in vertebrates and brassinosteroids (BR) in plants. In vertebrates, cholesterol is the terminal sterol serving b…
View article: <i>Clostridioides difficile</i>infection increases circulating p-cresol levels and dysregulates brain dopamine metabolism: linking gut-brain axis to autism spectrum disorders?
<i>Clostridioides difficile</i>infection increases circulating p-cresol levels and dysregulates brain dopamine metabolism: linking gut-brain axis to autism spectrum disorders? Open
Gastrointestinal illnesses are one of the most common comorbidities reported in patients with neurodevelopmental diseases, including autism spectrum disorders (ASD). Gut dysbiosis, overgrowth of C. difficile , and gut microbiota-associated…
View article: 289 Serum Trace Minerals in Late Gestation Sows at Variable Risk for Pelvic Organ Prolapse
289 Serum Trace Minerals in Late Gestation Sows at Variable Risk for Pelvic Organ Prolapse Open
Within the last decade, pelvic organ prolapse (POP) resulting in sow mortality has become an increasing concern for the U.S. swine industry, contributing approximately 21% of all sow deaths. While little is known regarding the etiology pre…
View article: <p>Particulate and solubilized &beta;-glucan and non-&beta;-glucan fractions of <em>Euglena gracilis</em> induce pro- and anti-inflammatory innate immune cell responses and exhibit antioxidant properties</p>
Particulate and solubilized β-glucan and non-β-glucan fractions of <em>Euglena gracilis</em> induce pro- and anti-inflammatory innate immune cell responses and exhibit antioxidant properties Open
The effects of EG on immune function are only partially attributable to the content of the β-glucan, paramylon. The regulation of additional cellular responses, such a reactive oxygen species production and resistance to oxidative stress, …
View article: Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats
Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats Open
Schirmer strips represent a good option for lacrimal doxycycline quantification, although the collection and subsequent extraction have to be optimized to improve drug recovery.